Spontaneous vascular dysfunction in Dahl salt-sensitive male rats raised without a high-salt diet.

Publisher: published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society Country of Publication: United States NLM ID: 101607800 Publication Model: Print Cited Medium: Internet ISSN: 2051-817X (Electronic) Linking ISSN: 2051817X NLM ISO Abbreviation: Physiol Rep Subsets: MEDLINE

Original Publication: [Malden MA] : published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society, 2013-

Rats, Inbred Dahl* ; Hypertension*/physiopathology ; Hypertension*/etiology ; Rats, Inbred SHR* ; Sodium Chloride, Dietary*/adverse effects ; Mesenteric Arteries*/physiopathology ; Mesenteric Arteries*/drug effects ; Mesenteric Arteries*/metabolism; Animals ; Male ; Rats ; Endothelium, Vascular/physiopathology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Blood Pressure/physiology ; Vasodilation/drug effects ; Vasodilation/physiology ; Diet, Sodium-Restricted

Dahl salt-sensitive (SS) rats fed a high-salt diet, but not low-salt, exhibit vascular dysfunction. Several substrains of SS rats exist that differ in their blood pressure phenotypes and salt sensitivity. The goal of this study was to investigate whether the John-Rapp-derived SS rat (SS/Jr), which exhibits spontaneous hypertension on a low-salt diet, presents with hallmarks of vascular dysfunction observed in another experimental model of hypertension independent of dietary salt, the spontaneously hypertensive rat (SHR). Endothelium-intact aortic rings and mesenteric resistance arteries were isolated from low-salt fed adult male SS/Jr rats and SHRs, or their respective controls, for isometric wire myography. Vessels were challenged with cumulative concentrations of various vasoactive substances, in the absence or presence of nitric oxide synthase or cyclooxygenase inhibitors. Despite showing some differences in their responses to various vasoactive substances, both SS/Jr rats and SHRs exhibited key features of vascular dysfunction, including endothelial dysfunction and hyperresponsiveness to vasocontractile agonists. In conclusion, this study provides evidence to support the utility of the SS/Jr rat strain maintained on a low-salt diet as a valid experimental model for vascular dysfunction, a key feature of human hypertension.
(© 2024 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)

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R00 HL153896 United States HL NHLBI NIH HHS; R01 HL152162 United States HL NHLBI NIH HHS

Keywords: animal models of hypertension; endothelial dysfunction; salt‐sensitive hypertension; vascular dysfunction; vascular smooth muscle

0 (Sodium Chloride, Dietary)

Date Created: 20240724 Date Completed: 20240725 Latest Revision: 20240728

20250114

PMC11268988

10.14814/phy2.16165

39048525