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Manganese- and Platinum-Driven Oxidative and Nitrosative Stress in Oxaliplatin-Associated CIPN with Special Reference to Ca 4 Mn(DPDP) 5 , MnDPDP and DPDP.
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- المؤلفون: Karlsson JOG;Karlsson JOG; Jynge P; Jynge P
- المصدر:
International journal of molecular sciences [Int J Mol Sci] 2024 Apr 15; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 15.
- نوع النشر :
Journal Article; Review
- اللغة:
English
- معلومة اضافية
- المصدر:
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
- بيانات النشر:
Original Publication: Basel, Switzerland : MDPI, [2000-
- الموضوع:
- نبذة مختصرة :
Platinum-containing chemotherapeutic drugs are efficacious in many forms of cancer but are dose-restricted by serious side effects, of which peripheral neuropathy induced by oxidative-nitrosative-stress-mediated chain reactions is most disturbing. Recently, hope has been raised regarding the catalytic antioxidants mangafodipir (MnDPDP) and calmangafodipir [Ca 4 Mn(DPDP) 5 ; PledOx ® ], which by mimicking mitochondrial manganese superoxide dismutase (MnSOD) may be expected to overcome oxaliplatin-associated chemotherapy-induced peripheral neuropathy (CIPN). Unfortunately, two recent phase III studies (POLAR A and M trials) applying Ca 4 Mn(DPDP) 5 in colorectal cancer (CRC) patients receiving multiple cycles of FOLFOX6 (5-FU + oxaliplatin) failed to demonstrate efficacy. Instead of an anticipated 50% reduction in the incidence of CIPN in patients co-treated with Ca 4 Mn(DPDP) 5 , a statistically significant increase of about 50% was seen. The current article deals with confusing differences between early and positive findings with MnDPDP in comparison to the recent findings with Ca 4 Mn(DPDP) 5 . The POLAR failure may also reveal important mechanisms behind oxaliplatin-associated CIPN itself. Thus, exacerbated neurotoxicity in patients receiving Ca 4 Mn(DPDP) 5 may be explained by redox interactions between Pt 2+ and Mn 2+ and subtle oxidative-nitrosative chain reactions. In peripheral sensory nerves, Pt 2+ presumably leads to oxidation of the Mn 2+ from Ca 4 Mn(DPDP) 5 as well as from Mn 2+ in MnSOD and other endogenous sources. Thereafter, Mn 3+ may be oxidized by peroxynitrite (ONOO - ) into Mn 4+ , which drives site-specific nitration of tyrosine (Tyr) 34 in the MnSOD enzyme. Conformational changes of MnSOD then lead to the closure of the superoxide (O 2 •- ) access channel. A similar metal-driven nitration of Tyr74 in cytochrome c will cause an irreversible disruption of electron transport. Altogether, these events may uncover important steps in the mechanism behind Pt 2+ -associated CIPN. There is little doubt that the efficacy of MnDPDP and its therapeutic improved counterpart Ca 4 Mn(DPDP) 5 mainly depends on their MnSOD-mimetic activity when it comes to their potential use as rescue medicines during, e.g., acute myocardial infarction. However, pharmacokinetic considerations suggest that the efficacy of MnDPDP on Pt 2+ -associated neurotoxicity depends on another action of this drug. Electron paramagnetic resonance (EPR) studies have demonstrated that Pt 2+ outcompetes Mn 2+ and endogenous Zn 2+ in binding to fodipir (DPDP), hence suggesting that the previously reported protective efficacy of MnDPDP against CIPN is a result of chelation and elimination of Pt 2+ by DPDP, which in turn suggests that Mn 2+ is unnecessary for efficacy when it comes to oxaliplatin-associated CIPN.
