Ramadan intermittent fasting is associated with improved anticoagulant activity among healthy people: a case-control study.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Fasting*/blood ; Blood Coagulation*/drug effects ; Anticoagulants*/administration & dosage ; Islam*; Humans ; Male ; Adult ; Female ; Case-Control Studies ; Protein C/metabolism ; Protein S/metabolism ; Protein S/analysis ; Blood Coagulation Tests ; Healthy Volunteers ; Fibrinogen/metabolism ; Middle Aged ; Young Adult ; Prothrombin Time ; Antithrombins ; Partial Thromboplastin Time ; Intermittent Fasting

Data on the pathophysiological mechanisms of hemostatic alterations in the thrombotic events that occur during Ramadan intermittent fasting (RIF), particularly in the natural coagulation inhibitors, are very limited. Thus, our objective was to evaluate the effect of RIF on the natural anticoagulants level, antithrombin, protein C, and total and free protein S (PS) in healthy participants. Participants were divided into two groups. Group I consisted of 29 healthy fasting participants whose blood samples were taken after 20 days of fasting. Group II included 40 healthy non-fasting participants whose blood samples were taken 2-4 weeks before the month of Ramadan. Coagulation screening tests including prothrombin time (PT), activated partial thromboplastin time (APTT) and plasma fibrinogen level, natural anticoagulants; antithrombin, protein C, free and total PS and C4 binding protein (C4BP) levels were evaluated in the two groups. High levels of total and free PS without change in antithrombin, protein C, and C4BP levels were noted in the fasting group as compared with non-fasting ones (p < 0.05). PT and APTT showed no difference between the two groups. However, the fibrinogen level was higher in the fasting group. In conclusion, RIF was found to be associated with improved anticoagulant activity in healthy participants, which may provide temporal physiological protection against the development of thrombosis in healthy fasting people.
(© 2024. The Author(s).)

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0 (Anticoagulants)
0 (Protein C)
0 (Protein S)
9001-32-5 (Fibrinogen)
0 (Antithrombins)

Date Created: 20240615 Date Completed: 20240615 Latest Revision: 20240618

20240618

PMC11180170

10.1038/s41598-024-64582-8

38879576