Interactions of Serum Amyloid A Proteins with the Blood-Brain Barrier: Implications for Central Nervous System Disease.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Blood-Brain Barrier*/metabolism ; Serum Amyloid A Protein*/metabolism; Humans ; Animals ; Central Nervous System Diseases/metabolism

Serum amyloid A (SAA) proteins are highly conserved lipoproteins that are notoriously involved in the acute phase response and systemic amyloidosis, but their biological functions are incompletely understood. Recent work has shown that SAA proteins can enter the brain by crossing the intact blood-brain barrier (BBB), and that they can impair BBB functions. Once in the central nervous system (CNS), SAA proteins can have both protective and harmful effects, which have important implications for CNS disease. In this review of the thematic series on SAA, we discuss the existing literature that relates SAA to neuroinflammation and CNS disease, and the possible roles of the BBB in these relations.

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Keywords: Alzheimer’s disease; amyloidosis; blood–brain barrier; lipoproteins; neuroinflammation; serum amyloid A

0 (Serum Amyloid A Protein)

Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629

20240629

PMC11204325

10.3390/ijms25126607

38928312