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Towards Healthy Longevity: Comprehensive Insights from Molecular Targets and Biomarkers to Biological Clocks.
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- المؤلفون: Yusri K;Yusri K;Yusri K; Kumar S; Kumar S; Kumar S; Fong S; Fong S; Fong S; Gruber J; Gruber J; Gruber J; Gruber J; Sorrentino V; Sorrentino V; Sorrentino V; Sorrentino V
- المصدر:
International journal of molecular sciences [Int J Mol Sci] 2024 Jun 20; Vol. 25 (12). Date of Electronic Publication: 2024 Jun 20.- نوع النشر :
Journal Article; Review- اللغة:
English - المصدر:
- معلومة اضافية
- المصدر: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
- بيانات النشر: Original Publication: Basel, Switzerland : MDPI, [2000-
- الموضوع:
- نبذة مختصرة : Aging is a complex and time-dependent decline in physiological function that affects most organisms, leading to increased risk of age-related diseases. Investigating the molecular underpinnings of aging is crucial to identify geroprotectors, precisely quantify biological age, and propose healthy longevity approaches. This review explores pathways that are currently being investigated as intervention targets and aging biomarkers spanning molecular, cellular, and systemic dimensions. Interventions that target these hallmarks may ameliorate the aging process, with some progressing to clinical trials. Biomarkers of these hallmarks are used to estimate biological aging and risk of aging-associated disease. Utilizing aging biomarkers, biological aging clocks can be constructed that predict a state of abnormal aging, age-related diseases, and increased mortality. Biological age estimation can therefore provide the basis for a fine-grained risk stratification by predicting all-cause mortality well ahead of the onset of specific diseases, thus offering a window for intervention. Yet, despite technological advancements, challenges persist due to individual variability and the dynamic nature of these biomarkers. Addressing this requires longitudinal studies for robust biomarker identification. Overall, utilizing the hallmarks of aging to discover new drug targets and develop new biomarkers opens new frontiers in medicine. Prospects involve multi-omics integration, machine learning, and personalized approaches for targeted interventions, promising a healthier aging population.
- References: Nature. 2023 Dec;624(7990):164-172. (PMID: 38057571)
Nat Med. 2016 Aug;22(8):879-88. (PMID: 27400265)
Nat Commun. 2014 May 12;5:3837. (PMID: 24815183)
Chem Biol Interact. 2022 Jan 5;351:109741. (PMID: 34752757)
Diabetes. 2013 Apr;62(4):1084-93. (PMID: 23172919)
Nat Med. 2023 May;29(5):1221-1231. (PMID: 37024597)
Aging (Albany NY). 2016 Jul;8(7):1316-29. (PMID: 27288264)
Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4104-10. (PMID: 26150497)
J Vis Exp. 2017 May 1;(123):. (PMID: 28518126)
Nutrients. 2020 Aug 24;12(9):. (PMID: 32846900)
Sci Adv. 2022 Oct 21;8(42):eadd6155. (PMID: 36260671)
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17350-5. (PMID: 24082110)
Aging Cell. 2017 Apr;16(2):329-338. (PMID: 28058805)
Cell Rep. 2019 Apr 9;27(2):467-480.e6. (PMID: 30970250)
Aging Cell. 2017 Jun;16(3):564-574. (PMID: 28371119)
J Gerontol A Biol Sci Med Sci. 2021 Jun 14;76(7):1206-1213. (PMID: 33491048)
Aging Cell. 2012 Dec;11(6):960-7. (PMID: 22834969)
J Clin Endocrinol Metab. 2006 Sep;91(9):3303-9. (PMID: 16757523)
Mech Ageing Dev. 2015 Nov;151:2-12. (PMID: 25818235)
Cell. 2010 Nov 24;143(5):813-25. (PMID: 21111239)
