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Correlation between sentinel lymph node biopsy and non-sentinel lymph node metastasis in patients with cN0 breast carcinoma: comparison of invasive ductal carcinoma and invasive lobular carcinoma.

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  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101170544 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-7819 (Electronic) Linking ISSN: 14777819 NLM ISO Abbreviation: World J Surg Oncol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : BioMed Central, 2003-
    • الموضوع:
      Carcinoma, Lobular*/pathology ; Carcinoma, Ductal, Breast*/pathology ; Breast Neoplasms*/surgery ; Breast Neoplasms*/pathology ; Sentinel Lymph Node*/surgery ; Sentinel Lymph Node*/pathology; Humans ; Female ; Sentinel Lymph Node Biopsy ; Lymphatic Metastasis/pathology ; Retrospective Studies ; Lymph Node Excision ; Lymph Nodes/pathology ; Axilla/pathology
    • نبذة مختصرة :
      Background: Some studies have suggested that axillary lymph node dissection (ALND) can be avoided in women with cN0 breast cancer with 1-2 positive sentinel nodes (SLNs). However, these studies included only a few patients with invasive lobular carcinoma (ILC), so the validity of omitting ALDN in these patients remains controversial. This study compared the frequency of non-sentinel lymph nodes (non-SLNs) metastases in ILC and invasive ductal carcinoma (IDC).
      Materials Methods: Data relating to a total of 2583 patients with infiltrating breast carcinoma operated at our institution between 2012 and 2023 were retrospectively analyzed: 2242 (86.8%) with IDC and 341 (13.2%) with ILC. We compared the incidence of metastasis to SLNs and non-SLNs between the ILC and IDC cohorts and examined factors that influenced non-SLNs metastasis.
      Results: SLN biopsies were performed in 315 patients with ILC and 2018 patients with IDC. Metastases to the SLNs were found in 78/315 (24.8%) patients with ILC and in 460 (22.8%) patients with IDC (p = 0.31). The incidence of metastases to non-SLNs was significantly higher (p = 0.02) in ILC (52/78-66.7%) compared to IDC (207/460 - 45%). Multivariate analysis showed that ILC was the most influential predictive factor in predicting the presence of metastasis to non-SLNs.
      Conclusions: ILC cases have more non-SLNs metastases than IDC cases in SLN-positive patients. The ILC is essential for predicting non-SLN positivity in macro-metastases in the SLN. The option of omitting ALND in patients with ILC with 1-2 positive SLNs still requires further investigation.
      (© 2024. The Author(s).)
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    • Contributed Indexing:
      Keywords: Axillary lymphadenectomy; Breast carcinoma; Infiltrating ductal carcinoma; Infiltrating lobular carcinoma; Non-sentinel lymph node metastasis; Sentinel lymph node biopsy
    • الموضوع:
      Date Created: 20240416 Date Completed: 20240418 Latest Revision: 20240425
    • الموضوع:
      20240425
    • الرقم المعرف:
      PMC11022323
    • الرقم المعرف:
      10.1186/s12957-024-03375-9
    • الرقم المعرف:
      38627759