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Synthetic molecular switches driven by DNA-modifying enzymes.

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اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Kang H;Kang H;Kang H; Yang Y; Yang Y; Wei B; Wei B
  • المصدر:
    Nature communications [Nat Commun] 2024 May 06; Vol. 15 (1), pp. 3781. Date of Electronic Publication: 2024 May 06.
  • نوع النشر :
    Journal Article; Research Support, Non-U.S. Gov't
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: [London] : Nature Pub. Group
    • الموضوع:
      DNA*/chemistry ; DNA*/metabolism ; Nanostructures*/chemistry ; DNA-Directed DNA Polymerase*/metabolism ; DNA-Directed DNA Polymerase*/chemistry; Nucleic Acid Conformation ; Deoxyribonuclease I/metabolism ; Deoxyribonuclease I/chemistry ; Nanotechnology/methods
    • نبذة مختصرة :
      Taking inspiration from natural systems, in which molecular switches are ubiquitous in the biochemistry regulatory network, we aim to design and construct synthetic molecular switches driven by DNA-modifying enzymes, such as DNA polymerase and nicking endonuclease. The enzymatic treatments on our synthetic DNA constructs controllably switch ON or OFF the sticky end cohesion and in turn cascade to the structural association or disassociation. Here we showcase the concept in multiple DNA nanostructure systems with robust assembly/disassembly performance. The switch mechanisms are first illustrated in minimalist systems with a few DNA strands. Then the ON/OFF switches are realized in complex DNA lattice and origami systems with designated morphological changes responsive to the specific enzymatic treatments.
      (© 2024. The Author(s).)
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    • Grant Information:
      2021YFF1200200 Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology)
    • الرقم المعرف:
      9007-49-2 (DNA)
      EC 2.7.7.7 (DNA-Directed DNA Polymerase)
      EC 3.1.21.1 (Deoxyribonuclease I)
    • الموضوع:
      Date Created: 20240506 Date Completed: 20240506 Latest Revision: 20240509
    • الموضوع:
      20240509
    • الرقم المعرف:
      PMC11074287
    • الرقم المعرف:
      10.1038/s41467-024-47742-2
    • الرقم المعرف:
      38710688