Application of Biosensors for the Detection of Mycotoxins for the Improvement of Food Safety.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE

Original Publication: Basel : MDPI

Mycotoxins*/analysis ; Biosensing Techniques*/methods ; Food Safety* ; Food Contamination*/analysis; Food Microbiology/methods ; Humans ; Animals

Mycotoxins, secondary metabolites synthesized by various filamentous fungi genera such as Aspergillus , Penicillium , Fusarium , Claviceps , and Alternaria , are potent toxic compounds. Their production is contingent upon specific environmental conditions during fungal growth. Arising as byproducts of fungal metabolic processes, mycotoxins exhibit significant toxicity, posing risks of acute or chronic health complications. Recognized as highly hazardous food contaminants, mycotoxins present a pervasive threat throughout the agricultural and food processing continuum, from plant cultivation to post-harvest stages. The imperative to adhere to principles of good agricultural and industrial practice is underscored to mitigate the risk of mycotoxin contamination in food production. In the domain of food safety, the rapid and efficient detection of mycotoxins holds paramount significance. This paper delineates conventional and commercial methodologies for mycotoxin detection in ensuring food safety, encompassing techniques like liquid chromatography, immunoassays, and test strips, with a significant emphasis on the role of electrochemiluminescence (ECL) biosensors, which are known for their high sensitivity and specificity. These are categorized into antibody-, and aptamer-based, as well as molecular imprinting methods. This paper examines the latest advancements in biosensors for mycotoxin testing, with a particular focus on their amplification strategies and operating mechanisms.
Competing Interests: The authors declare no conflicts of interest.

