Inflammation and Organic Cation Transporters Novel (OCTNs).

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, 2011-

Inflammation*/metabolism ; Solute Carrier Family 22 Member 5*/metabolism ; Solute Carrier Family 22 Member 5*/genetics ; Organic Cation Transport Proteins*/metabolism ; Organic Cation Transport Proteins*/genetics ; Symporters*; Humans ; Animals ; Ergothioneine/metabolism ; Crohn Disease/metabolism ; Crohn Disease/genetics ; Crohn Disease/pathology ; Arthritis, Rheumatoid/metabolism ; Arthritis, Rheumatoid/genetics ; Gastrointestinal Microbiome ; Carnitine/metabolism ; Asthma/metabolism ; Asthma/genetics ; Acetylcholine/metabolism

Inflammation is a physiological condition characterized by a complex interplay between different cells handled by metabolites and specific inflammatory-related molecules. In some pathological situations, inflammation persists underlying and worsening the pathological state. Over the years, two membrane transporters namely OCTN1 (SLC22A4) and OCTN2 (SLC22A5) have been shown to play specific roles in inflammation. These transporters form the OCTN subfamily within the larger SLC22 family. The link between these proteins and inflammation has been proposed based on their link to some chronic inflammatory diseases such as asthma, Crohn's disease (CD), and rheumatoid arthritis (RA). Moreover, the two transporters show the ability to mediate the transport of several compounds including carnitine, carnitine derivatives, acetylcholine, ergothioneine, and gut microbiota by-products, which have been specifically associated with inflammation for their anti- or proinflammatory action. Therefore, the absorption and distribution of these molecules rely on the presence of OCTN1 and OCTN2, whose expression is modulated by inflammatory cytokines and transcription factors typically activated by inflammation. In the present review, we wish to provide a state of the art on OCTN1 and OCTN2 transport function and regulation in relationships with inflammation and inflammatory diseases focusing on the metabolic signature collected in different body districts and gene polymorphisms related to inflammatory diseases.

