Evolution of ion channels in cetaceans: a natural experiment in the tree of life.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Cetacea*/genetics ; Cetacea*/physiology ; Ion Channels*/genetics ; Ion Channels*/metabolism ; Evolution, Molecular*; Animals ; Phylogeny ; Computational Biology/methods ; Genome

Cetaceans represent a natural experiment within the tree of life in which a lineage changed from terrestrial to aquatic habitats. This shift involved phenotypic modifications, representing an opportunity to explore the genetic bases of phenotypic diversity. Among the different molecular systems that maintain cellular homeostasis, ion channels are crucial for the proper physiological functioning of all living species. This study aims to explore the evolution of ion channels during the evolutionary history of cetaceans. To do so, we created a bioinformatic pipeline to annotate the repertoire of ion channels in the genome of the species included in our sampling. Our main results show that cetaceans have, on average, fewer protein-coding genes and a higher percentage of annotated ion channels than non-cetacean mammals. Signals of positive selection were detected in ion channels related to the heart, locomotion, visual and neurological phenotypes. Interestingly, we predict that the NaV1.5 ion channel of most toothed whales (odontocetes) is sensitive to tetrodotoxin, similar to NaV1.7, given the presence of tyrosine instead of cysteine, in a specific position of the ion channel. Finally, the gene turnover rate of the cetacean crown group is more than three times faster than that of non-cetacean mammals.
(© 2024. The Author(s).)

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Code 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 2015/18269-1 Fundação Amazônia Paraense de Amparo à Pesquisa; 1210471 Fondo Nacional de Desarrollo Científico y Tecnológico; 1211481 Fondo Nacional de Desarrollo Científico y Tecnológico; 1231357 Fondo Nacional de Desarrollo Científico y Tecnológico; EQM160063 FONDEQUIP; NCN19_168 Millennium Scientific Initiative

Keywords: Gene turnover; NaV1.5; PKD1L1; SCN5A; TTX; Tetrodotoxin

0 (Ion Channels)

Date Created: 20240723 Date Completed: 20240723 Latest Revision: 20240805

20240806

PMC11266680

10.1038/s41598-024-66082-1

39043711