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Effect of the treatment of iron deficiency anemia on chronic drug-resistant cough: a rare case report.

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  • معلومة اضافية
    • المصدر:
      Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101125969 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2008-2231 (Electronic) Linking ISSN: 15608115 NLM ISO Abbreviation: Daru Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2018- : Cham : Springer International Publishing
      Original Publication: Tehran, Iran : The Faculty
    • الموضوع:
      Cough*/drug therapy ; Cough*/etiology ; Anemia, Iron-Deficiency*/drug therapy; Humans ; Female ; Middle Aged ; Chronic Disease ; Folic Acid/therapeutic use ; Folic Acid/administration & dosage ; Vitamin B 12/therapeutic use ; Vitamin B 12/administration & dosage ; Ascorbic Acid/therapeutic use ; Ascorbic Acid/administration & dosage ; Drug Resistance ; Iron/therapeutic use ; Treatment Outcome ; Dietary Supplements ; Ferrous Compounds/therapeutic use ; Ferrous Compounds/administration & dosage
    • نبذة مختصرة :
      Background: A persistent difficult-to-treat cough can be exhausting. Iron is an essential element that plays an important role in regulating the production of pro-inflammatory cytokines, and its deficiency may potentiate airway inflammation and dysfunction. There is a paucity of data regarding a link between iron deficiency (ID) and idiopathic cough.
      Objectives: In this study, a case of persistent non-productive cough, which was unresponsive to targeted treatment approaches but responsive to iron therapy, is reported.
      Methods: A 53-year-old woman came to a medical clinic with complaints of a chronic and progressive non-productive cough. She underwent a complete clinical and paraclinical evaluation.
      Results: Her vital signs were stable and no abnormalities were found on the physical examination. The results of the spirometry and chest radiography were unremarkable. The laboratory test indicated hypochromic microcytic anemia, with a hemoglobin value of 9.6 g/dL. Her cough was resolved after treatment of iron-deficiency anemia with an oral nutraceutical capsule containing 28 mg of elemental iron (as ferrous bis-glycinate) plus folic acid, vitamin B12, and vitamin C, once daily for six months.
      Conclusion: In the case of unexplained chronic cough, resistant to targeted therapies, investigation and treatment of ID may contribute to the resolution of cough.
      Competing Interests: Declarations Conflicts of Interest The authors declare that they have no conflict of interest.
      (© 2024. The Author(s), under exclusive licence to Tehran University of Medical Sciences.)
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    • Contributed Indexing:
      Keywords: Cough; Drug resistance; Iron deficiency; Therapy
    • الرقم المعرف:
      935E97BOY8 (Folic Acid)
      P6YC3EG204 (Vitamin B 12)
      PQ6CK8PD0R (Ascorbic Acid)
      E1UOL152H7 (Iron)
      0 (Ferrous Compounds)
    • الموضوع:
      Date Created: 20240608 Date Completed: 20241111 Latest Revision: 20241114
    • الموضوع:
      20241114
    • الرقم المعرف:
      PMC11554957
    • الرقم المعرف:
      10.1007/s40199-024-00522-1
    • الرقم المعرف:
      38850453