- References:
J Clin Oncol. 2000 Aug;18(16):2938-47. (PMID: 10944126)
J Clin Oncol. 2004 Jan 1;22(1):23-30. (PMID: 14665611)
Redox Biol. 2014 Jan 18;2:289-95. (PMID: 24494204)
N Engl J Med. 2018 Jun 21;378(25):2376-2385. (PMID: 29924955)
J Clin Invest. 2014 Jan;124(1):262-72. (PMID: 24355920)
Mol Cancer Ther. 2009 Jan;8(1):10-6. (PMID: 19139108)
Curr Colorectal Cancer Rep. 2013;9:261-269. (PMID: 24032000)
Drug Discov Today. 2015 Apr;20(4):411-21. (PMID: 25463039)
Cell Death Differ. 2001 Dec;8(12):1143-56. (PMID: 11753563)
Pain. 2013 Nov;154(11):2432-2440. (PMID: 23891899)
Acta Oncol. 2018 Mar;57(3):393-402. (PMID: 29140155)
Oncologist. 2008 Oct;13(10):1074-83. (PMID: 18922828)
Transl Oncol. 2012 Dec;5(6):492-502. (PMID: 23323161)
Redox Biol. 2018 Apr;14:618-625. (PMID: 29154193)
Cancer Res. 2005 Feb 1;65(3):948-56. (PMID: 15705895)
J Neurosci. 2012 May 2;32(18):6149-60. (PMID: 22553021)
Acta Radiol. 1997 Jul;38(4 Pt 2):677-89. (PMID: 9245963)
J Natl Cancer Inst. 2006 Feb 15;98(4):223-5. (PMID: 16478735)
Cancer Res. 2002 Sep 1;62(17):4854-9. (PMID: 12208730)
Acta Oncol. 2009;48(4):633-5. (PMID: 19169914)
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3611-6. (PMID: 12655051)
J Natl Cancer Inst. 2006 Feb 15;98(4):236-44. (PMID: 16478742)
Anticancer Res. 2002 Jul-Aug;22(4):2301-9. (PMID: 12174918)
Nat Rev Cancer. 2022 Feb;22(2):102-113. (PMID: 34764459)
Acta Oncol. 2018 Jun;57(6):862-864. (PMID: 29243552)
Cochrane Database Syst Rev. 2014 Mar 31;(3):CD005228. (PMID: 24687190)
Mol Pharmacol. 2010 Jun;77(6):887-94. (PMID: 20159940)
BMC Clin Pharmacol. 2008 Sep 17;8:7. (PMID: 18796166)
J Neurol Neurosurg Psychiatry. 2017 Oct;88(10):839-845. (PMID: 28780535)
JNCI Cancer Spectr. 2022 Nov 1;6(6):. (PMID: 36308441)
J Biol Inorg Chem. 2002 Mar;7(3):241-8. (PMID: 11935348)
Ann Intern Med. 1995 Mar 1;122(5):321-6. (PMID: 7847642)
N Engl J Med. 2004 Jun 3;350(23):2343-51. (PMID: 15175436)
Lancet Oncol. 2017 Jan;18(1):63-74. (PMID: 27914822)
J Clin Oncol. 2004 Jan 1;22(1):31-8. (PMID: 14701765)
Int J Cancer. 2011 Feb 1;128(3):682-90. (PMID: 20473862)
Clin Cancer Res. 2000 Apr;6(4):1205-18. (PMID: 10778943)
Antioxidants (Basel). 2023 Mar 01;12(3):. (PMID: 36978857)
J Clin Oncol. 1998 Jan;16(1):295-300. (PMID: 9440756)
Transl Oncol. 2012 Aug;5(4):252-9. (PMID: 22937177)
Sci Rep. 2019 Nov 1;9(1):15813. (PMID: 31676855)
Acc Chem Res. 2013 Feb 19;46(2):550-9. (PMID: 23157446)
- Grant Information:
XXXX Karlsson-Tuner Invest AS; 001 Karlsson-Tuner Invest AS
- Contributed Indexing:
Keywords: MnSOD mimetics; calmangafodipir; chelation therapy; mangafodipir; manganese; nitrosative stress; oxaliplatin-associated CIPN; oxidative stress; platinum
- الرقم المعرف:
0 (Antineoplastic Agents)
9G34HU7RV0 (Edetic Acid)
42Z2K6ZL8P (Manganese)
P28BIW0UTB (N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid)
04ZR38536J (Oxaliplatin)
49DFR088MY (Platinum)
5V5IOJ8338 (Pyridoxal Phosphate)
EC 1.15.1.1 (Superoxide Dismutase)
- الموضوع:
Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240513
- الموضوع:
20240513
- الرقم المعرف:
PMC11050347
- الرقم المعرف:
10.3390/ijms25084347
- الرقم المعرف:
38673932
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