Gelatin Enhances the Wet Mechanical Properties of Poly(D,L-Lactic Acid) Membranes.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Gelatin*/chemistry ; Membranes, Artificial* ; Polyesters*/chemistry; Biocompatible Materials/chemistry ; Materials Testing ; Stress, Mechanical ; Tissue Engineering/methods ; Water/chemistry

Biodegradable (BP) poly(D,L-lactic acid) (PDLLA) membranes are widely used in tissue engineering. Here, we investigate the effects of varying concentrations of PDLLA/gelatin membranes electrospun in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP; C 3 H 2 F 6 O) solvent on their mechanical and physical properties as well as their biocompatibility. Regardless of the environmental conditions, increasing the gelatin content resulted in elevated stress and reduced strain at membrane failure. There was a remarkable difference in strain-to-failure between dry and wet PDLLA/gelatin membranes, with wet strains consistently higher than those of the dry membranes because of the hydrophilic nature of gelatin. A similar wet strain (ε w = 2.7-3.0) was observed in PDLLA/gelatin membranes with a gelatin content between 10 and 40%. Both dry and wet stresses increased with increasing gelatin content. The dry stress on PDLLA/gelatin membranes (σ d = 6.7-9.7 MPa) consistently exceeded the wet stress (σ w = 4.5-8.6 MPa). The water uptake capacity (WUC) improved, increasing from 57% to 624% with the addition of 40% gelatin to PDLLA. PDLLA/gelatin hybrid membranes containing 10 to 20 wt% gelatin exhibited favorable wet mechanical properties (σ w = 5.4-6.3 MPa; ε w = 2.9-3.0); WUC (337-571%), degradability (11.4-20.2%), and excellent biocompatibility.

Braz J Med Biol Res. 1999 Feb;32(2):171-80. (PMID: 10347752)
Int J Mol Sci. 2023 Apr 28;24(9):. (PMID: 37175693)
Molecules. 2017 Dec 13;22(12):. (PMID: 29236060)
Biomed Rep. 2015 Sep;3(5):617-620. (PMID: 26405534)
Plast Reconstr Surg. 1988 May;81(5):672-6. (PMID: 3362985)
J Periodontal Res. 1988 Mar;23(2):107-17. (PMID: 2967362)
Int J Pharm. 2017 Oct 5;531(1):67-79. (PMID: 28807566)
Biomed Mater. 2007 Sep;2(3):S106-10. (PMID: 18458452)
Nanoscale. 2022 Mar 10;14(10):3865-3877. (PMID: 35201252)
J Biomed Mater Res. 2000;53(4):438-43. (PMID: 10898886)
J Clin Periodontol. 1984 Jan;11(1):41-52. (PMID: 6363461)
Mater Sci Eng C Mater Biol Appl. 2013 Apr 1;33(3):1228-35. (PMID: 23827565)
Sci Technol Adv Mater. 2012 Nov 23;13(6):064210. (PMID: 27877537)
Mater Sci Eng C Mater Biol Appl. 2016 Mar;60:143-150. (PMID: 26706517)
Polymers (Basel). 2023 Sep 21;15(18):. (PMID: 37765697)
Biomaterials. 2008 Dec;29(34):4532-9. (PMID: 18757094)
Int J Mol Sci. 2015 Aug 05;16(8):18149-84. (PMID: 26251901)
J Clin Periodontol. 2008 Sep;35(8 Suppl):106-16. (PMID: 18724845)
Biomaterials. 2007 Dec;28(35):5298-306. (PMID: 17765302)
J Pharm Biomed Anal. 1995 May;13(6):747-60. (PMID: 7669829)
J Biomed Mater Res B Appl Biomater. 2012 Jul;100(5):1435-43. (PMID: 22287502)
Med Oral Patol Oral Cir Bucal. 2012 Mar 01;17(2):e301-10. (PMID: 22143705)
Int J Mol Sci. 2023 Feb 10;24(4):. (PMID: 36834993)
Polymers (Basel). 2022 Nov 15;14(22):. (PMID: 36433049)
Mater Sci Eng C Mater Biol Appl. 2017 Mar 1;72:113-117. (PMID: 28024566)
Biomed Mater. 2009 Jun;4(3):035002. (PMID: 19390143)

S3301367 Ministry of SMEs and Startups (MSS, Republic of Korea)

Keywords: absorbable periodontal bone regeneration; biocompatibility; electrospinning; gelatin; poly(D,L-lactic acid) (PDLLA); wet mechanical properties

0 (Biocompatible Materials)
9000-70-8 (Gelatin)
0 (Membranes, Artificial)
459TN2L5F5 (poly(lactide))
0 (Polyesters)
059QF0KO0R (Water)

Date Created: 20240511 Date Completed: 20240511 Latest Revision: 20240701

20240702

PMC11084932

10.3390/ijms25095022

38732241