Predictive value of lactate dehydrogenase for Mycoplasma pneumoniae necrotizing pneumonia in children based on decision curve analysis and dose-response analysis.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

L-Lactate Dehydrogenase*/blood ; Pneumonia, Mycoplasma*/diagnosis ; Pneumonia, Mycoplasma*/blood ; Mycoplasma pneumoniae* ; Pneumonia, Necrotizing*/diagnosis; Humans ; Male ; Female ; Child ; Child, Preschool ; Retrospective Studies ; Prognosis ; Infant ; Predictive Value of Tests ; Biomarkers/blood ; Decision Support Techniques

Mycoplasma pneumoniae necrotizing pneumonia (MPNP) has a long and severe disease course, which seriously threatens to jeopardize patients' lives and health. Early prediction is essential for good recovery and prognosis. In the present study, we retrospect 128 children with MPNP and 118 children with Mycoplasma pneumoniae pneumonia combined with pulmonary consolidation to explore the predictive value of lactate dehydrogenase (LDH) in children with MPNP by propensity score matching method, multiple logistic regression analysis, dose-response analysis and decision curve analysis. The WBC count, PLT count and percentage of neutrophils were significantly higher in necrosis group than consolidation group. The serum CRP, PCT, ESR, D-D, FIB, ALT, LDH, IgG and IgM were significantly higher in necrosis group. Compared to consolidation group, necrosis group is more severe in chest pain and dyspnea. Multivariate logistic regression analysis showed that duration of LDH levels, high fever, D-dimer, and fibrinogen were independent predictive factors for the incidence of MPNP. Restricted cubic spline analysis showed that a non-linear dose-response relationship between the continuous changes of LDH level and the incidence of MPNP. Decision curve analysis revealed that LDH had an important clinical value in predicting MPNP. This study provides a potential serologic indicator for early diagnosis of MPNP.
(© 2024. The Author(s).)

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LHGJ20220712 Henan Province Science and Technology Joint Construction Project; LHGJ20220724 Henan Province Science and Technology Joint Construction Project

EC 1.1.1.27 (L-Lactate Dehydrogenase)
0 (Biomarkers)

Date Created: 20240429 Date Completed: 20240429 Latest Revision: 20240502

20250114

PMC11059402

10.1038/s41598-024-60359-1

38684810