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Aluminium Chloride instead of Ferric chloride for inducing superior sagittal sinus thrombosis to reduce ferromagnetic artifacts on MRI-imaging in experimental models.

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  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Aluminum Chloride* ; Ferric Compounds* ; Magnetic Resonance Imaging*/methods ; Rats, Wistar* ; Artifacts* ; Chlorides*/pharmacology ; Chlorides*/administration & dosage ; Disease Models, Animal*; Animals ; Male ; Rats ; Sagittal Sinus Thrombosis/diagnostic imaging ; Sagittal Sinus Thrombosis/chemically induced ; Aluminum Compounds ; Superior Sagittal Sinus/diagnostic imaging ; Superior Sagittal Sinus/drug effects
    • نبذة مختصرة :
      Using ferric chloride (FeCl3) to induce experimental superior sagittal sinus (SSS) thrombosis might interfere with magnetic resonance imaging (MRI)-assisted visualization and evaluation of the thrombus, the brain parenchyma, and the quality of the occlusion. The aim of this study was to investigate whether aluminum chloride (AlCl3)-induced thrombosis of the SSS has comparable properties to those of FeCl3 without causing artifacts in MRI. SSS thrombosis was induced in 14 male Wistar rats by exposure of the SSS and subsequent topical application of a filter paper strip soaked in AlCl3 (n = 7) or FeCl3 (n = 7) over a period of 15 min. The animals with AlCl3-induced SSS thrombosis showed a constant and complete occlusion with in histological analysis large thrombi. Blood flow measurements indicated a significant reduction on the first and seventh postoperative day compared to preoperative measurements. MRI enabled visualization and subsequent evaluation of the thrombus and the surrounding parenchyma. In comparison, FeCl3-induced SSS thrombosis could not be evaluated by MRI due to artifacts caused by the paramagnetic properties and increased susceptibility of FeCl3. The occluded sinus and the surrounding area appeared hypointense. The quality of SSS occlusion by AlCl3 was comparable to that of FeCl3. AlCl3 therefore represents a significant alternative substance in experimental SSS thrombosis ideally suited for studies using MRI.
      (© 2024. The Author(s).)
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    • Contributed Indexing:
      Keywords: Brain; Magnetic Resonance Imaging; Rats; Sinus thrombosis; Stroke
    • الموضوع:
      Date Created: 20240514 Date Completed: 20240515 Latest Revision: 20240518
    • الموضوع:
      20240518
    • الرقم المعرف:
      PMC11094183
    • الرقم المعرف:
      10.1038/s41598-024-61885-8
    • الرقم المعرف:
      38745068