Impact of Maternal Pre-Pregnancy Underweight on Cord Blood Metabolome: An Analysis of the Population-Based Survey of Neonates in Pomerania (SNiP).

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Fetal Blood*/metabolism ; Fetal Blood*/chemistry ; Metabolome* ; Thinness*/blood ; Body Mass Index*; Humans ; Female ; Pregnancy ; Infant, Newborn ; Adult ; Fetal Growth Retardation/blood ; Male

Intrauterine growth restriction leads to an altered lipid and amino acid profile in the cord blood at the end of pregnancy. Pre-pregnancy underweight is an early risk factor for impaired fetal growth. The aim of this study was to investigate whether a pre-pregnancy body mass index (ppBMI) of <18.5 kg/m ² , as early as at the beginning of pregnancy, is associated with changes in the umbilical cord metabolome. In a sample of the Survey of Neonates in Pomerania (SNIP) birth cohort, the cord blood metabolome of n = 240 newborns of mothers with a ppBMI of <18.5 kg/m ² with n = 208 controls (ppBMI of 18.5-24.9 kg/m ² ) was measured by NMR spectrometry. A maternal ppBMI of <18.5 kg/m ² was associated with increased concentrations of HDL4 cholesterol, HDL4 phospholipids, VLDL5 cholesterol, HDL 2, and HDL4 Apo-A1, as well as decreased VLDL triglycerides and HDL2 free cholesterol. A ppBMI of <18.5 kg/m ² combined with poor intrauterine growth (a gestational weight gain (GWG) < 25th percentile) was associated with decreased concentrations of total cholesterol; cholesterol transporting lipoproteins (LDL4, LDL6, LDL free cholesterol, and HDL2 free cholesterol); LDL4 Apo-B; total Apo-A2; and HDL3 Apo-A2. In conclusion, maternal underweight at the beginning of pregnancy already results in metabolic changes in the lipid profile in the cord blood, but the pattern changes when poor GWG is followed by pre-pregnancy underweight.

