Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
Exosomes Derived from Adipose Mesenchymal Stem Cells Promote Regeneration of Injured Liver in Minipigs.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
- معلومة اضافية
- المصدر:
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
- بيانات النشر:
Original Publication: Basel, Switzerland : MDPI, [2000-
- الموضوع:
- نبذة مختصرة :
Hepatic ischemia/reperfusion injury (IRI) is an important factor affecting liver regeneration and functional recovery postoperatively. Many studies have suggested that mesenchymal stem cells (MSCs) contribute to hepatic tissue repair and functional recovery through paracrine mechanisms mediated by exosomes. Minipigs exhibit much more similar characteristics of the liver to those of humans than rodents. This study aimed to explore whether exosomes from adipose-derived MSCs (ADSCs-exo) could actively promote liver regeneration after hepatectomy combined with HIRI in minipigs and the role they play in the cell proliferation process. This study also compared the effects and differences in the role of ADSCs and ADSCs-exo in the inflammatory response and liver regeneration. The results showed that ADSCs-exo suppressed histopathological changes and reduced inflammatory infiltration in the liver; significantly decreased levels of ALT, TBIL, HA, and the pro-inflammatory cytokines TNF-α, IL-6, and CRP; increased levels of the anti-inflammatory cytokine IL-10 and the pro-regeneration factors Ki67, PCNA, CyclinD1, HGF, STAT3, VEGF, ANG1, ANG2; and decreased levels of the anti-regeneration factors SOCS3 and TGF-β. These indicators above showed similar changes with the ADSCs intervention group. Indicating that ADSCs-exo can exert the same role as ADSCs in regulating inflammatory responses and promoting liver regeneration. Our findings provide experimental evidence for the possibility that ADSCs-exo could be considered a safe and effective cell-free therapy to promote regeneration of injured livers.
- References:
J Hepatobiliary Pancreat Surg. 2003;10(3):195-9. (PMID: 14605975)
Front Pharmacol. 2023 Jan 10;13:1078761. (PMID: 36703756)
Front Bioeng Biotechnol. 2023 Feb 21;11:1098172. (PMID: 36896013)
Stem Cells Dev. 2019 Nov 1;28(21):1451-1462. (PMID: 31495270)
Hepatology. 1999 Mar;29(3):809-13. (PMID: 10051483)
Cytokine. 2019 Sep;121:154733. (PMID: 31154249)
Cardiovasc Res. 2019 Jun 1;115(7):1205-1216. (PMID: 30753344)
Hepatol Int. 2015 Apr;9(2):310-20. (PMID: 25788187)
J Cell Physiol. 2018 Apr;233(4):2889-2901. (PMID: 28543438)
Bioact Mater. 2023 Mar 29;27:98-112. (PMID: 37006826)
Front Cell Dev Biol. 2023 Apr 04;11:1171317. (PMID: 37082623)
Stem Cell Res Ther. 2021 Mar 30;12(1):218. (PMID: 33781342)
Am J Pathol. 2011 Apr;178(4):1614-21. (PMID: 21435447)
Cell Mol Biol Lett. 2014 Jun;19(2):181-200. (PMID: 24643584)
Circ Res. 2017 Aug 4;121(4):411-423. (PMID: 28642329)
Oxid Med Cell Longev. 2014;2014:906965. (PMID: 24799983)
PLoS One. 2017 Mar 23;12(3):e0174303. (PMID: 28333993)
