Histology-specific standardized incidence ratio improves the estimation of second primary lung cancer risk.

Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE

Original Publication: [London] : BioMed Central, 2003-

Lung Neoplasms*/epidemiology ; Lung Neoplasms*/pathology ; Neoplasms, Second Primary*/epidemiology ; Neoplasms, Second Primary*/pathology; Humans ; Female ; Male ; Incidence ; Aged ; Middle Aged ; Germany/epidemiology ; Registries ; Risk Assessment/methods ; Aged, 80 and over ; United States/epidemiology ; Risk Factors ; Adult

Background: Lung cancer (LC) survivors are at increased risk for developing a second primary cancer (SPC) compared to the general population. While this risk is particularly high for smoking-related SPCs, the published standardized incidence ratio (SIR) for lung cancer after lung cancer is unexpectedly low in countries that follow international multiple primary (IARC/IACR MP) rules when compared to the USA, where distinct rules are employed. IARC/IACR rules rely on histology-dependent documentation of SPC with the same location as the first cancer and only classify an SPC when tumors present different histology. Thus, SIR might be underestimated in cancer registries using these rules. This study aims to assess whether using histology-specific reference rates for calculating SIR improves risk estimates for second primary lung cancer (SPLC) in LC survivors.
Methods: We (i) use the distribution of histologic subtypes of LC in population-based cancer registry data of 11 regional cancer registries from Germany to present evidence that the conventional SIR metric underestimates the actual risk for SPLC in LC survivors in registries that use IARC/IACR MP rules, (ii) present updated risk estimates for SPLC in Germany using a novel method to calculate histological subtype-specific SIRs, and (iii) validate this new method using US SEER (Surveillance, Epidemiology, and End Results Program) data, where different MP rules are applied.
Results: The adjusted relative risk for lung cancer survivors in Germany to develop an SPLC was 2.98 (95% CI 2.53-3.49) for females and 1.15 (95% CI 1.03-1.27) for males using the novel histology-specific SIR. When using IARC/IACR MP rules, the conventional SIR underestimates the actual risk for SPLC in LC survivors by approximately 30% for both sexes.
Conclusions: Our proposed histology-specific method makes the SIR metric more robust against MP rules and, thus, more suitable for cross-country comparisons.
(© 2024. The Author(s).)

Cancer Epidemiol. 2017 Dec;51:41-43. (PMID: 29032320)
IARC Sci Publ. 1987;(82):1-406. (PMID: 3329634)
J Thorac Oncol. 2021 Jun;16(6):968-979. (PMID: 33722709)
Gesundheitswesen. 2020 Mar;82(S 01):S62-S71. (PMID: 31663107)
Eur J Cancer Prev. 2005 Aug;14(4):307-8. (PMID: 16030420)
J Thorac Oncol. 2018 Jan;13(1):46-53. (PMID: 28989038)
EBioMedicine. 2022 Apr;78:103951. (PMID: 35313216)
J Natl Cancer Inst. 1998 Sep 16;90(18):1335-45. (PMID: 9747865)
J Thorac Oncol. 2022 Mar;17(3):388-398. (PMID: 34902598)
Int J Cancer. 2018 Mar 15;142(6):1285. (PMID: 29134639)
Thorax. 2019 May;74(5):466-472. (PMID: 30777897)
BMC Med. 2024 May 3;22(1):187. (PMID: 38702684)
CA Cancer J Clin. 2021 May;71(3):209-249. (PMID: 33538338)
Int J Cancer. 2019 Jul 1;145(1):143-153. (PMID: 30613963)
Cancer. 2012 Jun 15;118(12):3153-64. (PMID: 22271645)
Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2370-7. (PMID: 17132767)
JAMA. 2020 Dec 22;324(24):2521-2535. (PMID: 33351041)

Keywords: Cancer epidemiology; Cancer registry data; Lung cancer; Second primary cancer; Standardized incidence ratio

Date Created: 20240503 Date Completed: 20240504 Latest Revision: 20240507

20240507

PMC11069219

10.1186/s12916-024-03398-9

38702684