Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Attenuated Salmonella typhimurium L forms suppress tumor growth and promote apoptosis in murine ovarian tumors.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
    • نبذة مختصرة :
      To study the effects of attenuated Salmonella typhimurium L forms on the in vivo tumorigenicity and apoptosis of murine epithelial ovarian cancer cells, as well as the related mechanisms. Attenuated Salmonella typhimurium VNP20009 was induced into bacterial L forms by using antibiotic ceftriaxone. CCK-8 cell proliferation assay showed that attenuated S. typhimurium L forms can inhibit the proliferation of murine ovarian epithelial cancer ID8 cells. Attenuated ST L forms can induce apoptosis and inhibit invasion ability of epithelial ovarian cancer cells in vitro. TUNEL assay showed that attenuated ST L forms can induce apoptosis of ID8 cells in murine ovarian tumors. Meanwhile, attenuated ST L forms inhibit tumor growth in murine ovarian tumors. The tumorigenicity-related proteins of xenograft tumors detected by immunohistochemistry and fluorescence quantitative RT-PCR assays showed that attenuated ST L forms can reduce the expression of proteins that promote tumor growth and metastasis, such as Lgals9 and MMP9. This study confirmed that attenuated ST L forms can suppress tumor growth and promote apoptosis in murine ovarian tumors. Attenuated ST L forms may serve as a novel biological agent for bacterial-mediated tumor therapy in epithelial ovarian cancer.
      (© 2024. The Author(s).)
    • References:
      PNAS Nexus. 2024 Jan 02;3(1):pgad484. (PMID: 38213616)
      Cancers (Basel). 2023 May 30;15(11):. (PMID: 37296952)
      Appl Microbiol Biotechnol. 2020 Apr;104(8):3517-3528. (PMID: 32095863)
      Cells. 2019 Jun 16;8(6):. (PMID: 31208120)
      Gut Microbes. 2016;7(2):171-7. (PMID: 26939530)
      Adv Drug Deliv Rev. 2022 Jun;185:114295. (PMID: 35429576)
      Int J Cancer. 2023 Sep 15;153(6):1257-1272. (PMID: 37323038)
      Signal Transduct Target Ther. 2024 Jan 10;9(1):14. (PMID: 38195682)
      Oncotarget. 2015 May 10;6(13):11369-77. (PMID: 25957417)
      Cureus. 2023 Nov 27;15(11):e49521. (PMID: 38156135)
      In Vivo. 2021 Nov-Dec;35(6):3067-3071. (PMID: 34697138)
      PLoS Biol. 2023 Aug 31;21(8):e3002253. (PMID: 37651408)
      Acta Biochim Biophys Sin (Shanghai). 2023 Feb 25;55(3):331-342. (PMID: 36786073)
      Philos Trans R Soc Lond B Biol Sci. 2016 Nov 5;371(1707):. (PMID: 27672147)
      Genes Dis. 2022 Jun 04;10(6):2366-2382. (PMID: 37554219)
      Signal Transduct Target Ther. 2023 May 8;8(1):182. (PMID: 37150786)
      Nat Cancer. 2023 Sep;4(9):1239-1257. (PMID: 37653142)
      BMC Cancer. 2023 Jun 20;23(1):569. (PMID: 37340370)
      J Ovarian Res. 2023 Jun 15;16(1):114. (PMID: 37322531)
      N Engl J Med. 2023 Dec 7;389(23):2162-2174. (PMID: 38055253)
      J Appl Microbiol. 2020 Jan;128(1):2-14. (PMID: 31038778)
      Proc Natl Acad Sci U S A. 2022 Jun 14;119(24):e2202719119. (PMID: 35675425)
      Eur J Immunol. 2021 Dec;51(12):3228-3238. (PMID: 34633664)
      J Immunother. 2020 Sep;43(7):217-221. (PMID: 32554977)
      Hematology. 2024 Dec;29(1):2288481. (PMID: 38108336)
      Appl Microbiol Biotechnol. 2024 Feb 19;108(1):218. (PMID: 38372808)
      Sci Rep. 2023 Apr 28;13(1):6982. (PMID: 37117633)
      J Cell Biochem. 2014 Nov;115(11):1996-2003. (PMID: 24924355)
      Cancer Res. 2023 Apr 14;83(8):1299-1314. (PMID: 36652557)
      Front Microbiol. 2023 Apr 04;14:1097413. (PMID: 37082179)
      Science. 2022 Nov 25;378(6622):858-864. (PMID: 36423303)
    • Grant Information:
      KJ2021ZD0076 the Key Fund Project of Anhui University Natural Science Research; S202210367026 Anhui Province Undergraduate Training Programs for Innovation and Entrepreneurship
    • Contributed Indexing:
      Keywords: ST; Salmonella typhimurium; Apoptosis; Epithelial ovarian cancer; L forms; Tumorigenicity
    • الرقم المعرف:
      0 (VNP 20009)
      EC 3.4.24.35 (Matrix Metalloproteinase 9)
      0 (Bacterial Vaccines)
    • الموضوع:
      Date Created: 20240711 Date Completed: 20240711 Latest Revision: 20240731
    • الموضوع:
      20240731
    • الرقم المعرف:
      PMC11239651
    • الرقم المعرف:
      10.1038/s41598-024-66898-x
    • الرقم المعرف:
      38992056