Int J Epidemiol. 2019 Apr 1;48(2):433-444. (PMID: 30649331)
Am Heart J. 2016 Oct;180:54-63. (PMID: 27659883)
Sci Rep. 2016 Oct 07;6:34857. (PMID: 27713555)
Lancet. 1996 Nov 9;348(9037):1264-8. (PMID: 8909378)
BMJ. 1997 Oct 4;315(7112):837-40. (PMID: 9353502)
Eur J Obstet Gynecol Reprod Biol. 2003 Sep 22;110 Suppl 1:S50-4. (PMID: 12965090)
J Endocrinol. 2019 Jul 1;242(1):T135-T144. (PMID: 31207580)
Med Sci Monit. 2014 Oct 30;20:2097-105. (PMID: 25357084)
PLoS One. 2010 Nov 29;5(11):e14126. (PMID: 21124730)
PLoS One. 2012;7(6):e39324. (PMID: 22723995)
Obes Rev. 2014 Apr;15(4):338-47. (PMID: 24321007)
Metabolites. 2022 Sep 13;12(9):. (PMID: 36144264)
J Clin Endocrinol Metab. 2007 Feb;92(2):681-4. (PMID: 17148563)
Sci Rep. 2018 Sep 11;8(1):13614. (PMID: 30206284)
Eur Heart J. 2023 Nov 7;44(42):4408-4418. (PMID: 37632410)
N Engl J Med. 1998 Jan 15;338(3):147-52. (PMID: 9428815)
BMC Public Health. 2007 Jul 24;7:168. (PMID: 17650297)
Environ Epigenet. 2019 Apr 01;5(1):dvz004. (PMID: 30956810)
BMC Pregnancy Childbirth. 2024 Apr 22;24(1):297. (PMID: 38649888)
Int J Mol Sci. 2021 May 06;22(9):. (PMID: 34066314)
Clin Obstet Gynecol. 2006 Jun;49(2):236-56. (PMID: 16721104)
Am J Obstet Gynecol. 1990 Jan;162(1):253-61. (PMID: 2301500)
J Epidemiol Community Health. 1992 Feb;46(1):8-11. (PMID: 1573367)
Eur Heart J. 2021 Dec 14;42(47):4791-4806. (PMID: 34472586)
Lancet. 2008 Jan 19;371(9608):243-60. (PMID: 18207566)
Arch Gynecol Obstet. 2007 Jan;275(1):39-43. (PMID: 16967276)
Amino Acids. 2022 Jul;54(7):977-988. (PMID: 35353249)
Paediatr Perinat Epidemiol. 2007 Nov;21(6):518-24. (PMID: 17937737)
Paediatr Perinat Epidemiol. 2020 Mar;34(2):204-213. (PMID: 32003026)
J Pediatr Endocrinol Metab. 2020 Jul 28;33(7):821-833. (PMID: 32568734)
Nutrition. 2022 Nov-Dec;103-104:111762. (PMID: 35843039)
Am J Clin Nutr. 2011 Dec;94(6 Suppl):1799S-1802S. (PMID: 21613556)
Int J Gynaecol Obstet. 2006 Dec;95(3):242-7. (PMID: 17007857)
Diabetes Care. 2017 Jul;40(7):902-910. (PMID: 28637888)
Indian J Med Res. 2016 Aug;144(2):194-199. (PMID: 27934797)
Paediatr Perinat Epidemiol. 2010 Mar;24(2):190-9. (PMID: 20415776)
Biomedicines. 2021 Mar 30;9(4):. (PMID: 33808220)
Acta Paediatr. 2021 May;110(5):1452-1460. (PMID: 33283311)
PLoS Med. 2019 Feb 11;16(2):e1002744. (PMID: 30742624)
Biol Neonate. 1991;60(3-4):187-92. (PMID: 1797121)
J Perinat Med. 2012 Jan 06;40(3):287-96. (PMID: 22505508)
Indian J Clin Biochem. 2013 Apr;28(2):152-7. (PMID: 24426201)
Int J Mol Sci. 2014 Sep 12;15(9):16153-85. (PMID: 25222554)
BMC Med. 2022 Jul 25;20(1):242. (PMID: 35871677)
Arch Gynecol Obstet. 2012 Oct;286(4):905-11. (PMID: 22695822)
JAMA. 2017 Jun 06;317(21):2207-2225. (PMID: 28586887)
N Engl J Med. 2005 Oct 27;353(17):1802-9. (PMID: 16251536)
BMJ. 1990 Aug 4;301(6746):259-62. (PMID: 2390618)
Physiol Genomics. 2011 Nov 21;43(22):1255-62. (PMID: 21954452)
Am J Epidemiol. 2009 Sep 1;170(5):622-31. (PMID: 19638481)
Am J Phys Anthropol. 2013 Dec;152 Suppl 57:79-93. (PMID: 24249592)
Curr Diab Rep. 2018 Aug 15;18(10):76. (PMID: 30112615)
Int J Obes (Lond). 2006 Dec;30 Suppl 4:S18-22. (PMID: 17133231)
Z Geburtshilfe Neonatol. 2014 Oct;218(5):210-7. (PMID: 25353215)
Nutrients. 2021 Nov 22;13(11):. (PMID: 34836431)
Metabolism. 1983 Sep;32(9):919-23. (PMID: 6888272)
Physiol Rev. 2016 Oct;96(4):1509-65. (PMID: 27604528)
BMC Pregnancy Childbirth. 2015 Feb 05;15:21. (PMID: 25652811)
J Pharm Biomed Anal. 2021 Nov 30;206:114381. (PMID: 34583124)
J Matern Fetal Neonatal Med. 2012 Oct;25(Suppl 5):13-8. (PMID: 23025763)
J Clin Endocrinol Metab. 2016 Mar;101(3):871-9. (PMID: 26709969)
Adv Clin Exp Med. 2019 Sep;28(9):1263-1269. (PMID: 31430068)
JAMA. 2019 May 7;321(17):1702-1715. (PMID: 31063572)
Metabolites. 2019 Nov 06;9(11):. (PMID: 31698738)
Placenta. 2002 Apr;23 Suppl A:S20-7. (PMID: 11978056)
J Dev Orig Health Dis. 2016 Dec;7(6):672-677. (PMID: 27572697)
Circ Res. 2020 May 22;126(11):1613-1627. (PMID: 32437301)
Analyst. 2014 Mar 7;139(5):1168-77. (PMID: 24443722)
Obes Facts. 2012;5(5):660-70. (PMID: 23108202)

n.a. Community Medicine Steering Committee of the University Medicine Greifswald

Keywords: amino acids; gestational weight gain; lipoprotein; metabolome; neonatal outcome; placental ratio; pre-pregnancy BMI

Date Created: 20240727 Date Completed: 20240727 Latest Revision: 20240729

20250114

PMC11276627

10.3390/ijms25147552

39062795