Toxicol Mech Methods. 2013 Feb;23(2):68-76. (PMID: 22900493)
Int J Mol Sci. 2020 Mar 05;21(5):. (PMID: 32150922)
Biochem Biophys Res Commun. 1998 May 29;246(3):589-95. (PMID: 9618255)
J Clin Invest. 2021 Jan 4;131(1):. (PMID: 33141762)
PLoS One. 2010 Nov 08;5(11):e15376. (PMID: 21079743)
Mol Med Rep. 2018 Mar;17(3):3667-3673. (PMID: 29257327)
Inflamm Bowel Dis. 2008 Dec;14(12):1615-22. (PMID: 18668679)
Nat Rev Immunol. 2014 Mar;14(3):141-53. (PMID: 24566914)
Comput Struct Biotechnol J. 2022 Apr 04;20:2402-2414. (PMID: 35664229)
Biochim Biophys Acta. 2016 Apr;1858(4):653-60. (PMID: 26724204)
Biochim Biophys Acta Biomembr. 2024 Feb;1866(2):184263. (PMID: 38092232)
Pharmacol Res. 2013 Feb;68(1):1-6. (PMID: 23127916)
Biopharm Drug Dispos. 2003 Nov;24(8):357-65. (PMID: 14595704)
Sci Rep. 2016 Mar 11;6:22887. (PMID: 26965072)
Rheumatology (Oxford). 2020 Apr 1;59(4):869-878. (PMID: 31497857)
Arthritis Rheum. 2003 Nov;48(11):3077-84. (PMID: 14613269)
BMJ Open. 2014 Nov 19;4(11):e006286. (PMID: 25410606)
Biomedicines. 2023 Feb 02;11(2):. (PMID: 36830968)
Eur J Pharmacol. 2019 Apr 5;848:39-48. (PMID: 30689995)
Eur J Cancer. 2018 Apr;93:1-9. (PMID: 29428571)
J Neuroimmune Pharmacol. 2008 Sep;3(3):143-9. (PMID: 18060582)
Gut. 2023 Aug;72(8):1472-1485. (PMID: 36958817)
Front Microbiol. 2022 Oct 18;13:931431. (PMID: 36329847)
Med Sci Monit. 2020 Jan 16;26:e920250. (PMID: 31945029)
Nat Rev Mol Cell Biol. 2020 Jul;21(7):363-383. (PMID: 32231263)
Biomed Rep. 2015 Jul;3(4):491-498. (PMID: 26171154)
Z Rheumatol. 2015 May;74(4):351-8. (PMID: 24972750)
Environ Pollut. 2022 Jun 1;302:119066. (PMID: 35240267)
Hum Mutat. 2012 Jan;33(1):118-23. (PMID: 21922592)
J Orthop Res. 2015 Nov;33(11):1631-8. (PMID: 26010167)
J Inherit Metab Dis. 2004;27(6):778-80. (PMID: 15617188)
Pflugers Arch. 2018 Apr;470(4):669-679. (PMID: 29299689)
Am J Clin Nutr. 2020 Jun 1;111(6):1226-1234. (PMID: 32055828)
Pharm Res. 2018 Oct 2;35(11):224. (PMID: 30280275)
Life Sci. 2006 Jan 18;78(8):803-11. (PMID: 16253281)
Mol Genet Metab Rep. 2018 May 03;15:130-133. (PMID: 30023305)
Molecules. 2019 Dec 19;25(1):. (PMID: 31861504)
Mol Aspects Med. 2011 Aug;32(4-6):223-33. (PMID: 22020112)
Biochem Pharmacol. 2010 Mar 1;79(5):768-76. (PMID: 19819229)
Prev Med. 2012 May;54 Suppl:S71-4. (PMID: 22182480)
PLoS One. 2012;7(10):e47729. (PMID: 23112839)
Eur J Hum Genet. 2006 Feb;14(2):222-6. (PMID: 16333318)
Breast Cancer Res Treat. 2012 Jul;134(1):101-15. (PMID: 22212555)
Osteoarthritis Cartilage. 2023 Aug;31(8):1012-1021. (PMID: 37094761)
Biochem J. 2011 Oct 15;439(2):227-33. (PMID: 21726197)
Sci Rep. 2017 Apr 28;7(1):1258. (PMID: 28455521)
J Neurochem. 2008 Jan;104(1):113-23. (PMID: 17995936)
PLoS One. 2020 Feb 6;15(2):e0228568. (PMID: 32027707)
J Immunol Res. 2015;2015:101879. (PMID: 26613086)
Nat Commun. 2022 Nov 7;13(1):6714. (PMID: 36344565)
