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Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model.

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  • معلومة اضافية
    • المصدر:
      Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
    • بيانات النشر:
      Publication: : Washington, DC : American Association for the Advancement of Science
      Original Publication: New York, N.Y. : [s.n.] 1880-
    • الموضوع:
      Calcitonin Gene-Related Peptide*/cerebrospinal fluid ; Calcitonin Gene-Related Peptide*/metabolism ; Cortical Spreading Depression* ; Migraine Disorders*/cerebrospinal fluid ; Migraine Disorders*/metabolism ; Migraine Disorders*/physiopathology ; Trigeminal Ganglion*/metabolism ; Trigeminal Ganglion*/physiopathology; Animals ; Mice ; Cerebrospinal Fluid/metabolism ; Disease Models, Animal ; Proteome/metabolism ; Signal Transduction
    • نبذة مختصرة :
      Classical migraine patients experience aura, which is transient neurological deficits associated with cortical spreading depression (CSD), preceding headache attacks. It is not currently understood how a pathological event in cortex can affect peripheral sensory neurons. In this study, we show that cerebrospinal fluid (CSF) flows into the trigeminal ganglion, establishing nonsynaptic signaling between brain and trigeminal cells. After CSD, ~11% of the CSF proteome is altered, with up-regulation of proteins that directly activate receptors in the trigeminal ganglion. CSF collected from animals exposed to CSD activates trigeminal neurons in naïve mice in part by CSF-borne calcitonin gene-related peptide (CGRP). We identify a communication pathway between the central and peripheral nervous system that might explain the relationship between migrainous aura and headache.
    • Comments:
      Comment in: Science. 2024 Jul 5;385(6704):28-29. doi: 10.1126/science.adq3498. (PMID: 38963860)
    • الرقم المعرف:
      JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
      0 (Proteome)
    • الموضوع:
      Date Created: 20240704 Date Completed: 20240704 Latest Revision: 20240708
    • الموضوع:
      20240709
    • الرقم المعرف:
      10.1126/science.adl0544
    • الرقم المعرف:
      38963846