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Hsa-circ-0006091 modulates the proliferation of hepatocellular carcinoma via the miR-622/CCNB1 axis.
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- المؤلفون: Zhao X;Zhao X; He L; He L
- المصدر:
Turkish journal of medical sciences [Turk J Med Sci] 2023 May 31; Vol. 53 (5), pp. 1367-1378. Date of Electronic Publication: 2023 May 31 (Print Publication: 2023).
- نوع النشر :
Journal Article
- اللغة:
English
- معلومة اضافية
- المصدر:
Publisher: Scientific and Technical Research Council of Turkey Country of Publication: Turkey NLM ID: 9441758 Publication Model: eCollection Cited Medium: Internet ISSN: 1303-6165 (Electronic) Linking ISSN: 13000144 NLM ISO Abbreviation: Turk J Med Sci Subsets: MEDLINE
- بيانات النشر:
Original Publication: Ankara : Scientific and Technical Research Council of Turkey, [1994-
- الموضوع:
- نبذة مختصرة :
Background/aim: Hepatocellular carcinoma (HCC) is a common type of cancer. We hypothesize that circular RNA-0006091 (circ-0006091) affects the progression of HCC. The study aims to investigate the effect of circ-0006091 in HCC cells.
Materials and Methods: The levels of circ-0006091, microRNA-622 (miR-622), and cyclin B1 (CCNB1) were assayed using qRT-PCR and western blotting. The metastasis of the HCC cells was measured with wound healing and transwell assays. The protein expression levels of MMP-2 and MMP-9 were assayed with western blotting. Dual-luciferase reporter and RNA-pulldown assays were used to determine the link between miR-622 and circ-0006091 or CCNB1. Mice-based tests were used to determine the effect of circ-0006091 on the proliferation of HCC cells.
Results: The levels of circ-0006091 and CCNB1 were increased in the HCC cells, but miR-622 was down-regulated. Deficiency of circ-0006091 reduced the metastasis of the HCC cells, and silencing of circ-0006091 decreased the activities of MMP-2 and MMP-9 in the same cells. Circ-0006091 modulated the CCNB1 level in the HCC cells via miR-622. Silencing of circ-0006091 suppressed the proliferation of the HCC cells in vivo.
Conclusion: Circ-0006091 regulated HCC cell metastasis via the miR-622/CCNB1 axis, a possible therapeutic target in managing HCC.
Competing Interests: Conflict of interest: All authors declared that they have no conflicts of interest.
(© TÜBİTAK.)
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- Contributed Indexing:
Keywords: Hepatocellular carcinoma; circ-0006091; cyclin B1; invasion; miR-622; migration
- الرقم المعرف:
0 (CCNB1 protein, human)
0 (Cyclin B1)
EC 3.4.24.35 (Matrix Metalloproteinase 9)
0 (MicroRNAs)
0 (RNA, Circular)
0 (MIRN622 microRNA, human)
- الموضوع:
Date Created: 20240530 Date Completed: 20240530 Latest Revision: 20240606
- الموضوع:
20240606
- الرقم المعرف:
PMC10763780
- الرقم المعرف:
10.55730/1300-0144.5703
- الرقم المعرف:
38813026
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