Clin Transl Sci. 2021 Jan;14(1):137-142. (PMID: 32905646)
Hum Mutat. 2010 Aug;31(8):E1632-51. (PMID: 20574985)
Pharmacol Rev. 2020 Jan;72(1):253-319. (PMID: 31852803)
J Crohns Colitis. 2021 May 4;15(5):813-826. (PMID: 33175138)
J Rheumatol. 2006 Nov;33(11):2139-45. (PMID: 17086603)
Clin Lab. 2018 Sep 1;64(9):1357-1361. (PMID: 30274012)
Trials. 2022 Feb 22;23(1):170. (PMID: 35193654)
PLoS One. 2015 Nov 04;10(11):e0140569. (PMID: 26536134)
Nat Genet. 2003 Dec;35(4):341-8. (PMID: 14608356)
Eur J Clin Pharmacol. 2019 Aug;75(8):1037-1046. (PMID: 30915521)
Arthritis Res Ther. 2018 Aug 3;20(1):164. (PMID: 30075744)
Drug Metab Pharmacokinet. 2015 Jun;30(3):231-9. (PMID: 26003890)
Mol Pharmacol. 2015 Feb;87(2):314-22. (PMID: 25422143)
Int Immunopharmacol. 2015 Nov;29(1):21-6. (PMID: 25937167)
Mol Genet Metab. 2007 Apr;90(4):441-5. (PMID: 17126586)
SLAS Discov. 2019 Feb;24(2):89-110. (PMID: 30523710)
Aliment Pharmacol Ther. 2011 Nov;34(9):1088-97. (PMID: 21929562)
Gut. 2006 Jun;55(6):809-14. (PMID: 16361305)
Nat Genet. 2004 May;36(5):471-5. (PMID: 15107849)
Front Immunol. 2020 Jan 10;10:2993. (PMID: 31998297)
J Dairy Sci. 2015 Jun;98(6):3840-8. (PMID: 25892691)
FASEB J. 2006 Dec;20(14):2544-6. (PMID: 17065219)
Cancer Res. 2017 Apr 15;77(8):2102-2111. (PMID: 28209616)
Int J Mol Sci. 2020 Dec 01;21(23):. (PMID: 33271927)
J Biol Chem. 2010 Aug 27;285(35):27078-27087. (PMID: 20558736)
Front Immunol. 2023 Mar 31;14:1119564. (PMID: 37063828)
Front Pharmacol. 2019 Nov 19;10:1360. (PMID: 31803054)
Res Vet Sci. 2010 Oct;89(2):200-2. (PMID: 20381822)
Inflamm Bowel Dis. 2011 Aug;17(8):1832-3. (PMID: 21287663)
FEBS Lett. 1997 Dec 8;419(1):107-11. (PMID: 9426230)
Biochim Biophys Acta. 2016 Feb;1858(2):210-9. (PMID: 26607009)
Pharmaceutics. 2019 Aug 07;11(8):. (PMID: 31394757)
Hum Mutat. 2005 Mar;25(3):306-13. (PMID: 15714519)
Toxicol Sci. 2015 Mar;144(1):105-13. (PMID: 25490951)
Biochem Biophys Res Commun. 1999 Aug 2;261(2):484-7. (PMID: 10425211)
Nat Commun. 2022 Jun 21;13(1):3544. (PMID: 35729093)
Hum Mol Genet. 1999 Nov;8(12):2247-54. (PMID: 10545605)
BMC Proc. 2009 Dec 15;3 Suppl 7:S76. (PMID: 20018071)
Curr Opin Pharmacol. 2014 Jun;16:43-9. (PMID: 24681350)
PLoS One. 2022 Mar 11;17(3):e0265189. (PMID: 35275975)
J Leukoc Biol. 2017 Mar;101(3):665-674. (PMID: 27733576)
Hum Mutat. 2000 Jan;15(1):118. (PMID: 10612840)
Dis Colon Rectum. 2008 May;51(5):598-603. (PMID: 18274826)
Curr Opin Toxicol. 2018 Feb;7:133-139. (PMID: 30338308)
Neurochem Res. 2020 Nov;45(11):2664-2678. (PMID: 32844295)
Mol Biosyst. 2015 Dec;11(12):3287-96. (PMID: 26490688)
EXCLI J. 2018 Mar 19;17:257-272. (PMID: 29743863)
Epigenomes. 2020 Aug 03;4(3):. (PMID: 34968289)
J Biol Chem. 2012 Jul 27;287(31):25758-69. (PMID: 22700961)
Scand J Gastroenterol. 2007 Feb;42(2):200-6. (PMID: 17340776)
