Cerebral perfusion metrics calculated directly from a hypoxia-induced step change in deoxyhemoglobin.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Cerebrovascular Circulation* ; Magnetic Resonance Imaging*/methods ; Hemoglobins*/metabolism ; Hypoxia*/metabolism; Humans ; Male ; Adult ; Female ; Contrast Media ; Brain/metabolism ; Brain/diagnostic imaging ; Brain/blood supply ; Young Adult ; Cerebral Blood Volume

Resting cerebral perfusion metrics can be calculated from the MRI ΔR 2 * signal during the first passage of an intravascular bolus of a Gadolinium-based contrast agent (GBCA), or more recently, a transient hypoxia-induced change in the concentration of deoxyhemoglobin ([dOHb]). Conventional analysis follows a proxy process that includes deconvolution of an arterial input function (AIF) in a tracer kinetic model. We hypothesized that the step reduction in magnetic susceptibility accompanying a step decrease in [dOHb] that occurs when a single breath of oxygen terminates a brief episode of lung hypoxia permits direct calculation of relative perfusion metrics. The time course of the ΔR 2 * signal response enables both the discrimination of blood arrival times and the time course of voxel filling. We calculated the perfusion metrics implied by this step signal change in seven healthy volunteers and compared them to those from conventional analyses of GBCA and dOHb using their AIF and indicator dilution theory. Voxel-wise maps of relative cerebral blood flow and relative cerebral blood volume had a high spatial and magnitude congruence for all three analyses (r > 0.9) and were similar in appearance to published maps. The mean (SD) transit times (s) in grey and white matter respectively for the step response (7.4 (1.1), 8.05 (1.71)) were greater than those for GBCA (2.6 (0.45), 3.54 (0.83)) attributable to the nature of their respective calculation models. In conclusion we believe these calculations of perfusion metrics derived directly from ΔR 2 * have superior merit to calculations via AIF by virtue of being calculated from a direct signal rather than through a proxy model which encompasses errors inherent in designating an AIF and performing deconvolution calculations.
(© 2024. The Author(s).)

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Keywords: Cerebral blood flow; Cerebral blood volume; Cerebrovascular; Deoxyhemoglobin; Hypoxia; Magnetic resonance imaging; Mean transit time

9008-02-0 (deoxyhemoglobin)
0 (Hemoglobins)
0 (Contrast Media)

Date Created: 20240725 Date Completed: 20240725 Latest Revision: 20240806

20240806

PMC11272773

10.1038/s41598-024-68047-w

39054379