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The Investigation of Kisspeptin, Spexin and Galanin in Euthyroid Women with Hashimoto's Thyroiditis.

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  • المؤلفون: Can U;Can U; Akdu S; Akdu S; Aktan AH; Aktan AH
  • المصدر:
    Endocrine research [Endocr Res] 2025 Feb; Vol. 50 (1), pp. 36-42. Date of Electronic Publication: 2024 Jul 26.
  • نوع النشر :
    Journal Article
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 8408548 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-4206 (Electronic) Linking ISSN: 07435800 NLM ISO Abbreviation: Endocr Res Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: New York, N.Y. : Dekker, c1984-
    • الموضوع:
      Galanin*/blood ; Hashimoto Disease*/blood ; Kisspeptins*/blood ; Peptide Hormones*/blood; Humans ; Female ; Adult ; Middle Aged ; Autoantibodies/blood
    • نبذة مختصرة :
      Objective: The hallmarks of Hashimoto's thyroiditis (HT) include the destruction of thyroid cells by leading to insulin resistance (IR), hypothyroidism, and metabolic abnormalities. Kisspeptin, spexin, and galanin control appetite and body weight (BW) to regulate metabolisms. Here, we sought to determine if galanin, kisspeptin, and spexin are linked to the pathophysiology of HT in euthyroid female individuals.
      Methods: Forty-five women with HT and 45 healthy control women of the same age participated in the current study. The enzyme-linked immunosorbent assay (ELISA) method was used to measure the serum levels of galanin, spexin, and kisspeptin.
      Results: In comparison to the controls, HT patients had significantly higher levels of kisspeptin ( p  < 0.01), galanin ( p  < 0.01), anti-thyroid peroxidase (anti-TPO) ( p  < 0.001), anti-thyroglobulin (anti-Tg) ( p  < 0.001), and body mass index (BMI) ( p  < 0.05). The two groups were comparable in terms of spexin, free triiodothyronine-3 (fT3), fT4, thyroid-stimulating hormone (TSH) levels, and homeostatic model assessment for insulin resistance (HOMA-IR). Galanin and kisspeptin were seen to have a positive correlation ( p  < 0.01; r  = 0.786).
      Conclusions: Euthyroid women with HT were found to have higher levels of kisspeptin and galanin. These results imply that kisspeptin and galanin may be linked to the pathogenesis of hypothyroidism, and as a result, we believe that these markers may be beneficial in the early detection and treatment of HT patients.
    • Contributed Indexing:
      Keywords: Galanin; Hashimoto’s thyroiditis; kisspeptin; spexin
    • الرقم المعرف:
      88813-36-9 (Galanin)
      0 (SPX protein, human)
      0 (Kisspeptins)
      0 (Peptide Hormones)
      0 (KISS1 protein, human)
      0 (Autoantibodies)
      0 (anti-thyroglobulin)
    • الموضوع:
      Date Created: 20240726 Date Completed: 20250129 Latest Revision: 20250129
    • الموضوع:
      20250129
    • الرقم المعرف:
      10.1080/07435800.2024.2384576
    • الرقم المعرف:
      39056111