J Gastroenterol. 2011 Sep;46(9):1081-91. (PMID: 21695374)
Hum Mutat. 2000 Nov;16(5):401-7. (PMID: 11058897)
Inflamm Bowel Dis. 2020 Sep 18;26(10):1524-1532. (PMID: 32766830)
Metab Brain Dis. 2021 Aug;36(6):1391-1401. (PMID: 33710529)
Eur J Pharm Sci. 2017 Aug 30;106:62-70. (PMID: 28549677)
Evid Based Complement Alternat Med. 2022 Jul 1;2022:3319646. (PMID: 35815273)
Clin Nutr ESPEN. 2022 Jun;49:61-67. (PMID: 35623869)
Genet Med. 2010 Jan;12(1):19-24. (PMID: 20027113)
Nutr J. 2014 Aug 04;13:79. (PMID: 25092108)
Clin Exp Immunol. 2009 Apr;156(1):161-71. (PMID: 19175620)
Hum Mutat. 2017 Dec;38(12):1684-1699. (PMID: 28841266)
Front Immunol. 2021 Apr 15;12:660342. (PMID: 33936095)
Clin Chim Acta. 2019 Jan;488:165-171. (PMID: 30419221)
Front Pharmacol. 2020 May 27;11:730. (PMID: 32536865)
Am J Respir Cell Mol Biol. 2007 Jan;36(1):53-60. (PMID: 16917073)
J Crohns Colitis. 2010 Jun;4(2):132-8. (PMID: 21122496)
Nat Genet. 1999 Jan;21(1):91-4. (PMID: 9916797)
Am J Respir Cell Mol Biol. 2005 Jul;33(1):79-88. (PMID: 15817714)
Hum Genet. 1999 Jul-Aug;105(1-2):157-61. (PMID: 10480371)
Int J Rheum Dis. 2018 Jun;21(6):1211-1218. (PMID: 29314768)
Genet Med. 2001 Nov-Dec;3(6):387-92. (PMID: 11715001)
Sci Rep. 2021 Nov 9;11(1):21949. (PMID: 34753981)
Gut. 2008 Oct;57(10):1398-405. (PMID: 18523026)
Inflamm Bowel Dis. 2011 Apr;17(4):907-16. (PMID: 20722056)
J Intern Med. 2020 Feb;287(2):120-133. (PMID: 31710126)
J Biol Chem. 2000 Dec 22;275(51):40064-72. (PMID: 11010964)
World J Gastroenterol. 2007 Feb 28;13(8):1221-9. (PMID: 17451203)
Biochem Biophys Res Commun. 2018 May 5;499(2):182-188. (PMID: 29551687)
J Exp Clin Cancer Res. 2017 Apr 18;36(1):55. (PMID: 28420426)
Nutrients. 2023 Jan 21;15(3):. (PMID: 36771270)
Biochim Biophys Acta. 2012 Mar;1818(3):559-65. (PMID: 22206629)
Reumatologia. 2019;57(1):3-7. (PMID: 30858625)
Am J Physiol Regul Integr Comp Physiol. 2016 Nov 1;311(5):R906-R916. (PMID: 27558316)
Am J Physiol Renal Physiol. 2000 Sep;279(3):F584-91. (PMID: 10966938)
Biochem Biophys Res Commun. 2021 Oct 22;576:27-32. (PMID: 34478916)
Biomed Pharmacother. 2023 Jul;163:114848. (PMID: 37163781)
Biochim Biophys Acta. 2016 Oct;1863(10):2422-35. (PMID: 26828774)
J Biomed Biotechnol. 2004;2004(3):156-166. (PMID: 15292582)
Nutrients. 2022 Aug 15;14(16):. (PMID: 36014845)
J Proteome Res. 2017 Feb 3;16(2):773-779. (PMID: 28092160)
Gene. 2014 Jan 10;533(2):469-76. (PMID: 24148561)
Mol Genet Metab. 2007 Dec;92(4):315-24. (PMID: 17884651)
Hum Genet. 2016 May;135(5):513-524. (PMID: 27023905)
Biochem Pharmacol. 2020 Aug;178:114115. (PMID: 32579962)
Hum Mol Genet. 2008 Oct 1;17(19):2978-85. (PMID: 18614543)
Sci Rep. 2018 Jul 20;8(1):11006. (PMID: 30030472)
Arthritis Res Ther. 2021 Jun 8;23(1):164. (PMID: 34103083)
BMC Genet. 2014 Sep 08;15:90. (PMID: 25299939)