Int J Mol Sci. 2019 Sep 20;20(19):. (PMID: 31547084)
Nat Rev Cancer. 2015 Jul;15(7):397-408. (PMID: 26105537)
Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):4252-9. (PMID: 27036001)
Cell. 2019 Jan 10;176(1-2):11-42. (PMID: 30633901)
J Gerontol A Biol Sci Med Sci. 2007 Oct;62(10):1096-105. (PMID: 17921421)
Geroscience. 2021 Dec;43(6):2795-2808. (PMID: 34725754)
Nat Cell Biol. 2015 Aug;17(8):1049-61. (PMID: 26147250)
Nat Aging. 2021 Dec;1(12):1189-1201. (PMID: 36211119)
Aging (Albany NY). 2022 Dec 14;14(23):9484-9549. (PMID: 36516495)
Ageing Res Rev. 2023 Aug;89:101985. (PMID: 37321382)
Front Genet. 2018 Jul 12;9:242. (PMID: 30050560)
BMJ. 2020 Oct 7;371:m3485. (PMID: 33028588)
Cell. 2019 Oct 31;179(4):813-827. (PMID: 31675495)
Mech Ageing Dev. 2006 Mar;127(3):240-8. (PMID: 16318865)
Nat Metab. 2019 Dec;1(12):1219-1225. (PMID: 32694678)
Nature. 2021 Mar;591(7848):117-123. (PMID: 33442062)
Front Nutr. 2022 Sep 08;9:958563. (PMID: 36159455)
Genes Dev. 2015 May 15;29(10):989-99. (PMID: 25995186)
Nature. 2001 Feb 22;409(6823):1067-70. (PMID: 11234019)
Annu Rev Pathol. 2010;5:99-118. (PMID: 20078217)
Aging Cell. 2012 Oct;11(5):801-9. (PMID: 22681576)
Nat Metab. 2023 Dec;5(12):2047-2061. (PMID: 38036770)
Elife. 2020 Nov 19;9:. (PMID: 33210602)
Sci China Life Sci. 2023 May;66(5):893-1066. (PMID: 37076725)
PLoS Med. 2018 Dec 31;15(12):e1002718. (PMID: 30596641)
Exp Gerontol. 2000 Sep;35(6-7):767-77. (PMID: 11053667)
Nat Commun. 2022 Jul 7;13(1):3775. (PMID: 35798717)
Nat Commun. 2013;4:2192. (PMID: 23900241)
Nat Aging. 2024 Jun 19;:. (PMID: 38898237)
Aging Cell. 2020 Feb;19(2):e13080. (PMID: 31833194)
Molecules. 2022 Jan 23;27(3):. (PMID: 35164003)
Cell. 2013 Jun 6;153(6):1194-217. (PMID: 23746838)
Biochim Biophys Acta. 2015 Nov;1847(11):1347-53. (PMID: 26050973)
Front Immunol. 2020 Nov 30;11:597959. (PMID: 33329591)
Transl Oncol. 2022 Jan;15(1):101300. (PMID: 34864401)
Nat Metab. 2020 Sep;2(9):946-957. (PMID: 32895578)
Aging (Albany NY). 2018 Apr 18;10(4):573-591. (PMID: 29676998)
Signal Transduct Target Ther. 2023 Aug 16;8(1):304. (PMID: 37582956)
Anal Biochem. 2006 May 15;352(2):274-81. (PMID: 16600169)
Int J Epidemiol. 2013 Aug;42(4):1111-9. (PMID: 23838602)
J Cell Physiol. 2007 Mar;210(3):567-74. (PMID: 17133363)
Am J Clin Nutr. 2011 Feb;93(2):402-12. (PMID: 21159787)
Cell Metab. 2020 Nov 3;32(5):814-828.e6. (PMID: 32949498)
Nature. 2018 Jun;558(7708):73-79. (PMID: 29875488)
Compr Physiol. 2014 Jul;4(3):1201-28. (PMID: 24944035)
Clin Cancer Res. 2011 Aug 1;17(15):5132-9. (PMID: 21558407)
Muscle Nerve. 2021 Feb;63(2):239-249. (PMID: 33125736)
Cell Metab. 2017 Apr 4;25(4):954-960.e6. (PMID: 28380383)
J Prev Alzheimers Dis. 2020;7(1):56-64. (PMID: 32010927)
Nat Rev Cardiol. 2018 Sep;15(9):505-522. (PMID: 30065258)
Nat Commun. 2021 Sep 3;12(1):5213. (PMID: 34480023)
NPJ Aging. 2023 Jul 1;9(1):13. (PMID: 37393295)
Lancet. 1969 Dec 27;2(7635):1411-4. (PMID: 4188291)
Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E224-32. (PMID: 26037248)
Gerontology. 2008;54(2):92-9. (PMID: 18451641)
Exp Gerontol. 2008 Jan;43(1):24-33. (PMID: 17997255)
Aging (Albany NY). 2018 Oct 21;10(10):2832-2854. (PMID: 30348905)
Eur J Nutr. 2020 Mar;59(2):505-515. (PMID: 30725213)
Age (Dordr). 2011 Jun;33(2):219-27. (PMID: 20811950)
J Clin Endocrinol Metab. 2018 Apr 1;103(4):1282-1290. (PMID: 29425296)
Cell. 2014 Nov 6;159(4):709-13. (PMID: 25417146)
ACS Chem Biol. 2017 Sep 15;12(9):2240-2247. (PMID: 28719185)
F1000Res. 2017 Jun 9;6:860. (PMID: 28663789)
Geroscience. 2022 Dec;44(6):2573-2583. (PMID: 36242692)
