The effect of macrophages and their exosomes in ischemic heart disease.

Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

Original Publication: [Lausanne : Frontiers Research Foundation]

Exosomes*/metabolism ; Exosomes*/immunology ; Macrophages*/immunology ; Macrophages*/metabolism ; Myocardial Ischemia*/immunology ; Myocardial Ischemia*/metabolism; Humans ; Animals

Ischemic heart disease (IHD) is a leading cause of disability and death worldwide, with immune regulation playing a crucial role in its pathogenesis. Various immune cells are involved, and as one of the key immune cells residing in the heart, macrophages play an indispensable role in the inflammatory and reparative processes during cardiac ischemia. Exosomes, extracellular vesicles containing lipids, nucleic acids, proteins, and other bioactive molecules, have emerged as important mediators in the regulatory functions of macrophages and hold promise as a novel therapeutic target for IHD. This review summarizes the regulatory mechanisms of different subsets of macrophages and their secreted exosomes during cardiac ischemia over the past five years. It also discusses the current status of clinical research utilizing macrophages and their exosomes, as well as strategies to enhance their therapeutic efficacy through biotechnology. The aim is to provide valuable insights for the treatment of IHD.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Wang, Li, Liu, Jin, Yu, Tan and Zhang.)

Adv Drug Deliv Rev. 2016 Nov 15;106(Pt A):148-156. (PMID: 26928656)
In Vitro Cell Dev Biol Anim. 2021 Jan;57(1):30-41. (PMID: 33420578)
Adv Clin Chem. 2020;97:73-116. (PMID: 32448435)
ACS Appl Bio Mater. 2023 Oct 16;6(10):4269-4276. (PMID: 37774367)
Front Cell Dev Biol. 2021 Jun 09;9:673677. (PMID: 34179002)
J Cell Physiol. 2019 Apr;234(4):4217-4231. (PMID: 30132863)
Am J Physiol Cell Physiol. 2016 Jan 1;310(1):C41-53. (PMID: 26491050)
Front Immunol. 2022 May 13;13:894002. (PMID: 35634320)
Cell Rep Med. 2023 Dec 19;4(12):101334. (PMID: 38118414)
Int J Biochem Cell Biol. 2019 Sep;114:105564. (PMID: 31276786)
Exp Ther Med. 2021 Sep;22(3):910. (PMID: 34306184)
Basic Res Cardiol. 2018 Jun 4;113(4):26. (PMID: 29868933)
Pharmacol Ther. 2018 Jun;186:73-87. (PMID: 29330085)
Physiol Rev. 2016 Jul;96(3):1127-68. (PMID: 27335447)
Front Cardiovasc Med. 2022 Jan 17;8:639476. (PMID: 35111821)
Nat Commun. 2013;4:1886. (PMID: 23695680)
Immun Inflamm Dis. 2023 Jun;11(6):e898. (PMID: 37382260)
Eur J Pharmacol. 2020 Mar 15;871:172916. (PMID: 31930970)
Cell. 2017 Apr 20;169(3):510-522.e20. (PMID: 28431249)
Front Cell Dev Biol. 2021 Sep 10;9:704903. (PMID: 34568321)
Biomater Res. 2022 Apr 11;26(1):14. (PMID: 35410296)
Immunity. 2021 Nov 9;54(11):2531-2546.e5. (PMID: 34644537)
J Clin Invest. 2016 Jun 1;126(6):2151-66. (PMID: 27140396)
Circ Res. 2014 Jul 7;115(2):284-95. (PMID: 24786973)
