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Redox balance and immunity of piglets pre- and post-E. coli challenge after treatment with hemp or fish oil, and vitamin E.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Vitamin E*/pharmacology ; Fish Oils*/pharmacology ; Fish Oils*/administration & dosage ; Cannabis*/chemistry ; Oxidation-Reduction*/drug effects ; Escherichia coli* ; Dietary Supplements* ; Escherichia coli Infections*/immunology ; Escherichia coli Infections*/veterinary ; Escherichia coli Infections*/drug therapy ; Escherichia coli Infections*/prevention & control; Animals ; Swine ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Oxidative Stress/drug effects ; Weaning ; Lipid Peroxidation/drug effects ; Swine Diseases/microbiology ; Swine Diseases/immunology ; Swine Diseases/prevention & control ; Swine Diseases/drug therapy
    • نبذة مختصرة :
      This study investigated the influence of polyunsaturated fatty acid composition and vitamin E supplementation on oxidative status and immune responses in weanling piglets pre- and post-E. coli challenge. Suckling piglets (n = 24) were randomly selected from two litters for an oral supplementation (1 mL/day) with fish oil or hemp oil and vitamin E supplementation (60 mg natural vitamin E/mL oil) from day 10 to 28 of age. At day 29 and 30 of age, each piglet was orally inoculated with 6.7 × 10 8 and 3.96 × 10 8  CFU of F4 and F18 E. coli, respectively. Blood was sampled from all piglets on day 28 before E. coli challenge and on day 35 of age to investigate immunological and oxidative stress markers in plasma. One week after weaning and exposure to E. coli, a general reduction in the α-tocopherol concentration and activity of GPX1 was obtained. Vitamin E supplementation lowered the extent of lipid peroxidation and improved the antioxidative status and immune responses after E. coli challenge. Hemp oil had the greatest effect on antioxidant enzyme activity. Provision of hemp oil and vitamin E to suckling piglets may reduce the incidence of post-weaning diarrhea.
      (© 2024. The Author(s).)
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    • Grant Information:
      PhD-grant at Aarhus University as part of the PIG-PARADIGM project Novo Nordisk Fonden
    • Contributed Indexing:
      Keywords: Antioxidants; Biomarkers; Enteric infection; Fatty acid composition; Oxidative stress; Pigs
    • الموضوع:
      Date Created: 20240514 Date Completed: 20240514 Latest Revision: 20240518
    • الموضوع:
      20240518
    • الرقم المعرف:
      PMC11093994
    • الرقم المعرف:
      10.1038/s41598-024-61927-1
    • الرقم المعرف:
      38744900