Biogerontology. 2020 Dec;21(6):773-786. (PMID: 32776262)
Biomed Pharmacother. 2019 Mar;111:1156-1165. (PMID: 30841429)
Aging Cell. 2019 Feb;18(1):e12844. (PMID: 30548452)
Twin Res Hum Genet. 2015 Dec;18(6):720-6. (PMID: 26527295)
Cell. 2023 Jan 19;186(2):243-278. (PMID: 36599349)
Nature. 2021 Apr;592(7856):695-703. (PMID: 33911272)
J Adv Res. 2021 Aug 11;37:267-278. (PMID: 35499054)
Nat Med. 2019 Dec;25(12):1843-1850. (PMID: 31806903)
Science. 2016 Jun 17;352(6292):1436-43. (PMID: 27127236)
Ageing Res Rev. 2011 Jul;10(3):319-29. (PMID: 21145432)
Exp Aging Res. 1983 Winter;9(4):225-38. (PMID: 6667706)
J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1913-1920. (PMID: 31179487)
Stem Cells Int. 2021 Feb 1;2021:6638249. (PMID: 33603790)
Aging (Albany NY). 2020 Apr 8;12(7):6401-6414. (PMID: 32268299)
Front Neurol. 2015 Nov 16;6:236. (PMID: 26635716)
FEBS Lett. 2018 Mar;592(5):743-758. (PMID: 29106705)
Biomed Pharmacother. 2021 May;137:111286. (PMID: 33524789)
Cell Death Differ. 2015 Mar;22(3):509-16. (PMID: 25526088)
Arch Gerontol Geriatr. 2009 Jul-Aug;49(1):7-12. (PMID: 18597867)
Front Biosci. 2008 May 01;13:6554-79. (PMID: 18508680)
JAMA Netw Open. 2022 Jan 4;5(1):e2144279. (PMID: 35050355)
Int J Biochem Cell Biol. 2003 May;35(5):728-39. (PMID: 12672464)
Stem Cell Rev Rep. 2024 Apr;20(3):816-826. (PMID: 38340274)
Dev Genet. 1996;18(2):173-9. (PMID: 8934879)
J Nutr Sci Vitaminol (Tokyo). 2001 Apr;47(2):177-9. (PMID: 11508711)
Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):E3470. (PMID: 27303027)
Annu Rev Nutr. 2008;28:115-30. (PMID: 18429699)
Invest Ophthalmol Vis Sci. 2002 Jan;43(1):198-204. (PMID: 11773032)
Geroscience. 2023 Aug;45(4):2689-2705. (PMID: 37086366)
Curr Biol. 2017 Sep 11;27(17):2652-2660.e4. (PMID: 28844647)
Antioxidants (Basel). 2023 Mar 06;12(3):. (PMID: 36978899)
Front Cell Neurosci. 2015 Jan 08;8:443. (PMID: 25620911)
Mol Cell. 2013 Jan 24;49(2):359-367. (PMID: 23177740)
Aging Cell. 2021 Oct;20(10):e13439. (PMID: 34535961)
Ageing Res Rev. 2020 Jul;60:101050. (PMID: 32272169)
EBioMedicine. 2019 Sep;47:446-456. (PMID: 31542391)
Antioxidants (Basel). 2021 May 17;10(5):. (PMID: 34067882)
Nat Med. 2020 Aug;26(8):1256-1263. (PMID: 32572268)
Nat Commun. 2019 Nov 21;10(1):5284. (PMID: 31754102)
Antioxidants (Basel). 2022 Jan 14;11(1):. (PMID: 35052660)
J Gerontol A Biol Sci Med Sci. 1999 Nov;54(11):B464-5. (PMID: 10619309)
Biochem J. 2012 Jan 15;441(2):523-40. (PMID: 22187934)
Am J Physiol Endocrinol Metab. 2004 Mar;286(3):E321-8. (PMID: 14583440)
Biology (Basel). 2020 Dec 21;9(12):. (PMID: 33371508)
Circulation. 2014 Jun 24;129(25 Suppl 2):S49-73. (PMID: 24222018)
EMBO J. 2012 Mar 7;31(5):1095-108. (PMID: 22343943)
Autophagy. 2007 Jan-Feb;3(1):10-6. (PMID: 16963840)
Front Physiol. 2018 Feb 05;9:44. (PMID: 29459830)
Cell Syst. 2021 Aug 18;12(8):759-770. (PMID: 34411543)
Trends Biochem Sci. 1990 Aug;15(8):305-9. (PMID: 2204156)
J Gerontol A Biol Sci Med Sci. 2015 Jul;70(7):809-16. (PMID: 25123647)
Lancet Healthy Longev. 2023 Dec;4(12):e711-e723. (PMID: 37944549)
Cell Metab. 2022 Mar 1;34(3):396-407.e6. (PMID: 35235774)
Aging Dis. 2017 May 2;8(3):354-363. (PMID: 28580190)
Trends Biochem Sci. 2017 Sep;42(9):712-725. (PMID: 28579074)
Elife. 2022 Jan 14;11:. (PMID: 35029144)
Nat Med. 2023 Sep;29(9):2162-2165. (PMID: 37468667)
Cell Cycle. 2018;17(9):1048-1055. (PMID: 29886783)
Eur J Pharmacol. 2018 Mar 5;822:95-107. (PMID: 29355558)
Mitochondrion. 2023 Mar;69:1-9. (PMID: 36273801)
Genome Res. 2008 Apr;18(4):564-70. (PMID: 18340043)
Histol Histopathol. 2007 Sep;22(9):971-6. (PMID: 17523074)