Sci Rep. 2022 Feb 8;12(1):2050. (PMID: 35136090)
Circulation. 2019 Jan 29;139(5):663-678. (PMID: 30586706)
Pharmacol Ther. 2012 May;134(2):156-79. (PMID: 22260952)
Front Cardiovasc Med. 2019 Apr 11;6:42. (PMID: 31032261)
Circ Res. 2020 Sep 25;127(8):953-973. (PMID: 32600176)
Cardiovasc Res. 2014 May 1;102(2):240-8. (PMID: 24501331)
J Cardiovasc Pharmacol Ther. 2021 Jul;26(4):386-395. (PMID: 33550832)
Immunol Res. 2021 Aug;69(4):334-351. (PMID: 34235623)
Front Immunol. 2022 Nov 10;13:1053171. (PMID: 36439111)
Diabetologia. 2019 Dec;62(12):2179-2187. (PMID: 31690986)
Immunometabolism. 2021;3(2):. (PMID: 33927894)
Int J Mol Sci. 2021 Mar 08;22(5):. (PMID: 33800220)
Eur J Pharmacol. 2019 Jul 5;854:307-319. (PMID: 31039343)
Stem Cell Res Ther. 2022 Apr 8;13(1):151. (PMID: 35395872)
Immunol Rev. 2014 Nov;262(1):153-66. (PMID: 25319333)
Neuroscience. 2020 Jun 15;437:161-171. (PMID: 32224230)
Nat Rev Cardiol. 2014 May;11(5):255-65. (PMID: 24663091)
Ann Transl Med. 2020 Nov;8(21):1409. (PMID: 33313154)
Cardiovasc Res. 2020 May 1;116(6):1101-1112. (PMID: 31841135)
Circ J. 2020 Mar 25;84(4):626-635. (PMID: 32161201)
Hypertens Res. 2022 Apr;45(4):650-664. (PMID: 35082376)
Nat Rev Cardiol. 2021 Aug;18(8):547-564. (PMID: 33654273)
Circ Res. 2016 Jun 24;119(1):91-112. (PMID: 27340270)
Adv Clin Exp Med. 2021 Apr;30(4):413-420. (PMID: 33908199)
Theranostics. 2021 Apr 15;11(13):6315-6333. (PMID: 33995660)
Cell Commun Signal. 2023 Aug 14;21(1):202. (PMID: 37580705)
Dis Markers. 2022 May 14;2022:7030722. (PMID: 35607440)
J Control Release. 2022 Jul;347:27-43. (PMID: 35508222)
Adv Sci (Weinh). 2021 May 03;8(13):2100209. (PMID: 34258163)
Nat Rev Immunol. 2008 Dec;8(12):958-69. (PMID: 19029990)
Atherosclerosis. 2017 Jul;262:113-122. (PMID: 28535426)
Semin Nucl Med. 2020 May;50(3):195-207. (PMID: 32284106)
Circ Res. 2014 Sep 26;115(8):730-7. (PMID: 25142002)
Subcell Biochem. 2021;97:19-43. (PMID: 33779912)
Mol Cancer Res. 2019 Feb;17(2):337-347. (PMID: 30487244)
Front Physiol. 2020 Jun 11;11:654. (PMID: 32595526)
Circ Res. 2013 Mar 15;112(6):891-9. (PMID: 23392842)
J Cell Mol Med. 2022 Mar;26(5):1486-1500. (PMID: 35088943)
Basic Res Cardiol. 2017 May;112(3):33. (PMID: 28439731)
Nat Rev Immunol. 2019 May;19(5):273-281. (PMID: 30705422)
J Mol Cell Cardiol. 2014 May;70:74-82. (PMID: 24321195)
J Cell Mol Med. 2022 Oct;26(20):5165-5180. (PMID: 36071548)
Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1782-90. (PMID: 27444197)
Circulation. 2007 Feb 6;115(5):584-92. (PMID: 17283277)
J Mol Cell Cardiol. 2021 Sep;158:38-48. (PMID: 34023353)
Cells. 2021 Jun 15;10(6):. (PMID: 34203713)
ACS Biomater Sci Eng. 2022 Aug 8;8(8):3271-3298. (PMID: 35867701)
Eur J Clin Invest. 2013 Sep;43(9):986-95. (PMID: 23772948)
Circ Res. 2019 Jan 18;124(2):263-278. (PMID: 30582448)
Immunity. 2013 Sep 19;39(3):599-610. (PMID: 24012416)
Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):580-585. (PMID: 28049847)
Science. 2020 Feb 7;367(6478):. (PMID: 32029601)
Circ J. 2006 Jun;70(6):673-8. (PMID: 16723786)
Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16029-34. (PMID: 25349429)
J Cardiovasc Pharmacol. 2023 Oct 01;82(4):287-297. (PMID: 37535964)
Circulation. 2021 Apr 13;143(15):1513-1525. (PMID: 33550817)
Eur Rev Med Pharmacol Sci. 2020 Oct;24(19):10069-10077. (PMID: 33090414)
Regen Biomater. 2022 Sep 05;9:rbac064. (PMID: 36176713)
Circulation. 2019 Mar 5;139(10):e56-e528. (PMID: 30700139)
Nat Immunol. 2018 Jun;19(6):526-537. (PMID: 29777212)
Front Immunol. 2021 Apr 02;12:664457. (PMID: 33868315)
Adv Drug Deliv Rev. 2020;159:332-343. (PMID: 32305351)
J Mol Cell Cardiol. 2007 Nov;43(5):535-44. (PMID: 17689559)
Immunol Res. 2021 Aug;69(4):352-362. (PMID: 34259987)
FASEB J. 2022 Feb;36(2):e22150. (PMID: 34997943)
Am J Respir Cell Mol Biol. 2015 Nov;53(5):676-88. (PMID: 25870903)
Nat Rev Cardiol. 2020 Nov;17(11):685-697. (PMID: 32483304)
Nat Commun. 2016 Jul 22;7:12260. (PMID: 27447449)
J Extracell Vesicles. 2023 Mar;12(3):e12311. (PMID: 36872252)
Front Immunol. 2019 Mar 29;10:648. (PMID: 30984201)
J Cell Physiol. 2019 Apr;234(4):4044-4053. (PMID: 30256395)
Front Immunol. 2022 Jul 18;13:934040. (PMID: 35924253)
Circ Res. 2020 Mar 13;126(6):789-806. (PMID: 32163341)
J Mol Cell Cardiol. 2021 Dec;161:75-85. (PMID: 34371036)
Elife. 2020 Oct 16;9:. (PMID: 33063665)
Circulation. 2022 May 17;145(20):1542-1556. (PMID: 35430895)
Immunobiology. 2018 Jan;223(1):101-111. (PMID: 29032836)
Cell. 2007 Dec 14;131(6):1124-36. (PMID: 18083102)
Oxid Med Cell Longev. 2021 Oct 29;2021:9959746. (PMID: 34745428)
Int J Biol Sci. 2022 Jan 9;18(3):1271-1287. (PMID: 35173552)
Immunobiology. 2019 Mar;224(2):242-253. (PMID: 30739804)
Dev Cell. 2023 Feb 27;58(4):320-334.e8. (PMID: 36800996)
J Leukoc Biol. 2019 Aug;106(2):345-358. (PMID: 30576000)
Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1815-22. (PMID: 18263717)
Circ Res. 2014 May 9;114(10):1611-22. (PMID: 24625784)
JAMA. 2012 Apr 25;307(16):1717-26. (PMID: 22447880)
Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L834-L844. (PMID: 28798256)
Circ Res. 2013 Feb 15;112(4):675-88. (PMID: 23261783)
Adv Sci (Weinh). 2022 May;9(15):e2103222. (PMID: 35332686)
J Cell Mol Med. 2020 Feb;24(4):2593-2609. (PMID: 31930778)
Mol Ther. 2017 Jan 4;25(1):192-204. (PMID: 28129114)
Cell Death Dis. 2019 May 29;10(6):422. (PMID: 31142732)
J Cell Mol Med. 2019 Nov;23(11):7617-7631. (PMID: 31557396)
J Clin Invest. 2023 Feb 15;133(4):. (PMID: 36480284)
Stem Cell Res Ther. 2019 Oct 10;10(1):300. (PMID: 31601262)
Nat Med. 2018 Aug;24(8):1234-1245. (PMID: 29892064)
Heart Surg Forum. 2022 Sep 28;25(5):E698-E708. (PMID: 36317904)
Eur J Clin Invest. 2016 Jun;46(6):590-601. (PMID: 27090739)
