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Regorafenib with immunotherapy versus regorafenib alone as second-line treatment for hepatocellular carcinoma: A multicenter real-world study.
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- معلومة اضافية
- المصدر:
Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE
- بيانات النشر:
Original Publication: [Malden, MA] : John Wiley & Sons Ltd., c2012-
- الموضوع:
- نبذة مختصرة :
Introduction: Regorafenib remains the standard and widely used second-line strategy for advanced hepatocellular carcinoma (HCC). There is still a lack of large-scale multicenter real-world evidence concerning the concurrent use of regorafenib with immune checkpoint inhibitors (ICI). This study aims to evaluate whether combining regorafenib with ICI provides greater clinical benefit than regorafenib monotherapy as second-line therapy for advanced HCC under real-world circumstances.
Patients and Methods: The study included 208 patients from five medical facilities. One hundred forty-three patients received regorafenib plus ICI combination therapy, while 65 patients received regorafenib monotherapy. Propensity score matching (PSM) analysis was employed.
Results: The regorafenib plus ICI group demonstrated significantly higher objective response rate (24.3% vs. 10.3%, after PSM, p = 0.030) and disease control rate (79.4% vs. 50.0%, after PSM, p < 0.001) compared to the regorafenib monotherapy group based on mRECIST criteria. Median progression-free survival (7.9 vs. 3.2 months, after PSM, p < 0.001) and overall survival (25.6 vs. 16.4 months, p = 0.010, after PSM) were also considerably longer in the regorafenib plus ICI group. The incidence of Grades 3-4 treatment-related adverse events (TRAEs) was marginally greater in the regorafenib plus ICI group than in the regorafenib group (23.8% vs. 20.0%, p = 0.546). Notably, there were no instances of treatment-related mortality or emergence of new TRAEs in any treatment group.
Conclusion: The combination of regorafenib and ICI shows potential as a viable second-line treatment for advanced HCC, exhibiting favorable efficacy while maintaining a tolerable safety profile in contrast to regorafenib monotherapy.
(© 2024 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
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- Contributed Indexing:
Keywords: hepatocellular carcinoma; immune checkpoint inhibitor; multicenter; regorafenib; second‐line therapy
- الرقم المعرف:
24T2A1DOYB (regorafenib)
0 (Pyridines)
0 (Phenylurea Compounds)
0 (Immune Checkpoint Inhibitors)
- الموضوع:
Date Created: 20240508 Date Completed: 20240508 Latest Revision: 20240617
- الموضوع:
20240618
- الرقم المعرف:
PMC11077333
- الرقم المعرف:
10.1002/cam4.7236
- الرقم المعرف:
38716585
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