Circulation. 2021 Feb 9;143(6):606-608. (PMID: 33190524)
PLoS Comput Biol. 2019 Jul 3;15(7):e1007162. (PMID: 31269015)
EBioMedicine. 2019 Feb;40:554-563. (PMID: 30616998)
Front Endocrinol (Lausanne). 2020 Aug 27;11:560. (PMID: 32982966)
Nat Med. 2015 Dec;21(12):1424-35. (PMID: 26646499)
Nat Med. 2018 Nov;24(11):1696-1700. (PMID: 30250143)
Stem Cell Rev Rep. 2019 Jun;15(3):448-455. (PMID: 30790135)
Autophagy. 2019 Apr;15(4):631-651. (PMID: 30335591)
Nat Aging. 2021 Mar;1(3):295-308. (PMID: 33796868)
Brain Res Brain Res Protoc. 2003 Feb;10(3):168-74. (PMID: 12565687)
Cas Lek Cesk. 2023 Fall;162(5):194-202. (PMID: 37923561)
Ann N Y Acad Sci. 2022 Jan;1507(1):70-83. (PMID: 34498278)
Bioessays. 2016 Jul;38 Suppl 1:S56-64. (PMID: 27417123)
J Gerontol A Biol Sci Med Sci. 2004 Jun;59(6):B560-7. (PMID: 15215265)
Neurology. 2012 Feb 28;78(9):658-64. (PMID: 22371413)
J Cell Commun Signal. 2018 Mar;12(1):309-318. (PMID: 29247377)
Hypertension. 2018 Jun;71(6):1056-1063. (PMID: 29661838)
Science. 1998 Nov 20;282(5393):1497-501. (PMID: 9822382)
J Chromatogr B Analyt Technol Biomed Life Sci. 2003 May 5;788(1):103-11. (PMID: 12668076)
Nat Aging. 2021 Jul;1:598-615. (PMID: 34888528)
Sci Rep. 2020 Jul 1;10(1):10752. (PMID: 32612244)
Nat Med. 2008 Sep;14(9):959-65. (PMID: 18690243)
Autophagy. 2012 Apr;8(4):445-544. (PMID: 22966490)
Aging Cell. 2024 Jan;23(1):e13920. (PMID: 37424179)
Geroscience. 2018 Dec;40(5-6):419-436. (PMID: 30151729)
Aging (Albany NY). 2024 Feb 22;16(4):3088-3106. (PMID: 38393697)
FEBS J. 2021 Jan;288(1):56-80. (PMID: 32961620)
Clin Cancer Res. 2012 Jul 1;18(13):3580-91. (PMID: 22586301)
Metabolites. 2019 Mar 05;9(3):. (PMID: 30841604)
Exp Gerontol. 2023 Jun 15;177:112176. (PMID: 37080342)
Nature. 2014 May 22;509(7501):439-46. (PMID: 24848057)
Aging Cell. 2015 Aug;14(4):644-58. (PMID: 25754370)
Theranostics. 2021 Mar 31;11(12):5675-5685. (PMID: 33897874)
Nat Aging. 2023 Sep;3(9):1144-1166. (PMID: 37563227)
Alzheimers Res Ther. 2019 Mar 21;11(1):28. (PMID: 30902061)
NPJ Aging. 2022 May 1;8(1):5. (PMID: 35927255)
Nature. 2017 Dec 14;552(7684):187-193. (PMID: 29211722)
Aging Cell. 2020 Nov;19(11):e13250. (PMID: 33089916)
Nat Commun. 2024 Feb 3;15(1):1041. (PMID: 38310113)
Mayo Clin Proc. 2021 Mar;96(3):788-814. (PMID: 33673927)
J Gerontol A Biol Sci Med Sci. 2019 Nov 13;74(Suppl_1):S52-S60. (PMID: 31724055)
FEBS J. 2020 Jun;287(12):2418-2427. (PMID: 32112672)
Neurosignals. 2014;22(1):52-63. (PMID: 25095809)
Ann Med. 2004;36(4):285-95. (PMID: 15224655)
Psychoneuroendocrinology. 2019 Aug;106:171-178. (PMID: 30999227)
Geroscience. 2022 Dec;44(6):2685-2699. (PMID: 36151431)
Lancet Healthy Longev. 2021 May;2(5):e250-e262. (PMID: 33977284)
Amino Acids. 2013 Jun;44(6):1493-509. (PMID: 23563921)
Nat Commun. 2017 Feb 06;8:14338. (PMID: 28165011)
J Clin Endocrinol Metab. 2012 Jan;97(1):242-50. (PMID: 22049170)
Nat Med. 2018 Aug;24(8):1246-1256. (PMID: 29988130)
Aging Cell. 2021 Dec;20(12):e13486. (PMID: 34734460)
Front Genet. 2019 May 14;10:435. (PMID: 31139208)
Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):45-9. (PMID: 18090658)
Semin Cell Dev Biol. 2021 Aug;116:180-193. (PMID: 33509689)
Cell Res. 2014 Jan;24(1):24-41. (PMID: 24366339)
Cancer Res. 1995 Jun 1;55(11):2284-92. (PMID: 7757977)
Biogerontology. 2019 Feb;20(1):1-16. (PMID: 30229407)
Front Genet. 2018 Oct 23;9:483. (PMID: 30405692)
Commun Biol. 2023 Oct 26;6(1):1089. (PMID: 37884697)
Curr Oncol Rep. 2021 Jul 16;23(9):104. (PMID: 34269912)
Nat Rev Mol Cell Biol. 2018 Jun;19(6):365-381. (PMID: 29626215)