Front Immunol. 2021 Dec 14;12:803037. (PMID: 34970275)
Dig Surg. 2007;24(4):274-81. (PMID: 17657152)
Cells. 2023 Feb 13;12(4):. (PMID: 36831271)
Int J Mol Sci. 2022 Oct 11;23(20):. (PMID: 36292924)
Life Sci. 2023 May 15;321:121618. (PMID: 36966916)
Cell Mol Gastroenterol Hepatol. 2023;15(6):1463-1474. (PMID: 36940849)
FASEB J. 2022 Oct;36(10):e22553. (PMID: 36111980)
Science. 2003 Feb 7;299(5608):890-3. (PMID: 12574630)
J Extracell Vesicles. 2020 Dec;10(2):e12030. (PMID: 33335695)
J Cell Physiol. 2020 Apr;235(4):3698-3710. (PMID: 31566731)
Biol Cell. 2005 Apr;97(4):277-88. (PMID: 15762849)
Stem Cell Res Ther. 2018 Feb 06;9(1):31. (PMID: 29409540)
Stem Cell Res Ther. 2021 May 29;12(1):312. (PMID: 34051870)
Free Radic Res Commun. 1991;15(5):277-84. (PMID: 1666625)
Circ Res. 1998 Aug 10;83(3):233-40. (PMID: 9710115)
PLoS One. 2014 Sep 08;9(9):e107001. (PMID: 25198551)
J Histochem Cytochem. 2003 Dec;51(12):1681-8. (PMID: 14623936)
Int J Mol Sci. 2020 Jan 25;21(3):. (PMID: 31991836)
Liver Int. 2019 May;39(5):788-801. (PMID: 30843314)
J Cell Mol Med. 2018 Sep;22(9):4449-4459. (PMID: 29993184)
Liver Int. 2008 Jan;28(1):3-11. (PMID: 18028319)
Stem Cells Transl Med. 2014 Dec;3(12):1514-25. (PMID: 25313202)
J Cell Physiol. 2007 Nov;213(2):341-7. (PMID: 17620285)
J Biomed Opt. 2011 Nov;16(11):116011. (PMID: 22112116)
Science. 2020 Feb 7;367(6478):. (PMID: 32029601)
J Cell Physiol. 2007 Nov;213(2):286-300. (PMID: 17559071)
Hepatology. 1997 Dec;26(6):1513-20. (PMID: 9397992)
Langenbecks Arch Surg. 2012 Apr;397(4):579-90. (PMID: 22311102)
Hepatobiliary Pancreat Dis Int. 2023 Feb;22(1):22-27. (PMID: 36182636)
Front Immunol. 2022 Sep 20;13:940093. (PMID: 36203611)
Front Pharmacol. 2022 Mar 17;13:808855. (PMID: 35370682)
Front Pharmacol. 2023 May 25;14:1168545. (PMID: 37305542)
Stem Cell Res Ther. 2017 Jan 23;8(1):9. (PMID: 28115012)
Hepatology. 2010 Apr;51(4):1373-82. (PMID: 20131405)
EBioMedicine. 2018 Aug;34:231-242. (PMID: 30077720)
Stem Cell Res Ther. 2014 Jun 10;5(3):76. (PMID: 24915963)
Sci Transl Med. 2019 Oct 30;11(516):. (PMID: 31666403)
Sci Rep. 2016 Oct 27;6:36120. (PMID: 27786293)
Tissue Eng Regen Med. 2020 Aug;17(4):537-552. (PMID: 32506351)
Expert Rev Gastroenterol Hepatol. 2011 Feb;5(1):105-21. (PMID: 21309676)
Stem Cell Res Ther. 2019 Mar 18;10(1):98. (PMID: 30885249)
Int J Mol Sci. 2017 Aug 25;18(9):. (PMID: 28841158)
Stem Cells Transl Med. 2016 Dec;5(12):1620-1630. (PMID: 27460850)
J Hepatobiliary Pancreat Surg. 1999;6(3):275-80. (PMID: 10526063)
Eur J Trauma Emerg Surg. 2007 Dec;33(6):600-12. (PMID: 26815087)
Hepatology. 2003 Apr;37(4):824-32. (PMID: 12668975)
- Grant Information:
31972757 National Natural Science Foundation of China
- Contributed Indexing:
Keywords: exosomes; hepatectomy; ischemia reperfusion; liver regeneration; mesenchymal stem cells; minipig
- الرقم المعرف:
0 (Cytokines)
- الموضوع:
Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629
- الموضوع:
20240629
- الرقم المعرف:
PMC11203699
- الرقم المعرف:
10.3390/ijms25126604
- الرقم المعرف:
38928308
No Comments.