Kinetics of Hepatitis E Virus Infections in Asymptomatic Persons.

Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE

Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-

Hepatitis E*/epidemiology ; Hepatitis E*/virology ; Hepatitis E virus*/genetics ; Hepatitis E virus*/immunology ; Viral Load* ; RNA, Viral* ; Blood Donors* ; Viremia*; Humans ; Male ; Adult ; Immunoglobulin M/blood ; Female ; Immunoglobulin G/blood ; Kinetics ; Middle Aged ; Asymptomatic Infections/epidemiology ; Retrospective Studies ; Hepatitis Antibodies/blood ; Germany/epidemiology ; Young Adult

To determine the kinetics of hepatitis E virus (HEV) in asymptomatic persons and to evaluate viral load doubling time and half-life, we retrospectively tested samples retained from 32 HEV RNA-positive asymptomatic blood donors in Germany. Close-meshed monitoring of viral load and seroconversion in intervals of ≈4 days provided more information about the kinetics of asymptomatic HEV infections. We determined that a typical median infection began with PCR-detectable viremia at 36 days and a maximum viral load of 2.0 × 10 ⁴ IU/mL. Viremia doubled in 2.4 days and had a half-life of 1.6 days. HEV IgM started to rise on about day 33 and peaked on day 36; IgG started to rise on about day 32 and peaked on day 53. Although HEV IgG titers remained stable, IgM titers became undetectable in 40% of donors. Knowledge of the dynamics of HEV viremia is useful for assessing the risk for transfusion-transmitted hepatitis E.

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Keywords: Germany; Hepatitis E virus; asymptomatic; blood safety; doubling time; hepatitis; immune response; transfusion; viruses

0 (RNA, Viral)
0 (Immunoglobulin M)
0 (Immunoglobulin G)
0 (Hepatitis Antibodies)

Date Created: 20240426 Date Completed: 20240426 Latest Revision: 20240502

20250114

PMC11060471

10.3201/eid3005.231764

38666600