Dosimetric analysis of six whole-breast irradiation techniques in supine and prone positions.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Breast Neoplasms*/radiotherapy ; Organs at Risk*/radiation effects ; Radiotherapy Dosage*; Humans ; Female ; Prone Position ; Supine Position ; Radiotherapy Planning, Computer-Assisted/methods ; Radiometry/methods ; Patient Positioning/methods ; Lung/radiation effects ; Middle Aged ; Radiotherapy, Intensity-Modulated/methods ; Radiotherapy, Intensity-Modulated/adverse effects ; Heart/radiation effects

In breast cancer radiation therapy, minimizing radiation-related risks and toxicity is vital for improving life expectancy. Tailoring radiotherapy techniques and treatment positions can reduce radiation doses to normal organs and mitigate treatment-related toxicity. This study entailed a dosimetric comparison of six different external beam whole-breast irradiation techniques in both supine and prone positions. We selected fourteen breast cancer patients, generating six treatment plans in both positions per patient. We assessed target coverage and organs at risk (OAR) doses to evaluate the impact of treatment techniques and positions. Excess absolute risk was calculated to estimate potential secondary cancer risk in the contralateral breast, ipsilateral lung, and contralateral lung. Additionally, we analyzed the distance between the target volume and OARs (heart and ipsilateral lung) while considering the treatment position. The results indicate that prone positioning lowers lung exposure in X-ray radiotherapy. However, particle beam therapies (PBTs) significantly reduce the dose to the heart and ipsilateral lung regardless of the patient's position. Notably, negligible differences were observed between arc-delivery and static-delivery PBTs in terms of target conformity and OAR sparing. This study provides critical dosimetric evidence to facilitate informed decision-making regarding treatment techniques and positions.
(© 2024. The Author(s).)

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6-2021-0234 Yonsei University College of Medicine; P0026103 Korea Institute for Advancement of Technology; RS-2022-KN071210 Nuclear Safety and Security Commission; RS-2023-00249964 Ministry of Education

Date Created: 20240621 Date Completed: 20240621 Latest Revision: 20240624

20240624

PMC11192744

10.1038/s41598-024-65461-y

38907042