Changes in Lipid Profiles with the Progression of Pregnancy in Black Women.

Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE

Original Publication: Basel, Switzerland : MDPI AG, [2012]-

Background/Objectives : Lipid metabolism plays an important role in maternal health and fetal development. There is a gap in the knowledge of how lipid metabolism changes during pregnancy for Black women who are at a higher risk of adverse outcomes. We hypothesized that the comprehensive lipidome profiles would show variation across pregnancy indicative of requirements during gestation and fetal development. Methods : Black women were recruited at prenatal clinics. Plasma samples were collected at 8-18 weeks (T 1 ), 22-29 weeks (T 2 ), and 30-36 weeks (T 3 ) of pregnancy. Samples from 64 women who had term births (≥37 weeks gestation) were subjected to "shotgun" Orbitrap mass spectrometry. Mixed-effects models were used to quantify systematic changes and dimensionality reduction models were used to visualize patterns and identify reliable lipid signatures. Results : Total lipids and major lipid classes showed significant increases with the progression of pregnancy. Phospholipids and glycerolipids exhibited a gradual increase from T 1 to T 2 to T 3 , while sphingolipids and total sterol lipids displayed a more pronounced increase from T 2 to T 3 . Acylcarnitines, hydroxy acylcarnitines, and Lyso phospholipid levels significantly decreased from T 1 to T 3 . A deviation was that non-esterified fatty acids decreased from T 1 to T 2 and increased again from T 2 to T 3 , suggestive of a potential role for these lipids during the later stages of pregnancy. The fatty acids showing this trend included key fatty acids-non-esterified Linoleic acid, Arachidonic acid, Alpha-linolenic acid, Eicosapentaenoic acid, Docosapentaenoic acid, and Docosahexaenoic acid. Conclusions : Mapping lipid patterns and identifying lipid signatures would help develop intervention strategies to reduce perinatal health disparities among pregnant Black women.

Clin Cardiol. 2007 Apr;30(4):161-4. (PMID: 17443653)
BMJ Open Diabetes Res Care. 2019 May 16;7(1):e000632. (PMID: 31245005)
Sci Rep. 2020 Aug 26;10(1):14209. (PMID: 32848180)
Diabetes. 2013 Jan;62(1):1-8. (PMID: 23258903)
Nutrients. 2018 Jun 28;10(7):. (PMID: 29958393)
PLoS One. 2020 Nov 17;15(11):e0239115. (PMID: 33201881)
Circulation. 2017 Nov 21;136(21):e393-e423. (PMID: 29061565)
Front Physiol. 2022 Jan 20;12:787848. (PMID: 35126178)
Clin Obstet Gynecol. 2007 Dec;50(4):938-48. (PMID: 17982337)
Ann Nutr Metab. 2017;70(1):59-65. (PMID: 28297696)
Semin Perinatol. 2017 Dec;41(8):511-518. (PMID: 28941962)
Front Endocrinol (Lausanne). 2020 Nov 30;11:611929. (PMID: 33424775)
Early Hum Dev. 1998 Dec;53 Suppl:S43-50. (PMID: 10102654)
J Perinat Med. 1995;23(6):477-85. (PMID: 8904477)
Clin Transl Med. 2018 Jan 26;7(1):4. (PMID: 29374337)
Sci Rep. 2021 Apr 14;11(1):8115. (PMID: 33854141)
Obesity (Silver Spring). 2011 Jul;19(7):1476-81. (PMID: 21394096)
Cell Signal. 2021 Sep;85:110041. (PMID: 33991614)
J Bacteriol. 2018 May 9;200(11):. (PMID: 29581406)
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Mar;1867(3):159106. (PMID: 34995789)
Horm Mol Biol Clin Investig. 2016 May 1;26(2):109-27. (PMID: 26351960)
Endocrinology. 2020 Jul 1;161(7):. (PMID: 32417921)
Curr Pharm Biotechnol. 2014;15(1):24-31. (PMID: 24720597)
J Lipid Res. 2014 Aug;55(8):1797-809. (PMID: 24879804)
J Diabetes Res. 2019 Aug 18;2019:7098470. (PMID: 31531374)
Metabolites. 2021 Dec 17;11(12):. (PMID: 34940643)
Anal Bioanal Chem. 2020 Apr;412(10):2191-2209. (PMID: 31820027)
Obstet Gynecol. 2010 Jul;116(1):107-113. (PMID: 20567175)
Healthcare (Basel). 2023 Feb 03;11(3):. (PMID: 36767014)
BMC Med. 2020 Oct 2;18(1):276. (PMID: 33004027)
Diabetes Care. 2017 Jul;40(7):911-919. (PMID: 28637889)
BMC Med. 2023 Feb 13;21(1):53. (PMID: 36782297)
Am J Public Health. 2021 Sep;111(9):1673-1681. (PMID: 34383557)
Sci Rep. 2021 Oct 26;11(1):21066. (PMID: 34702839)
Biol Res Nurs. 2020 Jul;22(3):354-361. (PMID: 32383404)
J Gerontol A Biol Sci Med Sci. 2016 May;71(5):578-85. (PMID: 26019184)
PLoS One. 2017 Aug 16;12(8):e0183228. (PMID: 28813537)
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:260-6. (PMID: 26343017)
AJP Rep. 2016 Jul;6(3):e329-36. (PMID: 27672481)
J Health Popul Nutr. 2015 Aug 13;33:14. (PMID: 26825664)

UM1TR004404 United States NH NIH HHS; R01MD011575 United States NH NIH HHS; R01 MD011575 United States MD NIMHD NIH HHS; K12TR004374 United States NH NIH HHS; Amendt Heller Award for Newborn Research University of Michigan, Department of Pediatrics Intramural Award; R15MD011465 United States NH NIH HHS

Keywords: African American women; lipid biomarkers; lipid profiles; metabolism; pregnancy

Date Created: 20240525 Latest Revision: 20240919

20240919

PMC11122055

10.3390/jcm13102795

38792337