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Exploring functional and structural connectivity disruptions in spinocerebellar ataxia type 3: Insights from gradient analysis.
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- معلومة اضافية
- المصدر:
Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101473265 Publication Model: Print Cited Medium: Internet ISSN: 1755-5949 (Electronic) Linking ISSN: 17555930 NLM ISO Abbreviation: CNS Neurosci Ther Subsets: MEDLINE
- بيانات النشر:
Original Publication: Oxford, UK : Wiley-Blackwell, c2008-
- الموضوع:
- نبذة مختصرة :
Aims: Spinocerebellar Ataxia Type 3 (SCA3) is a rare genetic ataxia that impacts the entire brain and is characterized as a neurodegenerative disorder affecting the neural network. This study explores how alterations in the functional hierarchy, connectivity, and structural changes within specific brain regions significantly contribute to the heterogeneity of symptom manifestations in patients with SCA3.
Methods: We prospectively recruited 51 patients with SCA3 and 59 age-and sex-matched healthy controls. All participants underwent comprehensive multimodal neuroimaging and clinical assessments. In SCA3 patients, an innovative approach utilizing gradients in resting-state functional connectivity (FC) was employed to examine atypical patterns of hierarchical processing topology from sensorimotor to supramodal regions in the cerebellum and cerebrum. Coupling analyses of abnormal FC and structural connectivity among regions of interest (ROIs) in the brain were also performed to characterize connectivity alterations. Additionally, relationships between quantitative ROI values and clinical variables were explored.
Results: Patients with SCA3 exhibited either compression or expansion within the primary sensorimotor-to-supramodal gradient through four distinct calculation methods, along with disruptions in FC and structural connectivity coupling. A comprehensive correlation was identified between the altered gradients and the clinical manifestations observed in patients. Notably, altered fractional anisotropy values were not significantly correlated with clinical variables.
Conclusion: Abnormal gradients and connectivity in the cerebellar and cerebral cortices in SCA3 patients may contribute to disrupted motor-to-supramodal functions. Moreover, these findings support the potential utility of FCG analysis as a biomarker for diagnosing SCA3 and assessing treatment efficacy.
(© 2024 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.)
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- Grant Information:
81601478 National Natural Science Foundation of China; 82071910 National Natural Science Foundation of China; 414Z395 Senior Medical Talents Program of Chongqing for Young and Middle-aged; Young and Middle-aged Senior Medical Talents Studio of Chongqing; 2024YQBJ-2 Excellent Young Talent Fund of the First Affiliated Hospital of the Army Medical University
- Contributed Indexing:
Keywords: coupling; functional connectivity; gradient; spinocerebellar ataxia type 3; structural connectivity
- الموضوع:
Date Created: 20240716 Date Completed: 20240717 Latest Revision: 20240719
- الموضوع:
20240719
- الرقم المعرف:
PMC11251871
- الرقم المعرف:
10.1111/cns.14842
- الرقم المعرف:
39014518
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