Remediation of Metal Oxide Nanotoxicity with a Functional Amyloid.

Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

Original Publication: Weinheim : WILEY-VCH, [2014]-

Amyloid*/metabolism ; Amyloid*/chemistry ; Amyloid*/toxicity ; Copper*/toxicity ; Copper*/chemistry; Animals ; Mice ; Metal Nanoparticles/toxicity ; Metal Nanoparticles/chemistry ; Zinc Oxide/toxicity ; Zinc Oxide/chemistry ; Lactoglobulins/chemistry ; Cell Survival/drug effects ; Molecular Dynamics Simulation ; Humans ; Oxides/toxicity ; Oxides/chemistry

Understanding the environmental health and safety of nanomaterials (NanoEHS) is essential for the sustained development of nanotechnology. Although extensive research over the past two decades has elucidated the phenomena, mechanisms, and implications of nanomaterials in cellular and organismal models, the active remediation of the adverse biological and environmental effects of nanomaterials remains largely unexplored. Inspired by recent developments in functional amyloids for biomedical and environmental engineering, this work shows their new utility as metallothionein mimics in the strategically important area of NanoEHS. Specifically, metal ions released from CuO and ZnO nanoparticles are sequestered through cysteine coordination and electrostatic interactions with beta-lactoglobulin (bLg) amyloid, as revealed by inductively coupled plasma mass spectrometry and molecular dynamics simulations. The toxicity of the metal oxide nanoparticles is subsequently mitigated by functional amyloids, as validated by cell viability and apoptosis assays in vitro and murine survival and biomarker assays in vivo. As bLg amyloid fibrils can be readily produced from whey in large quantities at a low cost, the study offers a crucial strategy for remediating the biological and environmental footprints of transition metal oxide nanomaterials.
(© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.)

