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Bridging the gap: understanding contemporary autopsies in acute leukemia by comparing ante-mortem and post-mortem profiles.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Taylor & Francis Country of Publication: United States NLM ID: 9007422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2403 (Electronic) Linking ISSN: 10268022 NLM ISO Abbreviation: Leuk Lymphoma Subsets: MEDLINE
    • بيانات النشر:
      Publication: [Philadelphia, PA] : Taylor & Francis
      Original Publication: Chur ; New York : London, UK : Harwood Academic Publishers ; Distributed by STBS, 1989-
    • الموضوع:
      Autopsy* ; Leukemia, Myeloid, Acute*/pathology ; Leukemia, Myeloid, Acute*/mortality ; Leukemia, Myeloid, Acute*/diagnosis; Humans ; Male ; Middle Aged ; Female ; Adult ; Adolescent ; Aged ; Young Adult ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/mortality ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Cause of Death ; Aged, 80 and over ; Neoplasm, Residual ; Child
    • نبذة مختصرة :
      This study investigates acute myeloid leukemia/lymphoblastic leukemia (AML/ALL) through a 14-year analysis (2009-2022) of 46 autopsied cases (age >12 years). B-ALL was the dominant subtype (34.8%). Liver and spleen were the common sites of active leukemia (63% cases). Symptoms like dyspnea and altered sensorium associated significantly with heart ( p  = .031) and brain leukostasis ( p  = .006). Measurable residual disease (MRD) negativity correlated with disease-free status outside the bone marrow, while MRD-positive cases displayed leukemic infiltrates. Infections were identified in 23 autopsied cases, notably linked to post-induction and post-transplant fatalities. Surprisingly, 18 of these 23 cases had unexpected infections mainly fungal (13 cases) with Aspergillus species as the most common. Diagnostic discrepancies were identified in 48% of cases. Malignant infiltration (46%) and infections (25%) were the leading causes of death. This research sheds light on leukemia in extra-medullary tissues, uncovers novel clinical-pathological associations, and highlights overlooked therapy side effects, offering insights for future case management.
    • Contributed Indexing:
      Keywords: Acute leukemia; autopsy; discrepancy; histopathology
    • الموضوع:
      Date Created: 20240701 Date Completed: 20241110 Latest Revision: 20241110
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1080/10428194.2024.2372408
    • الرقم المعرف:
      38949830