Nat Protoc. 2021 May;16(5):2471-2498. (PMID: 33911261)
Cortex. 2018 Dec;109:181-188. (PMID: 30388439)
Aging Cell. 2018 Apr;17(2):. (PMID: 29383869)
Aging Cell. 2020 Jun;19(6):e13149. (PMID: 32363781)
Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:353-389. (PMID: 28961065)
Biol Chem. 2008 Mar;389(3):211-20. (PMID: 18208352)
Mol Cell Endocrinol. 2017 Nov 5;455:13-22. (PMID: 27884780)
Nat Commun. 2020 Jul 30;11(1):3820. (PMID: 32732919)
Genes Dev. 2014 Jan 15;28(2):99-114. (PMID: 24449267)
Biochim Biophys Acta Mol Basis Dis. 2022 Jul 1;1868(7):166402. (PMID: 35346820)
Pharmacol Res Perspect. 2023 Jun;11(3):e01091. (PMID: 37190667)
Front Genet. 2021 May 21;12:686320. (PMID: 34093670)
Nat Rev Mol Cell Biol. 2019 Jul;20(7):421-435. (PMID: 30733602)
Front Cardiovasc Med. 2020 Nov 23;7:601364. (PMID: 33330662)
Diab Vasc Dis Res. 2018 Jan;15(1):74-80. (PMID: 28976207)
Nature. 2014 Jul 24;511(7510):405-7. (PMID: 25056047)
Nat Cell Biol. 2010 Feb;12(2):119-31. (PMID: 20098416)
J Am Soc Mass Spectrom. 2019 Jun;30(6):987-1000. (PMID: 30847833)
Aging Cell. 2017 Feb;16(1):17-26. (PMID: 27660040)
Exp Gerontol. 2018 Jun;106:125-131. (PMID: 29486228)
Geroscience. 2023 Feb;45(1):29-43. (PMID: 36482258)
Front Mol Neurosci. 2018 Jan 17;11:3. (PMID: 29386996)
Front Cell Dev Biol. 2021 Jan 12;8:619126. (PMID: 33511130)
PLoS One. 2013;8(3):e58423. (PMID: 23516479)
Cell Signal. 2011 Mar;23(3):516-21. (PMID: 20851765)
Rejuvenation Res. 2019 Apr;22(2):121-130. (PMID: 30124109)
Curr Res Biotechnol. 2023;5:. (PMID: 38045568)
Nat Aging. 2022 Dec;2(12):1112-1129. (PMID: 37118547)
Geroscience. 2024 Apr;46(2):1671-1691. (PMID: 37721682)
Mech Ageing Dev. 2008 Jan-Feb;129(1-2):3-10. (PMID: 18215413)
Nat Aging. 2023 Mar;3(3):248-257. (PMID: 37118425)
Ageing Res Rev. 2020 Dec;64:101198. (PMID: 33132154)
Comput Struct Biotechnol J. 2013 May 27;4:e201301012. (PMID: 24688693)
J Biol Chem. 2022 Oct;298(10):102415. (PMID: 36007615)
Cell Rep Med. 2022 May 17;3(5):100633. (PMID: 35584623)
Aging Cell. 2020 Nov;19(11):e13261. (PMID: 33067900)
Curr Genomics. 2014 Feb;15(1):38-51. (PMID: 24653662)
Exp Gerontol. 1988;23(4-5):223-39. (PMID: 3058488)
Antioxidants (Basel). 2023 Aug 21;12(8):. (PMID: 37627641)
Geroscience. 2019 Dec;41(6):861-869. (PMID: 31761958)
Geroscience. 2024 Apr 9;:. (PMID: 38589672)
Int J Mol Sci. 2022 Aug 20;23(16):. (PMID: 36012652)
Mol Metab. 2023 Aug;74:101755. (PMID: 37329949)
Exp Gerontol. 2005 Oct;40(10):759-62. (PMID: 16154308)
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Aug 1;871(1):115-24. (PMID: 18650133)
Nat Commun. 2023 Nov 28;14(1):7793. (PMID: 38016950)
Circ Res. 2012 Jun 22;111(1):97-109. (PMID: 22723221)
Cold Spring Harb Perspect Biol. 2010 Dec;2(12):a004390. (PMID: 21123396)
Nature. 2013 Jan 17;493(7432):338-45. (PMID: 23325216)
Mech Ageing Dev. 1988 Dec;46(1-3):1-18. (PMID: 3226152)
Nat Metab. 2019 Jun;1(6):595-603. (PMID: 32694802)
Geroscience. 2023 Oct;45(5):2769-2783. (PMID: 37801202)
Antioxidants (Basel). 2021 Aug 21;10(8):. (PMID: 34439563)
Front Aging. 2022 May 05;3:851698. (PMID: 35821806)
Int J Mol Sci. 2023 Feb 03;24(3):. (PMID: 36769283)
Geroscience. 2023 Dec;45(6):3257-3265. (PMID: 37501048)
J Pathol. 2010 May;221(1):3-12. (PMID: 20225336)
Autophagy. 2021 Oct;17(10):3238-3255. (PMID: 33164641)
J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):286-92. (PMID: 19196637)
Aging (Albany NY). 2019 Feb 24;11(4):1262-1282. (PMID: 30799310)
Cell Rep. 2022 Mar 8;38(10):110459. (PMID: 35263580)
Cell Metab. 2020 Jul 7;32(1):44-55.e6. (PMID: 32402267)
J Med Chem. 2019 Jul 25;62(14):6469-6481. (PMID: 30839208)
