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Bilateral juvenile osteochondrosis dissecans in monozygotic twins: a case report.

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  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101265112 Publication Model: Electronic Cited Medium: Internet ISSN: 1749-799X (Electronic) Linking ISSN: 1749799X NLM ISO Abbreviation: J Orthop Surg Res Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : BioMed Central, 2006-
    • الموضوع:
      Osteochondritis Dissecans*/diagnostic imaging ; Osteochondritis Dissecans*/genetics ; Osteochondrosis*/diagnostic imaging ; Osteochondrosis*/genetics; Humans ; Knee Joint/pathology ; Magnetic Resonance Imaging ; Radiography ; Twins, Monozygotic
    • نبذة مختصرة :
      Introduction: The etiology of osteochondrosis dissecans (OCD), a chondropathy associated with detachment of the subchondral bone and the overlaying cartilage, is not yet fully understood. While repetitive physical exercise-related stress is usually assumed to be the main risk factor for the occurrence of OCD, genetic predisposition could have an underestimated influence on the development of the disease.
      Case Report: We report a case of monozygotic twins with almost identical stages of bilateral osteochondrosis dissecans of the knee joint. In both patients, initially, a unilateral lesion occurred; despite restricted physical exercise, in the further course of the disease a lesion also developed on the contralateral side. While the lesion found most recently demonstrated an ongoing healing process at a 6-month follow-up, the other three lesions showed a natural course of healing under conservative treatment with significant clinical as well as radiological improvements after one year and complete consolidation in magnetic resonance imaging (MRI) after 2 years.
      Conclusion: There could be a genetic component to the development of OCD, although this has not yet been proven. Based on a two-year MRI follow-up, we were able to show the self-limiting characteristics of juvenile osteochondrosis dissecans.
      (© 2024. The Author(s).)
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    • Contributed Indexing:
      Keywords: AOCD; Femoral condyle; JOCD; Osteochondral lesion; Osteochondrosis dissecans
    • الموضوع:
      Date Created: 20240402 Date Completed: 20240403 Latest Revision: 20240724
    • الموضوع:
      20240725
    • الرقم المعرف:
      PMC10983665
    • الرقم المعرف:
      10.1186/s13018-024-04683-2
    • الرقم المعرف:
      38561825