Synthesis, characterization and biological applications of substituted indolo[2,1-b]quinazolin-12(6H)-one based rhenium(I) organometallic compounds.

Publisher: Slovenian Chemical Society Country of Publication: Slovenia NLM ID: 101247110 Publication Model: Electronic Cited Medium: Internet ISSN: 1580-3155 (Electronic) Linking ISSN: 13180207 NLM ISO Abbreviation: Acta Chim Slov Subsets: MEDLINE

Original Publication: Ljubljana : Slovenian Chemical Society,

Rhenium*/chemistry ; Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/chemical synthesis; Humans ; MCF-7 Cells ; Cell Proliferation/drug effects ; Organometallic Compounds/pharmacology ; Organometallic Compounds/chemical synthesis ; Organometallic Compounds/chemistry ; Molecular Docking Simulation ; DNA/metabolism ; Coordination Complexes/pharmacology ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Drug Screening Assays, Antitumor ; Density Functional Theory ; Cattle ; Quinazolinones/chemical synthesis ; Quinazolinones/pharmacology ; Quinazolinones/chemistry ; Molecular Structure ; Animals ; Indoles/pharmacology ; Indoles/chemistry ; Indoles/chemical synthesis

The Re(I) organometallic compounds [(Re(CO)3L1-6 )Cl], where Ligand(L) = Tryptanthrin derivatives were prepared and characterized by various spectroscopic techniques. To assess the binding capacities and binding manner, tests of Calf thymus DNA under the impact of organometallic complexes were conducted using absorption titration and viscosity measuring techniques. Data from the research mentioned above point to an intercalation type of binding, which was verified by the docking study. Swiss ADME tools carried out an ADME study. The work focuses on computing the molecular orbital energies for the synthesized compounds using the density functional theory (DFT). The compounds were tested against the MCF-7 cell line to determine their anticancer effects. It was observed that their IC50 values were equivalent to those of the standard medication, indicating that they had a similar antiproliferative impact.

7440-15-5 (Rhenium)
0 (Antineoplastic Agents)
91080-16-9 (calf thymus DNA)
0 (Organometallic Compounds)
9007-49-2 (DNA)
0 (Coordination Complexes)
0 (Quinazolinones)
0 (Indoles)

Date Created: 20240626 Date Completed: 20240626 Latest Revision: 20240708

20240708

10.17344/acsi.2023.8579

38919105