The Role of Inflammasomes in Heart Failure.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Inflammasomes*/metabolism ; Heart Failure*/metabolism ; Heart Failure*/immunology ; Biomarkers*; Humans ; Animals ; Signal Transduction ; Inflammation/metabolism ; Inflammation/immunology

Heart failure (HF) poses a significant world health challenge due to the increase in the aging population and advancements in cardiac care. In the pathophysiology of HF, the inflammasome has been correlated with the development, progression, and complications of HF disease. Discovering biomarkers linked to inflammasomes enhances understanding of HF diagnosis and prognosis. Directing inflammasome signaling emerges as an innovative therapeutic strategy for managing HF. The present review aims to delve into this inflammatory cascade, understanding its role in the development of HF, its potential role as biomarker, as well as the prospects of modulating inflammasomes as a therapeutic approach for HF.

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Keywords: biomarkers; heart failure; inflammasomes; inflammation; therapeutic modulation

0 (Inflammasomes)
0 (Biomarkers)

Date Created: 20240525 Date Completed: 20240525 Latest Revision: 20240527

20240527

PMC11121241

10.3390/ijms25105372

38791409