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Diagnostic performance of PIVKA-II in identifying recurrent hepatocellular carcinoma following curative resection: a retrospective cohort study.

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  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Carcinoma, Hepatocellular*/diagnosis ; Carcinoma, Hepatocellular*/surgery ; Liver Neoplasms*/diagnosis ; Liver Neoplasms*/surgery ; Liver Neoplasms*/pathology ; Protein Precursors*; Humans ; Retrospective Studies ; alpha-Fetoproteins/metabolism ; Biomarkers ; Prothrombin ; Biomarkers, Tumor
    • نبذة مختصرة :
      Protein induced by vitamin K absence or antagonist II (PIVKA-II) plays a critical role in the diagnosis of hepatocellular carcinoma (HCC), however, studies on its efficacy in diagnosing recurrent HCC were rarely found. A multicenter, retrospective, and observational study was conducted. During the overall follow-up of 5 years, HCC patients who had curative resection were monitored every 3 months in the first year post-surgery and every 6 months thereafter if no recurrence occurred. Tumor markers were collected at the diagnosis of recurrence for those with recurrence and at the last follow-up for those without recurrence. The median serum levels of PIVKA-II and AFP in the recurrence group were significantly higher than those in the non-recurrence group (PIVKA-II: 84.62 vs. 18.76 mAU/ml, p < 0.001; AFP: 4.90 vs. 3.00 ng/ml, p < 0.001) and there is a significant correlation between PIVKA-II and AFP (R = 0.901, p < 0.001). PIVKA-II showed better accuracy than AFP in the diagnosis of overall recurrent HCC (AUC: 0.883 vs. 0.672; p < 0.0001), but also in patients with negative PIVKA-II before curative resection (AUC: 0.878 vs. 0.680, p = 0.001). Clinician should pay more attention to serum PIVKA-II values when following patients after curative HCC resection to detect early recurrence.Clinical trial registration: ChiCTR2300070874.
      (© 2024. The Author(s).)
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    • Grant Information:
      82100691 National Natural Science Foundation of China; 82270688 National Natural Science Foundation of China; 82070673 National Natural Science Foundation of China
    • الرقم المعرف:
      53230-14-1 (acarboxyprothrombin)
      0 (alpha-Fetoproteins)
      0 (Biomarkers)
      9001-26-7 (Prothrombin)
      0 (Biomarkers, Tumor)
      0 (Protein Precursors)
    • الموضوع:
      Date Created: 20240410 Date Completed: 20240412 Latest Revision: 20240429
    • الموضوع:
      20240430
    • الرقم المعرف:
      PMC11006886
    • الرقم المعرف:
      10.1038/s41598-024-59174-5
    • الرقم المعرف:
      38600210