3,5-DCQA as a Major Molecule in MeJA-Treated Dendropanax morbifera Adventitious Root to Promote Anti-Lung Cancer and Anti-Inflammatory Activities.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, 2011-

Cyclopentanes*/pharmacology ; Oxylipins*/pharmacology ; Acetates*/pharmacology ; Acetates*/chemistry ; Anti-Inflammatory Agents*/pharmacology ; Anti-Inflammatory Agents*/chemistry ; Lung Neoplasms*/metabolism ; Lung Neoplasms*/drug therapy ; Lung Neoplasms*/pathology ; Plant Roots*/drug effects; Animals ; Mice ; Humans ; RAW 264.7 Cells ; Reactive Oxygen Species/metabolism ; Nitric Oxide/metabolism ; Apoptosis/drug effects ; Quinic Acid/analogs & derivatives ; Quinic Acid/pharmacology ; Quinic Acid/chemistry ; A549 Cells ; Sapindaceae/chemistry

(1) Background: Phytochemicals are crucial antioxidants that play a significant role in preventing cancer. (2) Methods: We explored the use of methyl jasmonate (MeJA) in the in vitro cultivation of D. morbifera adventitious roots (DMAR) and evaluated its impact on secondary metabolite production in DMAR, optimizing concentration and exposure time for cost-effectiveness. We also assessed its anti-inflammatory and anti-lung cancer activities and related gene expression levels. (3) Results: MeJA treatment significantly increased the production of the phenolic compound 3,5-Di-caffeoylquinic acid (3,5-DCQA). The maximum 3,5-DCQA production was achieved with a MeJA treatment at 40 µM for 36 h. MeJA-DMARE displayed exceptional anti-inflammatory activity by inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS-induced RAW 264.7 cells. Moreover, it downregulated the mRNA expression of key inflammation-related cytokines. Additionally, MeJA-DMARE exhibited anti-lung cancer activity by promoting ROS production in A549 lung cancer cells and inhibiting its migration. It also modulated apoptosis in lung cancer cells via the Bcl-2 and p38 MAPK pathways. (4) Conclusions: MeJA-treated DMARE with increased 3,5-DCQA production holds significant promise as a sustainable and novel material for pharmaceutical applications thanks to its potent antioxidant, anti-inflammatory, and anti-lung cancer properties.

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32071509 National Natural Science Foundation of China

Keywords: 3,5-Di-caffeoylquinic acid; D. morbifera; adventitious root; anti-inflammation; anti-lung cancer; methyl jasmonate

0 (Cyclopentanes)
0 (Oxylipins)
900N171A0F (methyl jasmonate)
0 (Acetates)
0 (Anti-Inflammatory Agents)
0 (Reactive Oxygen Species)
31C4KY9ESH (Nitric Oxide)
058C04BGYI (Quinic Acid)

Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629

20240629

PMC11201925

10.3390/biom14060705

38927108