Anal Sci. 2022 Dec;38(12):1457-1487. (PMID: 36198988)
Toxins (Basel). 2018 Feb 02;10(2):. (PMID: 29393905)
Chemosphere. 2022 Jan;287(Pt 1):131994. (PMID: 34478969)
Toxins (Basel). 2016 Apr 15;8(4):111. (PMID: 27092524)
Talanta. 2019 May 1;196:600-607. (PMID: 30683411)
Anal Chim Acta. 2014 Feb 6;811:70-5. (PMID: 24456596)
Toxins (Basel). 2022 Jun 02;14(6):. (PMID: 35737047)
J Food Drug Anal. 2015 Sep;23(3):509-515. (PMID: 28911710)
ACS Omega. 2021 Oct 28;6(44):30148-30156. (PMID: 34778686)
Biosens Bioelectron. 2017 Apr 15;90:363-377. (PMID: 27940240)
Toxins (Basel). 2020 Jul 19;12(7):. (PMID: 32707728)
Toxins (Basel). 2016 Mar 21;8(3):. (PMID: 27007394)
Biosens Bioelectron. 2017 Oct 15;96:55-61. (PMID: 28460332)
Food Chem Toxicol. 2014 Sep;71:122-7. (PMID: 24949943)
Anal Chim Acta. 2009 Jan 26;632(2):168-80. (PMID: 19110091)
Food Chem. 2015 Sep 1;182:143-9. (PMID: 25842320)
Biosens Bioelectron. 2015 Aug 15;70:268-74. (PMID: 25835519)
Trends Biotechnol. 2016 Jan;34(1):7-25. (PMID: 26506111)
Microorganisms. 2024 Jan 15;12(1):. (PMID: 38257999)
3 Biotech. 2016 Dec;6(2):159. (PMID: 28330231)
Int J Environ Res Public Health. 2017 Jun 13;14(6):. (PMID: 28608841)
Toxins (Basel). 2023 Mar 10;15(3):. (PMID: 36977106)
Trends Biotechnol. 2018 Jan;36(1):15-29. (PMID: 29102240)
Foods. 2024 Jan 11;13(2):. (PMID: 38254535)
Toxicol Lett. 2015 Feb 3;232(3):573-9. (PMID: 25542145)
Toxins (Basel). 2016 Aug 12;8(8):. (PMID: 27529281)
Toxins (Basel). 2013 Oct 11;5(10):1742-66. (PMID: 24152986)
Food Chem Toxicol. 2023 Jun;176:113756. (PMID: 36997055)
Molecules. 2021 Jun 29;26(13):. (PMID: 34210086)
Trends Biotechnol. 2019 Aug;37(8):898-915. (PMID: 30777309)
Foods. 2020 Dec 23;10(1):. (PMID: 33374559)
J Mater Chem B. 2019 Nov 14;7(42):6469-6475. (PMID: 31595937)
Res Pharm Sci. 2021 Mar 05;16(2):182-192. (PMID: 34084205)
Food Chem. 2014 Mar 1;146:212-9. (PMID: 24176334)
Essays Biochem. 2016 Jun 30;60(1):111-20. (PMID: 27365041)
Molecules. 2021 Aug 29;26(17):. (PMID: 34500671)
Chem Soc Rev. 2015 Jul 7;44(13):4185-91. (PMID: 25286013)
Food Res Int. 2021 Mar;141:110075. (PMID: 33641962)
Acta Vet Hung. 2016 Sep;64(3):390-400. (PMID: 27653435)
Int J Mol Sci. 2020 Oct 31;21(21):. (PMID: 33142955)
J Vet Res. 2021 Mar 09;65(1):87-92. (PMID: 33817400)
Food Chem. 2023 Jun 1;410:135325. (PMID: 36610091)
Food Chem. 2023 Mar 15;404(Pt A):134183. (PMID: 36240563)
J Lab Autom. 2015 Aug;20(4):365-89. (PMID: 25878051)
Chemistry. 2017 Feb 3;23(8):1853-1859. (PMID: 27933682)
Toxins (Basel). 2015 Oct 22;7(10):4253-82. (PMID: 26506387)
Toxins (Basel). 2023 Aug 19;15(8):. (PMID: 37624268)
Biosens Bioelectron. 2016 May 15;79:561-7. (PMID: 26749097)
Int J Environ Res Public Health. 2020 Jan 08;17(2):. (PMID: 31936320)
Toxicol Lett. 2020 Jun 15;326:52-60. (PMID: 32119988)
Sci Rep. 2022 Aug 25;12(1):14471. (PMID: 36008536)
Environ Pollut. 2023 Mar 1;320:121065. (PMID: 36639041)
Anal Chim Acta. 2021 Jan 2;1141:83-90. (PMID: 33248665)
J Oral Biol Craniofac Res. 2016 May-Aug;6(2):153-9. (PMID: 27195214)
Molecules. 2021 Nov 14;26(22):. (PMID: 34833960)
Toxicol Lett. 2016 Jul 8;254:1-7. (PMID: 27084041)
Toxins (Basel). 2019 Oct 25;11(11):. (PMID: 31731462)
Biosens Bioelectron. 2016 Nov 15;85:358-362. (PMID: 27196253)
Foods. 2020 May 20;9(5):. (PMID: 32443841)
Curr Protoc Nucleic Acid Chem. 2008 Sep;Appendix:3D. (PMID: 18819080)
Mol Nutr Food Res. 2005 Apr;49(4):329-36. (PMID: 15744717)
Molecules. 2023 Sep 14;28(18):. (PMID: 37764392)
Int J Food Microbiol. 2003 Nov 15;88(1):69-77. (PMID: 14527787)
Biosensors (Basel). 2020 May 30;10(6):. (PMID: 32486225)
Food Chem. 2018 Apr 15;245:189-195. (PMID: 29287360)
Biosensors (Basel). 2012 Jul 24;2(3):269-72. (PMID: 25585929)
Foods. 2021 Sep 13;10(9):. (PMID: 34574279)
Res Pharm Sci. 2022 Oct 29;17(6):677-685. (PMID: 36704432)
Foods. 2020 Mar 05;9(3):. (PMID: 32150943)
Food Chem. 2019 Jun 1;282:141-146. (PMID: 30711098)
ACS Omega. 2020 Jul 14;5(29):17876-17882. (PMID: 32743158)
Food Chem. 2022 Oct 1;390:133200. (PMID: 35580516)
Foods. 2023 Feb 06;12(4):. (PMID: 36832782)
Molecules. 2021 May 15;26(10):. (PMID: 34063344)
Environ Health Perspect. 2017 Sep 11;125(9):095001. (PMID: 28893723)
Methods Mol Biol. 2007;385:103-20. (PMID: 18365707)
Microb Pathog. 2020 Feb 22;142:104095. (PMID: 32097745)
Anal Chem. 2020 Jun 16;92(12):8422-8426. (PMID: 32403920)
Food Chem. 2023 May 1;407:135113. (PMID: 36493484)
Biosens Bioelectron. 2022 Nov 15;216:114664. (PMID: 36057240)
Biosens Bioelectron. 2023 Feb 15;222:114991. (PMID: 36495721)
Food Chem. 2023 Jan 15;399:134002. (PMID: 36037690)
Life (Basel). 2023 Mar 26;13(4):. (PMID: 37109409)
Anal Chem. 2019 Mar 5;91(5):3546-3554. (PMID: 30724076)
Mikrochim Acta. 2019 Nov 6;186(12):748. (PMID: 31696359)
Toxins (Basel). 2021 Aug 16;13(8):. (PMID: 34437443)

Keywords: biosensors; detection; food management; mycotoxins

0 (Mycotoxins)

Date Created: 20240626 Date Completed: 20240626 Latest Revision: 20240629

20240629

PMC11209361

10.3390/toxins16060249

38922144