Significance of Cellular Lipid Metabolism for the Replication of Rotaviruses and Other RNA Viruses.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI

Virus Replication* ; Rotavirus*/metabolism ; Rotavirus*/physiology ; Rotavirus*/genetics ; Lipid Metabolism* ; RNA Viruses*/metabolism ; RNA Viruses*/genetics ; RNA Viruses*/physiology; Humans ; Lipid Droplets/metabolism ; Lipid Droplets/virology ; Animals

The replication of species A rotaviruses (RVAs) involves the recruitment of and interaction with cellular organelles' lipid droplets (LDs), both physically and functionally. The inhibition of enzymes involved in the cellular fatty acid biosynthesis pathway or the inhibition of cellular lipases that degrade LDs was found to reduce the functions of 'viral factories' (viroplasms for rotaviruses or replication compartments of other RNA viruses) and decrease the production of infectious progeny viruses. While many other RNA viruses utilize cellular lipids for their replication, their detailed analysis is far beyond this review; only a few annotations are made relating to hepatitis C virus (HCV), enteroviruses, SARS-CoV-2, and HIV-1.

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Keywords: HIV-1; RNA virus replication; SARS-CoV-2; enteroviruses; hepatitis C virus; lipid metabolism; rotavirus

Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629

20240629

PMC11209218

10.3390/v16060908

38932200