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Genetic variation of TLR3 gene is associated with the outcome of hepatitis b infection in mauritanian patients: case control study.
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- معلومة اضافية
- المصدر:
Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
- بيانات النشر:
Original Publication: London : BioMed Central, [2001-
- الموضوع:
- نبذة مختصرة :
Background: Toll-Like receptors (TLRs) play an important role in the immune response during hepatitis B virus (HBV) infection. In this study, we evaluated the association between two SNP variants (TLR3 rs3775290 and TLR4 rs4986790) and susceptibility to chronic HBV infection in Mauritania.
Subjects and Methods: A total of 188 subjects were recruited for this study: 102 chronically infected patients and 86 individuals with spontaneously resolved HBV infection who were considered controls. Targeted PCR products were sequenced using Sanger sequencing.
Results: We found that TLR3 rs3775290 was significantly more frequent in patients with chronic HBV than in the control population (p = 0.03). However, no association was found between the TLR4 rs3775290 polymorphism and chronic infection.
Conclusion: Our results suggest that the TLR3 rs3775290 polymorphism may be a risk factor for susceptibility to chronic HBV infection in the Mauritanian population.
(© 2024. The Author(s).)
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- Contributed Indexing:
Keywords: Chronic hepatitis B virus; Single-nucleotide polymorphism; TLR3; TLR4
- الرقم المعرف:
0 (Toll-Like Receptor 3)
0 (TLR3 protein, human)
- الموضوع:
Date Created: 20240621 Date Completed: 20240621 Latest Revision: 20240719
- الموضوع:
20240719
- الرقم المعرف:
PMC11191147
- الرقم المعرف:
10.1186/s12879-024-09503-w
- الرقم المعرف:
38907187
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