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Outbreak of Highly Pathogenic Avian Influenza A(H5N1) Virus in Seals, St. Lawrence Estuary, Quebec, Canada 1 .

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  • معلومة اضافية
    • المصدر:
      Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-
    • الموضوع:
      Influenza A Virus, H5N1 Subtype*/genetics ; Influenza A Virus, H5N1 Subtype*/pathogenicity ; Disease Outbreaks*/veterinary; Animals ; Quebec/epidemiology ; Estuaries ; Influenza in Birds/epidemiology ; Influenza in Birds/virology ; Influenza in Birds/history ; Seals, Earless/virology ; Phylogeny ; Orthomyxoviridae Infections/veterinary ; Orthomyxoviridae Infections/virology ; Orthomyxoviridae Infections/epidemiology ; Birds/virology
    • نبذة مختصرة :
      We describe an unusual mortality event caused by a highly pathogenic avian influenza (HPAI) A(H5N1) virus clade 2.3.4.4b involving harbor (Phoca vitulina) and gray (Halichoerus grypus) seals in the St. Lawrence Estuary, Quebec, Canada, in 2022. Fifteen (56%) of the seals submitted for necropsy were considered to be fatally infected by HPAI H5N1 containing fully Eurasian or Eurasian/North American genome constellations. Concurrently, presence of large numbers of bird carcasses infected with HPAI H5N1 at seal haul-out sites most likely contributed to the spillover of infection to the seals. Histologic changes included meningoencephalitis (100%), fibrinosuppurative alveolitis, and multiorgan acute necrotizing inflammation. This report of fatal HPAI H5N1 infection in pinnipeds in Canada raises concerns about the expanding host of this virus, the potential for the establishment of a marine mammal reservoir, and the public health risks associated with spillover to mammals.Nous décrivons un événement de mortalité inhabituelle causé par un virus de l'influenza aviaire hautement pathogène A(H5N1) clade 2.3.4.4b chez des phoques communs (Phoca vitulina) et gris (Halichoerus grypus) dans l'estuaire du Saint-Laurent au Québec, Canada, en 2022. Quinze (56%) des phoques soumis pour nécropsie ont été considérés comme étant fatalement infectés par le virus H5N1 de lignées eurasiennes ou de réassortiment eurasiennes/nord-américaines. Un grand nombre simultané de carcasses d'oiseaux infectés par le H5N1 sur les sites d'échouement a probablement contribué à la contamination de ces phoques. Les changements histologiques associés à cette infection incluaient : méningo-encéphalite (100%), alvéolite fibrinosuppurée et inflammation nécrosante aiguë multi-organique. Cette documentation soulève des préoccupations quant à l'émergence de virus mortels, à la possibilité d'établissement de réservoirs chez les mammifères marins, et aux risques pour la santé publique associés aux propagations du virus chez les mammifères.
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    • Contributed Indexing:
      Keywords: Canada; H5N1; HPAI; Quebec; St. Lawrence Estuary; avian influenza; encephalitis; highly pathogenic avian influenza; influenza; pinnipeds; respiratory infections; seals; unusual mortality event; viruses
    • الموضوع:
      Date Created: 20240523 Date Completed: 20240523 Latest Revision: 20240603
    • الموضوع:
      20240603
    • الرقم المعرف:
      PMC11138997
    • الرقم المعرف:
      10.3201/eid3006.231033
    • الرقم المعرف:
      38781927