Serum vitamin D, blood pressure and hypertension risk in the HUNT study using observational and Mendelian randomization approaches.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Vitamin D*/blood ; Vitamin D*/analogs & derivatives ; Mendelian Randomization Analysis* ; Hypertension*/blood ; Hypertension*/epidemiology ; Hypertension*/genetics ; Blood Pressure*; Humans ; Male ; Middle Aged ; Female ; Cross-Sectional Studies ; Norway/epidemiology ; Aged ; Prospective Studies ; Risk Factors ; Adult

Limited studies have triangulated the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and systolic blood pressure (SBP), diastolic blood pressure (DBP) or hypertension risk utilizing both observational and Mendelian randomization (MR) approaches. We employed data from the Norwegian Trøndelag Health Study (HUNT) to conduct cross-sectional (n = 5854) and prospective (n = 3592) analyses, as well as one-sample MR (n = 86,324). We also used largest publicly available data for two-sample MR. Our cross-sectional analyses showed a 25 nmol/L increase in 25(OH)D was associated with a 1.73 mmHg decrease in SBP (95% CI - 2.46 to - 1.01), a 0.91 mmHg decrease in DBP (95% CI - 1.35 to - 0.47) and 19% lower prevalence of hypertension (OR 0.81, 95% CI 0.74 to 0.90) after adjusting for important confounders. However, these associations disappeared in prospective analyses. One-sample and two-sample MR results further suggested no causal relationship between serum vitamin D levels and blood pressure or hypertension risk in the general population.
(© 2024. The Author(s).)

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project ID: 30320 Helse Midt-Norge; project ID: 2018/42794 Helse Midt-Norge; N.K.S.: 40014 Norske Kvinners Sanitetsforening

Keywords: Blood pressure; Hypertension; Mendelian randomization; Observational analyses; Serum 25-hydroxyvitamin D; The HUNT Study

1406-16-2 (Vitamin D)
A288AR3C9H (25-hydroxyvitamin D)

Date Created: 20240621 Date Completed: 20240621 Latest Revision: 20240624

20240625

PMC11192928

10.1038/s41598-024-64649-6

38906907