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[The viral protein NS1: a major player in the pathogenesis of orthoflaviviruses].

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  • المؤلفون: Revel J;Revel J; Desmetz C; Desmetz C; Simonin Y; Simonin Y
  • المصدر:
    Virologie (Montrouge, France) [Virologie (Montrouge)] 2024 Jun 01; Vol. 28 (3), pp. 187-197.
  • نوع النشر :
    Journal Article; Review; English Abstract
  • اللغة:
    French
  • معلومة اضافية
    • Transliterated Title:
      La protéine virale NS1 : un acteur majeur de la pathogenèse des orthoflavivirus.
    • المصدر:
      Publisher: John Libbey Eurotext Country of Publication: France NLM ID: 9802575 Publication Model: Print Cited Medium: Internet ISSN: 1267-8694 (Print) Linking ISSN: 12678694 NLM ISO Abbreviation: Virologie (Montrouge) Subsets: MEDLINE
    • بيانات النشر:
      Publication: Montrouge : John Libbey Eurotext
      Original Publication: Montrouge, France : John Libbey Eurotext, [1997?-
    • الموضوع:
      Viral Nonstructural Proteins*/metabolism ; Viral Nonstructural Proteins*/physiology ; Virus Replication*; Humans ; Animals ; Flavivirus Infections/virology ; Immune Evasion ; Flavivirus/physiology ; Flavivirus/pathogenicity ; Zika Virus/physiology ; Zika Virus/pathogenicity ; Dengue Virus/physiology
    • نبذة مختصرة :
      Orthoflaviviruses are enveloped positive-sense RNA viruses comprising numerous human pathogens transmitted by hematophagous arthropods. This includes viruses such as dengue virus, Zika virus, and yellow fever virus. The viral nonstructural protein NS1 plays a central role in the pathogenesis and cycle of these viruses by acting in two different forms: associated with the plasma membrane (NS1m) or secreted outside the cell (NS1s). The versatility of NS1 is evident in its ability to modulate various aspects of the infectious process, from immune evasion to pathogenesis. As an intracellular protein, it disrupts many processes, interfering with signaling pathways and facilitating viral replication in concert with other viral proteins. As a secreted protein, NS1 actively participates in immune evasion, interfering with the host immune system, inhibiting the complement system, facilitating viral dissemination, and disrupting the integrity of endothelial barriers. This review primarily aims to address the role of NS1 in viral pathogenesis associated with orthoflaviviruses.
    • Contributed Indexing:
      Keywords: Flavivirus; NS1; Orthoflaviviruses; Zika; dengue; viral pathogenesis
    • الرقم المعرف:
      0 (Viral Nonstructural Proteins)
    • الموضوع:
      Date Created: 20240706 Date Completed: 20240706 Latest Revision: 20240801
    • الموضوع:
      20240801
    • الرقم المعرف:
      10.1684/vir.2024.1050
    • الرقم المعرف:
      38970340