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A novel anti-pruritic: Topical co-administration of high molecular weight hyaluronan (HMWH) with protamine, a transdermal transport enhancer.
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- المؤلفون: Green PG;Green PG;Green PG; Levine JD; Levine JD; Levine JD
- المصدر:
Molecular pain [Mol Pain] 2024 Jan-Dec; Vol. 20, pp. 17448069241254455.
- نوع النشر :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
- اللغة:
English
- معلومة اضافية
- المصدر:
Publisher: Sage Publications Inc Country of Publication: United States NLM ID: 101242662 Publication Model: Print Cited Medium: Internet ISSN: 1744-8069 (Electronic) Linking ISSN: 17448069 NLM ISO Abbreviation: Mol Pain Subsets: MEDLINE
- بيانات النشر:
Publication: 2016- : Thousand Oaks, CA : Sage Publications Inc.
Original Publication: [London] : BioMed Central, 2005-
- الموضوع:
- نبذة مختصرة :
Pruritis, the sensation of itch, is produced by multiple substances, exogenous and endogenous, that sensitizes specialized sensory neurons (pruriceptors and pruri-nociceptors). Unfortunately, many patients with acute and chronic pruritis obtain only partial relief when treated with currently available treatment modalities. We recently demonstrated that the topical application of high molecular weight hyaluronan (HMWH), when combined with vehicles containing transdermal transport enhancers, produce potent long-lasting reversal of nociceptor sensitization associated with inflammatory and neuropathic pain. In the present experiments we tested the hypothesis that the topical formulation of HMWH with protamine, a transdermal transport enhancer, can also attenuate pruritis. We report that this topical formulation of HMWH markedly attenuates scratching behavior at the nape of the neck induced by serotonin (5-hydroxytryptamine, 5-HT), in male and female rats. Our results support the hypothesis that topical HMWH in a transdermal transport enhancer vehicle is a strong anti-pruritic.
Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- Grant Information:
R01 AR075334 United States AR NIAMS NIH HHS
- Contributed Indexing:
Keywords: 5-hydroxytryptamine; Hyaluronan; itch; topical anti-pruritic; transdermal transporter
- الرقم المعرف:
9004-61-9 (Hyaluronic Acid)
0 (Protamines)
333DO1RDJY (Serotonin)
- الموضوع:
Date Created: 20240510 Date Completed: 20240510 Latest Revision: 20240513
- الموضوع:
20240513
- الرقم المعرف:
PMC11088296
- الرقم المعرف:
10.1177/17448069241254455
- الرقم المعرف:
38728068
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