Quantified planar collagen distribution in healthy and degenerative mitral valve: biomechanical and clinical implications.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Mitral Valve*/metabolism ; Mitral Valve*/pathology ; Collagen*/metabolism; Humans ; Male ; Female ; Middle Aged ; Biomechanical Phenomena ; Aged ; Mitral Valve Prolapse/metabolism ; Mitral Valve Prolapse/pathology ; Adult

Degenerative mitral valve disease is a common valvular disease with two arguably distinct phenotypes: fibroelastic deficiency and Barlow's disease. These phenotypes significantly alter the microstructures of the leaflets, particularly the collagen fibers, which are the main mechanical load carriers. The predominant method of investigation is histological sections. However, the sections are cut transmurally and provide a lateral view of the microstructure of the leaflet, while the mechanics and function are determined by the planar arrangement of the collagen fibers. This study, for the first time, quantitatively examined planar collagen distribution quantitatively in health and disease using second harmonic generation microscopy throughout the thickness of the mitral valve leaflets. Twenty diseased samples from eighteen patients and six control samples were included in this study. Healthy tissue had highly aligned collagen fibers. In fibroelastic deficiency they are less aligned and in Barlow's disease they are completely dispersed. In both diseases, collagen fibers have two preferred orientations, which, in contrast to the almost constant one orientation in healthy tissues, also vary across the thickness. The results indicate altered in vivo mechanical stresses and strains on the mitral valve leaflets as a result of disease-related collagen remodeling, which in turn triggers further remodeling.
(© 2024. The Author(s).)

Circ Cardiovasc Imaging. 2015 May;8(5):. (PMID: 25956922)
J Cardiovasc Dev Dis. 2020 Dec 16;7(4):. (PMID: 33339213)
Ann Thorac Surg. 2018 Apr;105(4):1144-1151. (PMID: 29248417)
Gene. 2016 Jul 15;586(1):56-61. (PMID: 27063507)
Cardiovasc Res. 2020 Apr 1;116(5):931-943. (PMID: 31497851)
Circ Res. 2006 Oct 13;99(8):861-9. (PMID: 16973908)
J Cardiovasc Dev Dis. 2021 Aug 20;8(8):. (PMID: 34436240)
Curr Cardiol Rep. 2011 Apr;13(2):113-20. (PMID: 21221857)
J Mech Behav Biomed Mater. 2022 Oct;134:105401. (PMID: 35944442)
Circ Cardiovasc Imaging. 2018 Jan;11(1):e005971. (PMID: 29321211)
J Biomed Mater Res. 1998 Jul;41(1):131-41. (PMID: 9641633)
Nat Rev Cardiol. 2015 Dec;12(12):689-710. (PMID: 26483167)
Development. 1989 Jan;105(1):61-74. (PMID: 2806118)
J Am Coll Cardiol. 2014 Apr 29;63(16):1667-74. (PMID: 24316086)
J Biomech Eng. 2007 Feb;129(1):78-87. (PMID: 17227101)
Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H1983-90. (PMID: 22345569)
Acta Biomater. 2018 Feb;67:248-258. (PMID: 29199067)
Sci Rep. 2022 Jun 1;12(1):9159. (PMID: 35650306)
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):19943-8. (PMID: 22123981)
Nat Neurosci. 2013 Aug;16(8):1154-61. (PMID: 23792946)
Circulation. 2002 Sep 10;106(11):1355-61. (PMID: 12221052)
J R Soc Interface. 2012 Dec 26;10(80):20120760. (PMID: 23269845)
Cell. 2015 Jul 16;162(2):246-257. (PMID: 26186186)
J Cardiovasc Dev Dis. 2021 Feb 22;8(2):. (PMID: 33671724)
Front Cardiovasc Med. 2023 Feb 16;10:1077788. (PMID: 36873395)
Cardiovasc Res. 2006 Aug 1;71(3):548-56. (PMID: 16740254)
Lancet. 2009 Apr 18;373(9672):1382-94. (PMID: 19356795)
Cardiovasc Pathol. 1999 Mar-Apr;8(2):81-92. (PMID: 10724505)
Acta Biomater. 2016 Mar 1;32:238-255. (PMID: 26712602)
J Am Coll Cardiol. 2003 Jul 16;42(2):271-7. (PMID: 12875763)
JTCVS Open. 2023 Jan 23;13:95-105. (PMID: 37063127)
Acta Biomater. 2022 Mar 15;141:244-254. (PMID: 35007783)
Biochem J. 1984 Apr 15;219(2):451-60. (PMID: 6430269)
J Thorac Cardiovasc Surg. 2008 Feb;135(2):274-82. (PMID: 18242250)
Circulation. 2001 Nov 20;104(21):2525-32. (PMID: 11714645)
Am J Pathol. 2007 Nov;171(5):1407-18. (PMID: 17823281)
Acta Biomater. 2023 Jul 1;164:269-281. (PMID: 37003496)
Eur Heart J. 2010 Aug;31(16):1958-66. (PMID: 20624767)
Circulation. 2006 Mar 14;113(10):1344-52. (PMID: 16534030)
J Theor Biol. 2015 May 21;373:26-39. (PMID: 25791285)
Acta Biomater. 2020 Jan 15;102:149-168. (PMID: 31734412)
Semin Thorac Cardiovasc Surg. 2007 Summer;19(2):90-6. (PMID: 17870001)
Acta Biomater. 2019 Feb;85:241-252. (PMID: 30579963)
J Thorac Cardiovasc Surg. 2001 Nov;122(5):955-62. (PMID: 11689801)
Immunology. 2006 May;118(1):10-24. (PMID: 16630019)
J Thorac Cardiovasc Surg. 2014 Sep;148(3):1025-34; discussion 1034. (PMID: 25052823)
Circ Cardiovasc Imaging. 2011 Jan;4(1):24-32. (PMID: 20884831)
Cardiovasc Pathol. 2012 Jan-Feb;21(1):46-58. (PMID: 21349746)
APMIS. 2012 Jun;120(6):484-94. (PMID: 22583361)
Am Heart J. 1995 Jun;129(6):1149-58. (PMID: 7754947)
J Mol Cell Cardiol. 2019 Oct;135:149-159. (PMID: 31442470)
J Saudi Heart Assoc. 2020 May 20;32(2):224-232. (PMID: 33154921)
JTCVS Tech. 2022 Oct 01;16:49-59. (PMID: 36510522)
Semin Thorac Cardiovasc Surg. 2016 Winter;28(4):757-767. (PMID: 28417861)

Keywords: Barlow’s disease; Collagen remodeling; Degenerative mitral valve disease; Fibroelastic deficiency

9007-34-5 (Collagen)

Barlow syndrome

Date Created: 20240708 Date Completed: 20240708 Latest Revision: 20240729

20250114

PMC11231298

10.1038/s41598-024-65598-w

38977735