Heteroatom-doped carbon dots from medicinal plants as novel biomaterials for as-use biomedical applications in comparison with synthetic drug, zaltoprofen.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Carbon*/chemistry ; Biocompatible Materials*/chemistry ; Biocompatible Materials*/pharmacology ; Plants, Medicinal*/chemistry; Quantum Dots/chemistry ; Plant Leaves/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Microbial Sensitivity Tests ; Humans ; Spectroscopy, Fourier Transform Infrared ; Antioxidants/pharmacology ; Antioxidants/chemistry

FN-doped carbon dots were synthesized using powdered leaves of Moringa oleifera L./Chromolaena odorata L./Tridax procumbens L./Tinospora cordifolia L./ and Lantana camara L., along with a precursor called 4,5-difluoro-1,2-benzenediamine (DFBD) and compared against the drug zaltoprofen derived carbon dots. They were assessed for their optical and structural characteristics using photoluminescence (optimal emission λ of 600 nm), vibrational (FTIR) spectroscopy (characteristic wave numbers of 1156 and 1269 cm ^-1 for C-F), as well as X-ray diffraction (XRD) (highest intensity at 27.56°) and high-resolution transmission electron microscopy (HR-TEM) (particles in the size range of 15-20 nm). Further, field emission scanning electron microscopy (FESEM) / energy dispersive spectroscopy (EDX) indicated FN doping of oval/oblong carbon dots. Membrane protection in percent is found to be 55.3 and 80.4 for FN-CDs and Z-FN-CDs respectively. The DPPH-free radical scavenging activity by FN-CDs was 69.4%, while with Z-FN-CDs, it was 54.2%. When tested on six bacterial strains (three each for gram-positive and gram-negative), the FN-CDs displayed a halo (ZOI) between 9 and 19 mm, whereas the Z-FN-CDs displayed a clearance zone between 9 and 17 mm. The FN-CDs showed significant emission-red-shift effects and demonstrated concentration-dependent biocompatibility and viability in neuroblastoma and beta-TC6-cell lines.
(© 2024. The Author(s).)

Science. 1994 Oct 7;266(5182):72-5. (PMID: 17814001)
Chem Commun (Camb). 2018 May 24;54(43):5401-5406. (PMID: 29736525)
ACS Nano. 2017 Jul 25;11(7):6703-6716. (PMID: 28677399)
J Am Chem Soc. 2004 Oct 13;126(40):12736-7. (PMID: 15469243)
Int J Pharm. 2019 Jun 10;564:308-317. (PMID: 31015004)
Int J Cosmet Sci. 2023 Jun;45(3):299-314. (PMID: 36794452)
Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):68-76. (PMID: 31852285)
J Fluoresc. 2019 Sep;29(5):1133-1141. (PMID: 31399831)
Angew Chem Int Ed Engl. 2015 Apr 27;54(18):5360-3. (PMID: 25832292)
J Anal Methods Chem. 2023 Apr 25;2023:7515979. (PMID: 37144174)
Plants (Basel). 2023 Dec 20;13(1):. (PMID: 38202328)
J Biomed Res. 2011 Jan;25(1):56-62. (PMID: 23554672)
ACS Omega. 2021 Aug 27;6(36):23475-23484. (PMID: 34549145)
Nanoscale. 2014 May 7;6(9):4676-82. (PMID: 24647626)
J Food Drug Anal. 2023 Jun 15;31(2):244-253. (PMID: 37335167)
J Hazard Mater. 2021 Mar 15;406:124330. (PMID: 33144016)
Luminescence. 2020 Mar;35(2):196-202. (PMID: 31591819)
Antioxidants (Basel). 2020 Mar 25;9(4):. (PMID: 32218135)
Discov Nano. 2023 Mar 2;18(1):30. (PMID: 36862234)
J Photochem Photobiol B. 2019 Jan;190:8-20. (PMID: 30453162)
Biol Res. 2007;40(1):13-21. (PMID: 17657351)
Langmuir. 2019 May 28;35(21):6939-6949. (PMID: 31050292)
Oxid Med Cell Longev. 2023 May 25;2023:3076119. (PMID: 37273553)
ACS Appl Mater Interfaces. 2016 May 4;8(17):10717-25. (PMID: 27014959)
RSC Adv. 2018 Feb 7;8(11):6053-6062. (PMID: 35539571)
ACS Appl Bio Mater. 2020 Jan 21;3(1):358-368. (PMID: 35019452)
Sci Rep. 2023 Jun 15;13(1):9676. (PMID: 37322059)
Nanomaterials (Basel). 2020 Nov 23;10(11):. (PMID: 33238367)
Nature. 2002 Sep 26;419(6905):384-7. (PMID: 12352988)
Small. 2019 May;15(22):e1900322. (PMID: 31021489)
Adv Healthc Mater. 2016 Oct;5(19):2545-2554. (PMID: 27448287)
ACS Nano. 2013 Aug 27;7(8):6434-64. (PMID: 23808482)
Sci Rep. 2023 Apr 4;13(1):5502. (PMID: 37015951)
Front Chem. 2019 Oct 04;7:671. (PMID: 31637234)
ACS Biomater Sci Eng. 2023 Mar 13;9(3):1307-1319. (PMID: 36744996)
Materials (Basel). 2023 Aug 24;16(17):. (PMID: 37687493)
Chemosphere. 2023 Feb;313:137444. (PMID: 36462566)
Spectrochim Acta A Mol Biomol Spectrosc. 2023 Jul 5;295:122616. (PMID: 36947938)
J Fluoresc. 2023 Jul;33(4):1619-1629. (PMID: 36800043)
Sci Rep. 2023 Apr 19;13(1):6371. (PMID: 37076562)
Artif Cells Nanomed Biotechnol. 2021 Dec;49(1):11-19. (PMID: 33331196)
RSC Adv. 2023 Jul 12;13(30):21088-21095. (PMID: 37448635)
Biomaterials. 2010 Mar;31(9):2673-85. (PMID: 20034666)
J Colloid Interface Sci. 2022 Apr;611:545-553. (PMID: 34971965)
ACS Omega. 2020 Nov 19;5(47):30363-30372. (PMID: 33283084)
Chem Soc Rev. 2008 Feb;37(2):320-30. (PMID: 18197348)
Angew Chem Int Ed Engl. 2020 Jun 15;59(25):9986-9991. (PMID: 31743553)
J Mater Chem B. 2020 Apr 1;8(13):2598-2606. (PMID: 32124889)
Inflamm Res. 1995 Jan;44(1):1-10. (PMID: 7664022)
Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4810-5. (PMID: 22411812)
RSC Adv. 2023 Jan 18;13(4):2663-2671. (PMID: 36741170)
ACS Appl Bio Mater. 2021 Sep 20;4(9):6937-6945. (PMID: 35006993)
Chin J Integr Med. 2023 Jun;29(6):549-555. (PMID: 37017881)

DST/TDT/AMT/2021/002 Department of Science and Technology, Ministry of Science and Technology, India

Keywords: Biological functions; Biomedical potential; FN-doped carbon dots; Medicinal plants; Zaltoprofen

7440-44-0 (Carbon)
0 (Biocompatible Materials)
0 (Plant Extracts)
0 (Anti-Bacterial Agents)
0 (Antioxidants)

Date Created: 20240607 Date Completed: 20240607 Latest Revision: 20240610

20240611

PMC11161473

10.1038/s41598-024-63700-w

38849424