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Effects of Bifidobacterium longum 35624 in Children and Adolescents with Irritable Bowel Syndrome.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Basel, Switzerland : MDPI Publishing
    • الموضوع:
      Irritable Bowel Syndrome*/microbiology ; Probiotics*/therapeutic use ; Bifidobacterium longum*; Humans ; Adolescent ; Child ; Male ; Female ; Chile ; Treatment Outcome ; Severity of Illness Index ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/drug therapy
    • نبذة مختصرة :
      Irritable bowel syndrome (IBS) and vitamin D deficiency are common among children in Latin America. Previous studies show that Bifidobacterium longum 35624 TM improves IBS symptoms in adults. This real-world, single-arm, open-label study conducted in Chile investigated the effects of B. longum 35624 (1 × 10 9 colony-forming units, 12 weeks) on gastrointestinal symptoms (adapted IBS severity scoring system [IBS-SSS]; adapted Questionnaire on Pediatric Gastrointestinal Symptoms [QPGS], and Bristol Stool Form Scale) in 64 children and adolescents (8-18 years) and explored the relationship with baseline vitamin D status. Improvements in all IBS-SSS domains and composite score were observed at week 6 and 12 ( p < 0.0007 versus baseline), with 98.3% of participants experiencing numerical improvements in ≥3 domains. Clinically meaningful improvement was seen in 96.6% of participants. The distribution of IBS-SSS severity categories shifted from moderate/severe at baseline to mild/remission ( p < 0.0001). Improvements were not maintained during the two-week washout. Low baseline serum vitamin D levels did not correlate to IBS severity or probiotic response. QPGS significantly decreased from baseline to week 6 ( p = 0.0005) and 12 ( p = 0.02). B. longum 35624 may improve IBS symptoms in children and adolescents, even those with vitamin D deficiency. A confirmatory randomized controlled trial and further exploration of probiotic response and vitamin D status are needed.
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    • Grant Information:
      n/a Novozymes (Denmark); n/a Biocodex (France)
    • Contributed Indexing:
      Keywords: bifidobacteria; disorders of gut–brain interaction; irritable bowel syndrome; pediatrics; probiotics
    • الرقم المعرف:
      1406-16-2 (Vitamin D)
    • الموضوع:
      Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629
    • الموضوع:
      20240629
    • الرقم المعرف:
      PMC11206369
    • الرقم المعرف:
      10.3390/nu16121967
    • الرقم المعرف:
      38931319