Concepts and Approaches to Reduce or Avoid Protein Corona Formation on Nanoparticles: Challenges and Opportunities.

Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

Original Publication: Weinheim : WILEY-VCH, [2014]-

Protein Corona*/chemistry ; Nanoparticles*/chemistry; Humans ; Nanomedicine/methods ; Blood Proteins/chemistry

This review describes the formation of a protein corona (or its absence) on different classes of nanoparticles, its basic principles, and its consequences for nanomedicine. For this purpose, it describes general concepts to control (guide/minimize) the interaction between artificial nanoparticles and plasma proteins to reduce protein corona formation. Thereafter, methods for the qualitative or quantitative determination of protein corona formation are presented, as well as the properties of nanoparticle surfaces, which are relevant for protein corona prevention (or formation). Thereby especially the role of grafting density of hydrophilic polymers on the surface of the nanoparticle is discussed to prevent the formation of a protein corona. In this context also the potential of detergents (surfactants) for a temporary modification as well as grafting-to and grafting-from approaches for a permanent modification of the surface are discussed. The review concludes by highlighting several promising avenues. This includes (i) the use of nanoparticles without protein corona for active targeting, (ii) the use of synthetic nanoparticles without protein corona formation to address the immune system, (iii) the recollection of nanoparticles with a defined protein corona after in vivo application to sample the blood proteome and (iv) further concepts to reduce protein corona formation.
(© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)

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Deutsche Forschungsgemeinschaft, DFG Cluster of Excellence 'Advanced Imaging of Matter' - EXC 2056 (Germany); SFB 1066 Coordinated Research Center; 390 715 994 Coordinated Research Center

Keywords: nano particles; nanomedicine; protein corona; surface modification

0 (Protein Corona)
0 (Blood Proteins)

Date Created: 20240708 Date Completed: 20240926 Latest Revision: 20240928

20240928

PMC11425909

10.1002/advs.202402935

38976560