Bifidobacterium longum Subsp. infantis Promotes IgA Level of Growing Mice in a Strain-Specific and Intestinal Niche-Dependent Manner.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Immunoglobulin A*/metabolism ; Mice, Inbred BALB C* ; Intestinal Mucosa*/immunology ; Intestinal Mucosa*/microbiology ; Intestinal Mucosa*/metabolism ; Probiotics*/administration & dosage ; Bifidobacterium* ; Bifidobacterium longum subspecies infantis*; Animals ; Female ; Male ; Mice ; Gastrointestinal Microbiome ; Animals, Newborn ; Intestines/microbiology ; Intestines/immunology ; Immunity, Mucosal ; Species Specificity ; Colon/microbiology ; Colon/immunology ; Colon/metabolism ; Immunoglobulin A, Secretory/metabolism

Throughout infancy, IgA is crucial for maintaining gut mucosal immunity. This study aims to determine whether supplementing newborn mice with eight different strains of Bifidobacterium longum subsp. infantis might regulate their IgA levels. The strains were gavaged to BALB/C female ( n = 8) and male ( n = 8) dams at 1-3 weeks old. Eight strains of B. longum subsp. infantis had strain-specific effects in the regulation of intestinal mucosal barriers. B6MNI, I4MI, and I10TI can increase the colonic IgA level in females and males. I8TI can increase the colonic IgA level in males. B6MNI was also able to significantly increase the colonic sIgA level in females. B6MNI, I4MI, I8TI, and I10TI regulated colonic and Peyer's patch IgA synthesis genes but had no significant effect on IgA synthesis pathway genes in the jejunum and ileum. Moreover, the variety of sIgA-coated bacteria in male mice was changed by I4MI, I5TI, I8TI, and B6MNI. These strains also can decrease the relative abundance of Escherichia coli . These results indicate that B. longum subsp. infantis can promote IgA levels but show strain specificity. Different dietary habits with different strains of Bifidobacterium may have varying effects on IgA levels when supplemented in early infancy.

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2021YFD2100700 National Key R&D Program of China; 32021005 National Natural Science Foundation of China; BP0719028 111 project; Not applicable Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province

Keywords: Bifidobacterium longum subsp. infantis; IgA level; gut microbiota; intestinal mucosal immunity; sIgA-coated bacteria

0 (Immunoglobulin A)
0 (Immunoglobulin A, Secretory)

Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240429

20240429

PMC11054607

10.3390/nu16081148

38674840