Drug Metab Dispos. 2009 Feb;37(2):330-7. (PMID: 18981167)
Mol Pharmacol. 2006 Nov;70(5):1602-11. (PMID: 16931768)
J Am Heart Assoc. 2016 Feb 22;5(2):. (PMID: 26903003)
Inflamm Bowel Dis. 2012 Mar;18(3):439-48. (PMID: 21793125)
J Pharm Pharmacol. 2016 Sep;68(9):1160-9. (PMID: 27350110)
Mol Genet Metab. 2010 May;100(1):46-50. (PMID: 20074989)
Inflamm Bowel Dis. 2007 Sep;13(9):1083-92. (PMID: 17476680)
Nature. 2003 Jan 23;421(6921):384-8. (PMID: 12508119)
Pediatr Allergy Immunol. 2016 Mar;27(2):185-94. (PMID: 26534891)
Physiol Genomics. 2004 Jun 17;18(1):12-24. (PMID: 15054140)
Drug Metab Dispos. 2007 Mar;35(3):394-401. (PMID: 17142562)
Front Immunol. 2019 Mar 11;10:277. (PMID: 30915065)
Hum Genet. 2014 Aug;133(8):1049-57. (PMID: 24850141)
Pharm Res. 2010 May;27(5):832-40. (PMID: 20224991)
Nat Struct Mol Biol. 2023 Jul;30(7):1001-1011. (PMID: 37291422)
Dig Liver Dis. 2020 Jun;52(6):691-693. (PMID: 32312671)
J Drug Target. 2020 Apr;28(4):437-447. (PMID: 31591905)
Eur J Hum Genet. 2007 Mar;15(3):328-35. (PMID: 17213842)
Neurochem Res. 2018 Jan;43(1):116-128. (PMID: 28688036)
Ann Neurol. 1991 Nov;30(5):709-16. (PMID: 1763895)
J Biochem Mol Toxicol. 2014 May;28(5):206-10. (PMID: 24599653)
BMC Proc. 2007;1 Suppl 1:S13. (PMID: 18466472)
Ann Rheum Dis. 2018 Jul;77(7):1053-1062. (PMID: 29431119)
Int J Colorectal Dis. 2012 Jan;27(1):11-9. (PMID: 21706137)
Pharmaceutics. 2019 Nov 22;11(12):. (PMID: 31766631)
Br J Pharmacol. 2008 Aug;154(8):1558-71. (PMID: 18500366)
J Biomol Screen. 2013 Sep;18(8):851-67. (PMID: 23771822)
Nat Commun. 2019 Nov 5;10(1):5027. (PMID: 31690722)
PLoS Genet. 2017 Mar 6;13(3):e1006641. (PMID: 28263993)
Cell Metab. 2019 Jun 4;29(6):1350-1362.e7. (PMID: 30982734)
Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:663-687. (PMID: 29309257)
Biopharm Drug Dispos. 2013 Jan;34(1):29-44. (PMID: 22952014)
Int J Mol Med. 2019 Oct;44(4):1515-1522. (PMID: 31364739)
Drug Metab Dispos. 2009 Sep;37(9):1871-7. (PMID: 19487253)
Acta Neuropathol. 2023 Oct;146(4):565-583. (PMID: 37548694)
Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5256-61. (PMID: 15795384)
Cells. 2020 Mar 30;9(4):. (PMID: 32235564)
DNA Cell Biol. 2012 Oct;31(10):1549-54. (PMID: 22957492)
PLoS One. 2013 Oct 16;8(10):e76474. (PMID: 24146874)

2022JWT5XS Ministry of Education, Universities and Research; DM 1557 11.10.2022 Ministry of Education, Universities and Research

Keywords: SLC; acetylcholine; antioxidant; carnitine; cation transporters; membrane transporters

0 (Solute Carrier Family 22 Member 5)
0 (SLC22A4 protein, human)
0 (SLC22A5 protein, human)
0 (Organic Cation Transport Proteins)
BDZ3DQM98W (Ergothioneine)
S7UI8SM58A (Carnitine)
N9YNS0M02X (Acetylcholine)
0 (Symporters)

Date Created: 20240427 Date Completed: 20240427 Latest Revision: 20240624

20240625

PMC11048549

10.3390/biom14040392

38672410