Associations between oxidative balance score and chronic kidney disease events in US adults: a population-based study.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Renal Insufficiency, Chronic*/epidemiology ; Renal Insufficiency, Chronic*/metabolism ; Nutrition Surveys* ; Glomerular Filtration Rate*; Humans ; Male ; Female ; Adult ; Middle Aged ; Cross-Sectional Studies ; United States/epidemiology ; Prevalence ; Aged ; Oxidative Stress ; Risk Factors ; Antioxidants/metabolism ; Young Adult ; Life Style

Oxidative Balance Scores (OBS) are utilized to assess an individual's antioxidant status, encompassing both dietary and lifestyle factors that contribute to oxidative balance. This study investigates the relationship between OBS and chronic kidney disease (CKD) prevalence among U.S. adults, utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. The study involved a cross-sectional analysis of 13,373 individuals from NHANES, focusing on adults aged 20 years or older. OBS was calculated using 20 components, including dietary and lifestyle factors. CKD was identified based on albumin-to-creatinine ratio and estimated glomerular filtration rate, with patients stratified into mild, moderate, and high-risk groups. Statistical analysis included logistic regression models and restricted cubic splines to explore the OBS-CKD relationship. Our findings indicate a statistically significant negative correlation between OBS and CKD prevalence, particularly in mild and moderate-risk groups. Higher OBS quartiles were associated with a decreased likelihood of CKD (OR 0.70; 95% CI 0.53-0.92; P = 0.013). Restricted cubic splines indicated a non-linear, inverse association between OBS and CKD odds for the overall population (P for nonlinearity = 0.017). For mild and moderate CKD risk groups, the relationships were less pronounced (P for nonlinearity = 0.053 and 0.184, respectively), suggesting variability in the OBS-CKD link across different risk levels. The study highlights the potential of elevated OBS as a primary prevention measure for CKD, particularly in individuals with mild to moderate risk. These findings underscore the importance of antioxidant status in CKD risk management and encourage further research into the role of dietary and lifestyle factors in CKD prevention.
(© 2024. The Author(s).)

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Keywords: Chronic kidney disease; Cross-sectional study; National health and nutrition examination survey; Oxidative balance scores; US adults

0 (Antioxidants)

Date Created: 20240614 Date Completed: 20240615 Latest Revision: 20240618

20240618

PMC11178767

10.1038/s41598-024-64147-9

38877058