EBioMedicine. 2018 Oct;36:18-28. (PMID: 30279143)
Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10. (PMID: 26578790)
Elife. 2020 May 05;9:. (PMID: 32367804)
PLoS One. 2013;8(3):e56564. (PMID: 23483888)
J Gerontol A Biol Sci Med Sci. 2019 Jul 12;74(8):1289-1295. (PMID: 30256904)
Nat Metab. 2024 Mar;6(3):433-447. (PMID: 38504132)
FEBS Lett. 2013 Jun 27;587(13):1988-96. (PMID: 23669359)
J Clin Invest. 2012 Jul;122(7):2601-12. (PMID: 22706308)
EMBO Rep. 2019 Dec 5;20(12):e48395. (PMID: 31667999)
Aging Cell. 2015 Apr;14(2):249-64. (PMID: 25620427)
Sci Rep. 2021 Sep 13;11(1):18135. (PMID: 34518599)
Physiol Rev. 1983 Oct;63(4):1420-80. (PMID: 6361812)
J Cell Biol. 2005 Nov 21;171(4):603-14. (PMID: 16286508)
Arch Gen Psychiatry. 2010 Sep;67(9):879-88. (PMID: 20819981)
Br J Pharmacol. 2008 Mar;153 Suppl 1:S68-75. (PMID: 18037924)
Nat Chem Biol. 2023 Apr;19(4):468-477. (PMID: 36635564)
Exp Ther Med. 2021 Nov;22(5):1326. (PMID: 34630680)
Aging (Albany NY). 2018 Dec 18;10(12):4269-4288. (PMID: 30562164)
Aging (Albany NY). 2018 Oct 25;10(10):2973-2990. (PMID: 30362959)
Aging (Albany NY). 2020 Oct 13;12(19):19756-19765. (PMID: 33049709)
J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1707-1713. (PMID: 34003967)
J Gerontol A Biol Sci Med Sci. 2002 Nov;57(11):M712-5. (PMID: 12403798)
Geroscience. 2023 Oct;45(5):2785-2803. (PMID: 37261678)
Aging Cell. 2023 Feb;22(2):e13767. (PMID: 36637079)
J Chromatogr. 1991 Sep 18;570(1):77-88. (PMID: 1797838)
Exp Gerontol. 2005 Oct;40(10):813-9. (PMID: 16154306)
F1000Res. 2017 Jul 25;6:1219. (PMID: 28781767)
Oxid Med Cell Longev. 2018 Jul 12;2018:8575263. (PMID: 30116495)
Nutrients. 2021 Dec 27;14(1):. (PMID: 35010977)
IUBMB Life. 2022 Apr;74(4):296-316. (PMID: 34889504)
EMBO J. 2021 Oct 1;40(19):e108863. (PMID: 34459017)
J Biochem. 2024 Apr 29;175(5):473-480. (PMID: 38348509)
Sci Adv. 2023 Jan 13;9(2):eadd5163. (PMID: 36638183)
Aging (Albany NY). 2019 Jan 21;11(2):303-327. (PMID: 30669119)
J Am Heart Assoc. 2013 Dec 05;2(6):e000542. (PMID: 24308938)
Science. 2008 Mar 7;319(5868):1352-5. (PMID: 18323444)
Biogerontology. 2024 Feb;25(1):161-175. (PMID: 37736858)
PLoS One. 2017 Aug 16;12(8):e0183228. (PMID: 28813537)
Nat Commun. 2018 Mar 29;9(1):1286. (PMID: 29599478)
Biochem J. 2002 Oct 1;367(Pt 1):163-8. (PMID: 12117413)
Exerc Sport Sci Rev. 2019 Jul;47(3):169-175. (PMID: 30998529)
Cell Res. 2014 Jul;24(7):787-95. (PMID: 24903109)
Cell. 2015 May 7;161(4):919-32. (PMID: 25957690)
Genome Biol. 2018 Dec 20;19(1):221. (PMID: 30567591)
PLoS Genet. 2010 Jul 29;6(7):e1001039. (PMID: 20686651)
J Biol Chem. 2007 Feb 23;282(8):5641-52. (PMID: 17182613)
Aging Cell. 2022 Oct;21(10):e13696. (PMID: 36052758)
EMBO J. 2011 Jun 1;30(11):2101-14. (PMID: 21468027)
iScience. 2023 Dec 02;27(1):108538. (PMID: 38230258)
Crit Rev Food Sci Nutr. 2024;64(16):5242-5268. (PMID: 36484738)
BMC Immunol. 2011 Mar 28;12:24. (PMID: 21443787)
Am J Epidemiol. 1999 Aug 15;150(4):341-53. (PMID: 10453810)
Cell Rep. 2014 Jun 12;7(5):1371-1380. (PMID: 24857655)
Nat Rev Genet. 2005 May;6(5):389-402. (PMID: 15861210)
Cells. 2021 Apr 13;10(4):. (PMID: 33924316)
Science. 2015 Dec 4;350(6265):1193-8. (PMID: 26785477)
Cell. 2013 Jul 18;154(2):430-41. (PMID: 23870130)
Sci Transl Med. 2018 Jul 11;10(449):. (PMID: 29997249)
Aging Cell. 2011 Aug;10(4):604-21. (PMID: 21426483)
J Physiol. 2000 Jul 1;526 Pt 1:203-10. (PMID: 10878112)
Trends Cell Biol. 2020 Feb;30(2):117-132. (PMID: 31917080)
Nat Rev Mol Cell Biol. 2019 Nov;20(11):665-680. (PMID: 31253954)
Nat Commun. 2017 Mar 17;8:14617. (PMID: 28303888)
