Disease burden of mental disorders among children and adolescents considering both co-morbidities and suicide in Northeastern China.

Publisher: BioMed Central Country of Publication: England NLM ID: 100968562 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2458 (Electronic) Linking ISSN: 14712458 NLM ISO Abbreviation: BMC Public Health Subsets: MEDLINE

Original Publication: London : BioMed Central, [2001-

Mental Disorders*/epidemiology ; Suicide*/statistics & numerical data ; Comorbidity* ; Cost of Illness*; Humans ; Adolescent ; China/epidemiology ; Child ; Male ; Female ; Cross-Sectional Studies ; Disability-Adjusted Life Years ; Child, Preschool

Background: Few studies have assessed the burden of mental disorders among children and adolescents considering the impact of co-morbidities and suicide on disability adjusted life years (DALYs).
Methods: This was a multicenter cross-sectional study. Our survey data in Liaoning Province (LN) were used to estimate the burden of six mental disorders, supplemented with data from other investigative studies conducted in China to assess four other disorders. DALYs were derived from the sum of years lived with a disability (YLDs) adjusted for co-morbidities, and the years of life lost (YLLs) adjusted for suicide. The changes in DALYs, YLDs, and YLLs were compared with and without adjustment for co-morbidities and suicide.
Results: The DALYs rate of mental disorders among children and adolescents in LN decreased from 1579.6/10 ⁵ to 1391.4/10 ⁵ , after adjusting for both co-morbidities and suicide (-11.9%). The DALYs rate for major depression, anxiety disorder, and conduct disorder (-80.8/10 ⁵ , -75.0/10 ⁵ and  -30.2/10 ⁵ , respectively) were the top three contributors to the DALYs reduction (-188.2/10 ⁵ ). The YLDs decreased from 72724.8 to 62478.5 after co-morbidity adjustment (-17.8%), mainly due to the reduction by major depression (-35.3%) and attention deficit/hyperactivity disorder [ADHD] (-34.2%). The YLLs increased from 130 to 1697.8 after adjusting for suicides (+ 56.9% of all suicide YLLs), mainly due to the contribution of major depression (+ 32.4%) and anxiety disorder (+ 10.4%). Compared to GBD 2010, the estimated DALY rate for mental disorders in LN was to be about 80%, with the proportion of DALYs and DALY rates explained by major depressive disorder accounted for only approximately one-third (14.6% vs. 41.9% and 202.6 vs. 759.9, respectively). But the proportion and absolute level of DALY rates explained by anxiety disorders were approximately 2-fold higher (39.7% vs. 19.6% and 552.2 vs. 323.3, respectively).
Conclusions: The DALYs of mental disorders among Chinese children and adolescents were approximately 80% of the global level, with anxiety disorders imposing about 2 times the global level. Co-morbidity and suicide must be adjusted when calculating DALYs.
(© 2024. The Author(s).)

PLoS One. 2014 Apr 02;9(4):e91936. (PMID: 24694747)
J Child Psychol Psychiatry. 2012 Oct;53(10):1036-43. (PMID: 22647074)
Lancet. 2016 Jul 23;388(10042):376-389. (PMID: 27209143)
Lancet Psychiatry. 2022 Feb;9(2):137-150. (PMID: 35026139)
Eur Psychiatry. 2020 Oct 28;63(1):e100. (PMID: 33109292)
Med J Aust. 2013 Sep 16;199(S6):S28-31. (PMID: 25370281)
BMJ. 2019 Feb 6;364:l94. (PMID: 31339847)
Atten Defic Hyperact Disord. 2015 Mar;7(1):27-38. (PMID: 24942707)
J Child Psychol Psychiatry. 2022 Jan;63(1):34-46. (PMID: 34019305)
BMC Psychiatry. 2022 Mar 30;22(1):225. (PMID: 35354437)
Zhongguo Dang Dai Er Ke Za Zhi. 2010 Feb;12(2):123-7. (PMID: 20199729)
Depress Anxiety. 2008;25(9):801-10. (PMID: 17592617)
J Child Psychol Psychiatry. 2015 May;56(5):586-94. (PMID: 25109807)
Transl Psychiatry. 2021 Jan 21;11(1):69. (PMID: 33479212)
Lancet Psychiatry. 2021 Apr;8(4):310-319. (PMID: 33743882)
Lancet. 2017 Sep 16;390(10100):1211-1259. (PMID: 28919117)
Lancet. 2011 Oct 22;378(9801):1515-25. (PMID: 22008427)
Lancet. 2012 Jun 23;379(9834):2318-9. (PMID: 22726503)
Lancet. 2007 Sep 8;370(9590):859-77. (PMID: 17804063)
Eur Neuropsychopharmacol. 2011 Sep;21(9):655-79. (PMID: 21896369)
Lancet. 2013 Apr 20;381(9875):1371-1379. (PMID: 23453885)
Soc Sci Med. 2011 Feb;72(4):608-16. (PMID: 21211874)
Eur Child Adolesc Psychiatry. 2017 Dec;26(12):1443-1457. (PMID: 28527021)
Psychol Med. 2015 May;45(7):1551-63. (PMID: 25534496)
J Anxiety Disord. 2012 Oct;26(7):728-36. (PMID: 22858899)
China CDC Wkly. 2020 Oct 9;2(41):804-809. (PMID: 34594771)
Soc Psychiatry Psychiatr Epidemiol. 2013 Oct;48(10):1591-9. (PMID: 23397319)
Lancet. 2020 Oct 17;396(10258):1204-1222. (PMID: 33069326)
Curr Psychiatry Rep. 2017 Nov 20;19(12):109. (PMID: 29152677)
PLoS One. 2014 Oct 31;9(10):e111223. (PMID: 25360718)

CXTD2022006 Science and Technology Innovation Team of China Medical University

Keywords: Children and adolescents; Co-morbidities; DALYs; Mental disorders; Suicide

Date Created: 20240520 Date Completed: 20240520 Latest Revision: 20240523

20240523

PMC11106940

10.1186/s12889-024-18721-5

38769489