Post-translational modifications: emerging directors of cell-fate decisions during endoplasmic reticulum stress in Arabidopsis thaliana.

Publisher: Portland Press On The Behalf Of The Biochemical Society Country of Publication: England NLM ID: 7506897 Publication Model: Print Cited Medium: Internet ISSN: 1470-8752 (Electronic) Linking ISSN: 03005127 NLM ISO Abbreviation: Biochem Soc Trans Subsets: MEDLINE

Original Publication: London : Portland Press On The Behalf Of The Biochemical Society

Arabidopsis*/metabolism ; Endoplasmic Reticulum Stress* ; Protein Processing, Post-Translational*; Arabidopsis Proteins/metabolism ; Endoplasmic Reticulum/metabolism

Homeostasis of the endoplasmic reticulum (ER) is critical for growth, development, and stress responses. Perturbations causing an imbalance in ER proteostasis lead to a potentially lethal condition known as ER stress. In ER stress situations, cell-fate decisions either activate pro-life pathways that reestablish homeostasis or initiate pro-death pathways to prevent further damage to the organism. Understanding the mechanisms underpinning cell-fate decisions in ER stress is critical for crop development and has the potential to enable translation of conserved components to ER stress-related diseases in metazoans. Post-translational modifications (PTMs) of proteins are emerging as key players in cell-fate decisions in situations of imbalanced ER proteostasis. In this review, we address PTMs orchestrating cell-fate decisions in ER stress in plants and provide evidence-based perspectives for where future studies may focus to identify additional PTMs involved in ER stress management.
(© 2024 The Author(s).)

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R35 GM136637 United States GM NIGMS NIH HHS

Keywords: Arabidopsis thaliana; ER stress; UPR; cell-fate; post translational modification; programmed cell death

0 (Arabidopsis Proteins)

Date Created: 20240410 Date Completed: 20240424 Latest Revision: 20250104

20250114

PMC11088923

10.1042/BST20231025

38600022