ACS Appl Mater Interfaces. 2023 Feb 15;15(6):7777-7792. (PMID: 36724494)
Small. 2013 Apr 8;9(7):970-82. (PMID: 23296910)
Environ Int. 2022 Jan;158:106923. (PMID: 34634619)
Adv Sci (Weinh). 2024 Jun;11(23):e2310314. (PMID: 38582521)
Environ Pollut. 2012 Oct;169:81-9. (PMID: 22694973)
Nanoscale. 2014;6(3):1707-15. (PMID: 24343273)
Toxicol In Vitro. 2010 Apr;24(3):872-8. (PMID: 19969064)
J Dairy Sci. 2004 Apr;87(4):785-96. (PMID: 15259212)
Small. 2020 May;16(21):e2000963. (PMID: 32338442)
J Hazard Mater. 2021 Jan 5;401:123349. (PMID: 32659578)
ACS Nano. 2011 Sep 27;5(9):7284-95. (PMID: 21851096)
RSC Adv. 2018 Feb 13;8(13):6915-6924. (PMID: 35540346)
Nat Nanotechnol. 2010 Jun;5(6):423-8. (PMID: 20383125)
Part Fibre Toxicol. 2005 Oct 06;2:8. (PMID: 16209704)
Curr Top Med Chem. 2015;15(18):1914-29. (PMID: 25961521)
Chem Soc Rev. 2020 Aug 7;49(15):5473-5509. (PMID: 32632432)
Nat Commun. 2023 Apr 3;14(1):1848. (PMID: 37012278)
Comp Biochem Physiol C Toxicol Pharmacol. 2008 Apr;147(3):316-23. (PMID: 18178529)
J Appl Toxicol. 2021 May;41(5):683-700. (PMID: 33244813)
J Mol Model. 2016 Sep;22(9):206. (PMID: 27502172)
J Colloid Interface Sci. 2018 Oct 1;527:117-123. (PMID: 29787947)
Environ Sci Nano. 2017 Jul 1;7(4):1433-1454. (PMID: 29123668)
Biomacromolecules. 2011 Jan 10;12(1):187-93. (PMID: 21142059)
Small. 2020 May;16(21):e2000603. (PMID: 32338451)
J Hazard Mater. 2024 Mar 5;465:133050. (PMID: 38000282)
Chem Soc Rev. 2017 Oct 30;46(21):6492-6531. (PMID: 28702523)
Front Neurosci. 2022 Jun 02;16:878869. (PMID: 35720732)
J Am Chem Soc. 2007 Sep 5;129(35):10911-21. (PMID: 17696343)
J Am Chem Soc. 2015 Jan 14;137(1):22-5. (PMID: 25415595)
J Environ Pathol Toxicol Oncol. 2018;37(3):209-230. (PMID: 30317972)
Environ Sci Technol. 2007 Dec 15;41(24):8484-90. (PMID: 18200883)
Adv Mater. 2022 Mar;34(11):e2106456. (PMID: 35029313)
Science. 2006 Feb 3;311(5761):622-7. (PMID: 16456071)
Nanomaterials (Basel). 2022 Nov 30;12(23):. (PMID: 36500887)
Nanoscale. 2014 Jun 21;6(12):7052-61. (PMID: 24842463)
Biomacromolecules. 2017 Dec 11;18(12):4316-4322. (PMID: 29095600)
J Agric Food Chem. 2013 Aug 14;61(32):7817-28. (PMID: 23848407)
Sci Rep. 2023 Jan 31;13(1):985. (PMID: 36720893)
Nat Nanotechnol. 2017 Jul;12(7):642-647. (PMID: 28436960)
Biomaterials. 2008 Apr;29(11):1553-62. (PMID: 18164758)
Nat Nanotechnol. 2016 Apr;11(4):365-71. (PMID: 26809058)
Metallomics. 2011 Jan;3(1):61-73. (PMID: 21553704)
Int J Biol Macromol. 2023 Jul 1;242(Pt 2):124855. (PMID: 37187417)
Chemosphere. 2008 Apr;71(7):1308-16. (PMID: 18194809)
Structure. 2008 Jul;16(7):1010-8. (PMID: 18611374)
Part Fibre Toxicol. 2006 Aug 14;3:11. (PMID: 16907977)
Nat Commun. 2018 Dec 21;9(1):5443. (PMID: 30575744)
J Biol Inorg Chem. 2011 Oct;16(7):991-1009. (PMID: 21823038)
Res Rep Health Eff Inst. 2009 Jan;(136):3-32. (PMID: 19552347)
Nat Commun. 2021 May 31;12(1):3248. (PMID: 34059677)
Nat Nanotechnol. 2021 Aug;16(8):926-932. (PMID: 33986512)
Beilstein J Nanotechnol. 2014 Sep 24;5:1625-36. (PMID: 25383275)
J Vasc Res. 2014;51(3):231-8. (PMID: 25116857)
Nat Rev Mol Cell Biol. 2018 Dec;19(12):755-773. (PMID: 30237470)
Environ Sci Technol. 2018 Jul 17;52(14):7996-8004. (PMID: 29944347)
Biomacromolecules. 2008 May;9(5):1474-9. (PMID: 18416530)
Int J Nanomedicine. 2020 May 28;15:3827-3842. (PMID: 32581533)
Environ Sci Technol. 2021 Dec 21;55(24):16270-16282. (PMID: 34854667)
Biochim Biophys Acta. 2013 Oct;1828(10):2328-38. (PMID: 23746423)
Nanomaterials (Basel). 2021 Apr 04;11(4):. (PMID: 33916509)
ACS Nano. 2020 Apr 28;14(4):4166-4177. (PMID: 32191835)
Langmuir. 2019 Mar 19;35(11):4161-4170. (PMID: 30811203)
Nat Nanotechnol. 2021 Aug;16(8):918-925. (PMID: 34083772)
Chem Commun (Camb). 2017 Aug 22;53(68):9394-9397. (PMID: 28745731)
Biomacromolecules. 2008 Sep;9(9):2477-86. (PMID: 18698816)
Angew Chem Int Ed Engl. 2024 Feb 26;63(9):e202309958. (PMID: 37943171)
PLoS One. 2016 Feb 18;11(2):e0149484. (PMID: 26890000)
Environ Sci Technol. 2023 Aug 22;57(33):12376-12387. (PMID: 37561908)
Cold Spring Harb Perspect Biol. 2019 Dec 2;11(12):. (PMID: 31088827)
Nat Commun. 2023 Oct 26;14(1):6806. (PMID: 37884488)
Science. 2022 Mar 18;375(6586):1254-1261. (PMID: 35298263)
Environ Sci Technol. 2011 Aug 1;45(15):6617-24. (PMID: 21710986)
Int J Mol Sci. 2014 Jul 14;15(7):12379-406. (PMID: 25026171)
Small. 2013 May 27;9(9-10):1776-85. (PMID: 23180726)
Arch Toxicol. 2013 Jul;87(7):1181-200. (PMID: 23728526)
J Agric Food Chem. 2012 Sep 19;60(37):9476-83. (PMID: 22924475)
Small. 2020 May;16(21):e2000528. (PMID: 32337854)
Int J Antimicrob Agents. 2009 Jun;33(6):587-90. (PMID: 19195845)
Science. 2022 Mar 18;375(6586):1231-1232. (PMID: 35298241)
Environ Sci Technol. 2012 Nov 6;46(21):12178-85. (PMID: 23046143)
Environ Sci Technol. 2011 Mar 1;45(5):1977-83. (PMID: 21280647)
Environ Sci Technol. 2018 Sep 18;52(18):10590-10598. (PMID: 30125093)

T2250710182 National Natural Science Foundation of China; 22306145 National Natural Science Foundation of China; PRG2188 Eesti Teadusagentuur; Fundamental Research Funds for the Central Universities; 2022YFC2409700 Key Technologies Research and Development Program; 2021YFA12009000 Key Technologies Research and Development Program

Keywords: functional amyloid; ion release; metal oxide nanoparticle; sequestration; toxicity

0 (Amyloid)
789U1901C5 (Copper)
SOI2LOH54Z (Zinc Oxide)
0 (Lactoglobulins)
V1XJQ704R4 (cupric oxide)
0 (Oxides)

Date Created: 20240406 Date Completed: 20240619 Latest Revision: 20240622

20240622

PMC11187920

10.1002/advs.202310314

38582521