Heart Surg Forum. 2019 Jan 28;22(1):E019-E023. (PMID: 30802192)
J Clin Invest. 2005 Mar;115(3):599-609. (PMID: 15711638)
Cells. 2022 Jul 18;11(14):. (PMID: 35883672)
J Mol Cell Cardiol. 2020 May;142:65-79. (PMID: 32087217)
Mol Aspects Med. 2019 Feb;65:70-99. (PMID: 30056242)
Front Immunol. 2017 Mar 15;8:289. (PMID: 28360914)
Pharmacol Res. 2021 Aug;170:105692. (PMID: 34182130)
Theranostics. 2021 Jan 1;11(3):1046-1058. (PMID: 33391520)
Shock. 2019 Mar;51(3):372-380. (PMID: 29470359)
Cell Physiol Biochem. 2015;35(6):2483-500. (PMID: 25967877)
ACS Appl Mater Interfaces. 2021 Dec 8;13(48):56892-56908. (PMID: 34823355)
J Clin Invest. 2021 Mar 15;131(6):. (PMID: 33529176)
Nat Immunol. 2018 Apr;19(4):327-341. (PMID: 29507356)
Basic Res Cardiol. 2020 Feb 28;115(2):22. (PMID: 32112145)
Front Physiol. 2020 Sep 23;11:1113. (PMID: 33071805)
Eur Heart J. 2008 Feb;29(4):445-54. (PMID: 18276618)
Nat Immunol. 2019 Jan;20(1):29-39. (PMID: 30538339)
J Cardiovasc Pharmacol. 2020 Feb;75(2):112-122. (PMID: 31764396)
Chem Rev. 2018 Feb 28;118(4):1917-1950. (PMID: 29384376)
Circulation. 2016 Apr 12;133(15):1484-97; discussion 1497. (PMID: 26933083)
Physiol Int. 2022 Sep 5;:. (PMID: 36057104)
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Dec;1862(12):1595-1605. (PMID: 28964797)
Pharmazie. 2021 Feb 25;76(2):61-67. (PMID: 33714281)
Pharm Biol. 2022 Dec;60(1):384-393. (PMID: 35188856)
Immunity. 2014 Jan 16;40(1):91-104. (PMID: 24439267)
Redox Biol. 2022 Oct;56:102446. (PMID: 36057161)
Circ Res. 2022 Feb 4;130(3):418-431. (PMID: 35113662)
Stem Cell Res Ther. 2013 Nov 01;4(6):134. (PMID: 24405629)
PLoS One. 2017 Nov 9;12(11):e0187894. (PMID: 29121663)
Exp Biol Med (Maywood). 2022 Jun;247(11):958-971. (PMID: 35220781)
Cell Transplant. 2014;23 Suppl 1:S97-104. (PMID: 25302537)
Transl Res. 2018 Jan;191:15-28. (PMID: 29106912)
Circ Res. 2016 Feb 19;118(4):620-36. (PMID: 26892962)
Circ Res. 2022 Nov 11;131(11):893-908. (PMID: 36268709)
Open Rheumatol J. 2012;6:96-102. (PMID: 22802907)
Cell Transplant. 2016;25(8):1461-71. (PMID: 26671426)
PeerJ. 2023 Mar 31;11:e15180. (PMID: 37020848)
PLoS One. 2018 Jan 24;13(1):e0190300. (PMID: 29364896)
J Am Coll Cardiol. 2020 Dec 22;76(25):2982-3021. (PMID: 33309175)
Basic Res Cardiol. 2019 Aug 1;114(5):34. (PMID: 31372765)
PLoS Biol. 2020 Dec 2;18(12):e3000941. (PMID: 33264286)
J Am Heart Assoc. 2018 Aug 7;7(15):e008737. (PMID: 30371236)
Aging (Albany NY). 2021 Jul 1;13(13):17473-17488. (PMID: 34214050)
J Immunol Res. 2022 Jul 4;2022:7685796. (PMID: 35832650)
Sci Rep. 2018 Feb 2;8(1):2267. (PMID: 29396513)
Exp Ther Med. 2019 Jul;18(1):179-187. (PMID: 31258652)

Keywords: exosomes; extracellular vesicles; immune cells; ischemic heart disease; macrophage

Date Created: 20240527 Date Completed: 20240527 Latest Revision: 20240531

20240531

PMC11116575

10.3389/fimmu.2024.1402468

38799471