Mol Med Rep. 2019 Oct;20(4):3701-3708. (PMID: 31485647)
Lancet. 1989 Mar 25;1(8639):642-5. (PMID: 2564461)
Nat Commun. 2019 Dec 20;10(1):5808. (PMID: 31862890)
Aging Cell. 2007 Dec;6(6):769-74. (PMID: 17925004)
Adv Exp Med Biol. 2019;1206:109-126. (PMID: 31776982)
J Clin Invest. 2014 Jan;124(1):169-73. (PMID: 24334456)
Autophagy. 2011 Jun;7(6):572-83. (PMID: 21325881)
J Gerontol A Biol Sci Med Sci. 2022 Apr 1;77(4):744-754. (PMID: 34382643)
Signal Transduct Target Ther. 2023 Jun 8;8(1):239. (PMID: 37291105)
J Clin Invest. 2004 Nov;114(9):1299-307. (PMID: 15520862)
Cell Metab. 2016 Feb 9;23(2):303-14. (PMID: 26686024)
Science. 2021 Jun 11;372(6547):1224-1229. (PMID: 33888596)
Gerontology. 2023;69(10):1167-1174. (PMID: 37166337)
Curr Opin Cell Biol. 2016 Apr;39:8-14. (PMID: 26827287)
J Gerontol A Biol Sci Med Sci. 2021 Apr 30;76(5):741-749. (PMID: 33211845)
Rejuvenation Res. 2016 Dec;19(6):478-484. (PMID: 26950204)
Biomedicines. 2021 Feb 06;9(2):. (PMID: 33562077)
Aging (Albany NY). 2016 Jul;8(7):1294-315. (PMID: 27391570)
J Biol Chem. 2000 Oct 6;275(40):31505-13. (PMID: 10806201)
Cell Rep. 2019 Aug 13;28(7):1717-1728.e6. (PMID: 31412242)
Science. 2015 Dec 4;350(6265):1208-13. (PMID: 26785480)
Cell Metab. 2018 May 01;27(5):1081-1095.e10. (PMID: 29719225)
Front Nutr. 2018 Nov 15;5:108. (PMID: 30498696)
NPJ Aging. 2024 Feb 1;10(1):7. (PMID: 38302501)
Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):3053-3062. (PMID: 31980526)
Nature. 2006 Nov 30;444(7119):633-7. (PMID: 17136093)
Anal Biochem. 2002 Jul 15;306(2):197-203. (PMID: 12123656)
J Med Chem. 2023 Sep 28;66(18):12762-12775. (PMID: 37696000)
JAMA Psychiatry. 2020 Nov 1;77(11):1172-1180. (PMID: 32609320)
Cells. 2022 Dec 22;12(1):. (PMID: 36611827)
Biomolecules. 2014 Sep 23;4(3):862-84. (PMID: 25250704)
Nat Aging. 2022 Mar;2(3):254-263. (PMID: 37118369)
Br J Cancer. 2007 Mar 12;96(5):686-91. (PMID: 17311013)
Aging Cell. 2019 Dec;18(6):e13048. (PMID: 31560163)
Aging Cell. 2018 Oct;17(5):e12799. (PMID: 29992704)
Aging Cell. 2020 Jan;19(1):e13073. (PMID: 31746094)
Aging Cell. 2016 Jun;15(3):407-15. (PMID: 26970234)
Geroscience. 2024 Feb;46(1):665-682. (PMID: 37994989)
Metabolomics. 2015;11:9-26. (PMID: 25598764)
Wien Klin Wochenschr. 2021 May;133(9-10):484-491. (PMID: 33211152)
J Ovarian Res. 2019 Jun 15;12(1):55. (PMID: 31202269)
Trends Mol Med. 2010 May;16(5):238-46. (PMID: 20444648)
N Engl J Med. 2023 Mar 2;388(9):804-812. (PMID: 36856616)
Mol Metab. 2021 Jul;49:101195. (PMID: 33609766)
Exp Gerontol. 2006 Dec;41(12):1243-6. (PMID: 17071038)
Antioxid Redox Signal. 2019 Jan 10;30(2):251-294. (PMID: 29634344)
Int J Mol Sci. 2017 Aug 28;18(9):. (PMID: 28846632)
Nat Rev Rheumatol. 2023 Apr;19(4):200-211. (PMID: 36750681)
Semin Cell Dev Biol. 2024 Mar 15;156:107-120. (PMID: 37734998)
Aging Cell. 2007 Feb;6(1):111-9. (PMID: 17266680)
Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2120887119. (PMID: 35580182)
Genome Med. 2019 Aug 23;11(1):54. (PMID: 31443728)
Exp Gerontol. 2001 Feb;36(2):341-52. (PMID: 11226747)
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14164-9. (PMID: 20660724)
Front Aging. 2022 May 27;3:828239. (PMID: 35821819)
Annu Rev Biochem. 2010;79:683-706. (PMID: 20350166)
Aging Cell. 2013 Jun;12(3):478-88. (PMID: 23521856)
Genome Biol. 2013;14(10):R115. (PMID: 24138928)
Invest Ophthalmol Vis Sci. 2018 Oct 1;59(12):4978-4985. (PMID: 30326066)
Nat Aging. 2021 Aug;1(8):634-650. (PMID: 34901876)
Cell. 2013 Dec 19;155(7):1624-38. (PMID: 24360282)
Physiol Rep. 2016 Jun;4(11):. (PMID: 27252251)
