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Genetic variation of TLR3 gene is associated with the outcome of hepatitis b infection in mauritanian patients: case control study.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : BioMed Central, [2001-
    • الموضوع:
      Toll-Like Receptor 3*/genetics ; Polymorphism, Single Nucleotide* ; Hepatitis B, Chronic*/genetics ; Hepatitis B, Chronic*/virology ; Genetic Predisposition to Disease*; Humans ; Male ; Female ; Case-Control Studies ; Adult ; Middle Aged ; Mauritania ; Young Adult ; Hepatitis B virus/genetics
    • نبذة مختصرة :
      Background: Toll-Like receptors (TLRs) play an important role in the immune response during hepatitis B virus (HBV) infection. In this study, we evaluated the association between two SNP variants (TLR3 rs3775290 and TLR4 rs4986790) and susceptibility to chronic HBV infection in Mauritania.
      Subjects and Methods: A total of 188 subjects were recruited for this study: 102 chronically infected patients and 86 individuals with spontaneously resolved HBV infection who were considered controls. Targeted PCR products were sequenced using Sanger sequencing.
      Results: We found that TLR3 rs3775290 was significantly more frequent in patients with chronic HBV than in the control population (p = 0.03). However, no association was found between the TLR4 rs3775290 polymorphism and chronic infection.
      Conclusion: Our results suggest that the TLR3 rs3775290 polymorphism may be a risk factor for susceptibility to chronic HBV infection in the Mauritanian population.
      (© 2024. The Author(s).)
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    • Contributed Indexing:
      Keywords: Chronic hepatitis B virus; Single-nucleotide polymorphism; TLR3; TLR4
    • الرقم المعرف:
      0 (Toll-Like Receptor 3)
      0 (TLR3 protein, human)
    • الموضوع:
      Date Created: 20240621 Date Completed: 20240621 Latest Revision: 20240719
    • الموضوع:
      20240719
    • الرقم المعرف:
      PMC11191147
    • الرقم المعرف:
      10.1186/s12879-024-09503-w
    • الرقم المعرف:
      38907187