Annu Rev Nutr. 2020 Sep 23;40:105-133. (PMID: 32559388)
J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):667-74. (PMID: 23213031)
Oxid Med Cell Longev. 2017;2017:5716409. (PMID: 28894508)
Anal Biochem. 1973 Jun;53(2):452-8. (PMID: 4351948)
J Clin Invest. 2015 Jan;125(1):85-93. (PMID: 25654554)
FEBS J. 2022 Jan;289(1):75-89. (PMID: 33730405)
Biogerontology. 2014 Apr;15(2):177-98. (PMID: 24337988)
FEBS J. 2022 Mar;289(6):1650-1667. (PMID: 34689411)
PLoS Genet. 2017 Jan 27;13(1):e1006565. (PMID: 28129359)
Aging Cell. 2023 Dec;22(12):e14006. (PMID: 37803875)
JAMA Netw Open. 2022 May 2;5(5):e2213875. (PMID: 35616942)
JCI Insight. 2020 Jun 18;5(12):. (PMID: 32554926)
Nat Rev Mol Cell Biol. 2021 Feb;22(2):75-95. (PMID: 33328614)
Rapid Commun Mass Spectrom. 1992 Jul;6(7):421-4. (PMID: 1638043)
Mol Cancer. 2019 Jan 24;18(1):17. (PMID: 30678689)
Exp Gerontol. 2008 Sep;43(9):813-9. (PMID: 18662766)
Metabolites. 2021 Jan 14;11(1):. (PMID: 33466750)
Mol Syst Biol. 2011 Aug 30;7:525. (PMID: 21878913)
Prog Neurobiol. 2021 Apr;199:101953. (PMID: 33188884)
Sci Rep. 2018 Mar 26;8(1):5210. (PMID: 29581467)
J Biol Chem. 2018 Apr 13;293(15):5414-5424. (PMID: 29247007)
Neurochem Int. 2017 Oct;109:202-209. (PMID: 28235551)
Nat Aging. 2024 Feb;4(2):231-246. (PMID: 38243142)
Cell. 2023 Aug 31;186(18):3758-3775. (PMID: 37657418)
Clin Chim Acta. 2020 Jul;506:72-83. (PMID: 32092316)
Int J Mol Sci. 2021 Jul 29;22(15):. (PMID: 34360912)
Nutrients. 2020 Dec 07;12(12):. (PMID: 33297486)
Nat Rev Endocrinol. 2022 Apr;18(4):243-258. (PMID: 35145250)
FEBS Lett. 2017 Sep;591(17):2648-2660. (PMID: 28696498)
Sci Transl Med. 2014 Dec 24;6(268):268ra179. (PMID: 25540326)
Nat Rev Mol Cell Biol. 2021 Feb;22(2):119-141. (PMID: 33353981)
Exp Cell Res. 1961 Dec;25:585-621. (PMID: 13905658)
Metabolites. 2019 Dec 13;9(12):. (PMID: 31847272)
Microbiol Immunol. 2011 Jan;55(1):1-11. (PMID: 21175768)
Exp Gerontol. 2021 Dec;156:111598. (PMID: 34695518)
Cell Metab. 2020 Jun 2;31(6):1078-1090.e5. (PMID: 32386566)
Ann N Y Acad Sci. 2006 May;1067:10-21. (PMID: 16803965)
Elife. 2018 Nov 14;7:. (PMID: 30427307)
Biogerontology. 2008 Apr;9(2):67-84. (PMID: 18175203)
Cell Metab. 2016 Jun 14;23(6):1060-1065. (PMID: 27304507)
Nat Commun. 2021 Oct 26;12(1):6173. (PMID: 34702852)
Biomedicines. 2020 Jul 07;8(7):. (PMID: 32645916)
Biotechnol Adv. 2013 Sep-Oct;31(5):563-92. (PMID: 23022622)
Nat Cell Biol. 2013 Aug;15(8):978-90. (PMID: 23770676)
Exp Gerontol. 2016 Oct;83:130-8. (PMID: 27498120)
Mutat Res. 1992 Sep;275(3-6):169-80. (PMID: 1383759)
Elife. 2020 Jun 09;9:. (PMID: 32515735)
Aging Cell. 2024 Mar;23(3):e14060. (PMID: 38062873)
Psychopharmacology (Berl). 1985;87(4):390-5. (PMID: 3936095)
Metabolites. 2022 Jul 09;12(7):. (PMID: 35888754)
Mutat Res. 1992 Sep;275(3-6):257-66. (PMID: 1383768)
Nat Rev Mol Cell Biol. 2023 Mar;24(3):186-203. (PMID: 36097284)
Cell Rep. 2021 Jan 19;34(3):108660. (PMID: 33472069) - Grant Information: NUHSRO/2022/047/Startup/11 National University of Singapore; Vidi grant from the Netherlands Organization for Scientific Research (NWO; 09150172110059) Amsterdam UMC/University of Amsterdam
- Contributed Indexing: Keywords: aging; biological clocks; biomarkers; clinical trials; drug development; geroprotector; healthy longevity; machine learning; omics; supplements
- الرقم المعرف: 0 (Biomarkers)
- الموضوع: Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629
- الموضوع: 20240629
- الرقم المعرف: PMC11203944
- الرقم المعرف: 10.3390/ijms25126793
- الرقم المعرف: 38928497
- المصدر:
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